Combination of different probiotics and berry-derived (poly)phenols can modulate immune response in dendritic cells
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Combination of different probiotics and berry-derived (poly)phenols can modulate immune response in dendritic cells. / Taverniti, Valentina; Del Bo', Cristian; Fiore, Walter; Gargari, Giorgio; Arioli, Stefania; Riso, Patrizia; Guglielmetti, Simone; Frøkiær, Hanne.
I: Journal of Functional Foods, Bind 94, 105121, 2022.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Combination of different probiotics and berry-derived (poly)phenols can modulate immune response in dendritic cells
AU - Taverniti, Valentina
AU - Del Bo', Cristian
AU - Fiore, Walter
AU - Gargari, Giorgio
AU - Arioli, Stefania
AU - Riso, Patrizia
AU - Guglielmetti, Simone
AU - Frøkiær, Hanne
N1 - Publisher Copyright: © 2022
PY - 2022
Y1 - 2022
N2 - The immunomodulatory potential of probiotics and (poly)phenols (PP) is recognized; however, studies regarding microorganisms-PP synergisms are yet to be explored. Here, we investigated the cooperation between probiotics and berry-derived PP extracts in modulating the cytokine responses in dendritic cells. Bacteria elicited immune responses in a strain-dependent manner. PP extracts showed different modulation of cytokine triggered by bacteria. Also with LPS, used as pro-inflammatory stimulus, PP from blueberry (BB) and cranberry (CB) most efficiently reduced IL12 production. L. paracasei LPC-S01 and B. bifidum MIMBb23sg resulted the best bacterial association in abrogating IL12 and increasing IL10. The use of PP fraction from BB50f and CB1 with the LPC-S01 + MIMBb23sg association resulted the most efficient combinations in terms of anti-inflammatory activity. These results provide bases for further investigation in vivo, in the perspective to develop food supplements that might conceivably deliver the single and combined benefits of probiotics and berry (poly)phenols.
AB - The immunomodulatory potential of probiotics and (poly)phenols (PP) is recognized; however, studies regarding microorganisms-PP synergisms are yet to be explored. Here, we investigated the cooperation between probiotics and berry-derived PP extracts in modulating the cytokine responses in dendritic cells. Bacteria elicited immune responses in a strain-dependent manner. PP extracts showed different modulation of cytokine triggered by bacteria. Also with LPS, used as pro-inflammatory stimulus, PP from blueberry (BB) and cranberry (CB) most efficiently reduced IL12 production. L. paracasei LPC-S01 and B. bifidum MIMBb23sg resulted the best bacterial association in abrogating IL12 and increasing IL10. The use of PP fraction from BB50f and CB1 with the LPC-S01 + MIMBb23sg association resulted the most efficient combinations in terms of anti-inflammatory activity. These results provide bases for further investigation in vivo, in the perspective to develop food supplements that might conceivably deliver the single and combined benefits of probiotics and berry (poly)phenols.
KW - B. bifidum
KW - Blueberry
KW - Cranberry
KW - IL-10
KW - L. paracasei
KW - Synergism
U2 - 10.1016/j.jff.2022.105121
DO - 10.1016/j.jff.2022.105121
M3 - Journal article
AN - SCOPUS:85131070497
VL - 94
JO - Journal of Functional Foods
JF - Journal of Functional Foods
SN - 1756-4646
M1 - 105121
ER -
ID: 313495470