Comparison of virulence of different Actinobacillus pleuropneumoniae serotypes and biotypes using an aerosol infection model

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Comparison of virulence of different Actinobacillus pleuropneumoniae serotypes and biotypes using an aerosol infection model. / Jacobsen, Mariann Juul; Nielsen, Jens Peter; Nielsen, Ragnhild.

I: Veterinary Microbiology, Bind 49, Nr. 3-4, 04.1996, s. 159-168.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Jacobsen, MJ, Nielsen, JP & Nielsen, R 1996, 'Comparison of virulence of different Actinobacillus pleuropneumoniae serotypes and biotypes using an aerosol infection model', Veterinary Microbiology, bind 49, nr. 3-4, s. 159-168. https://doi.org/10.1016/0378-1135(95)00184-0

APA

Jacobsen, M. J., Nielsen, J. P., & Nielsen, R. (1996). Comparison of virulence of different Actinobacillus pleuropneumoniae serotypes and biotypes using an aerosol infection model. Veterinary Microbiology, 49(3-4), 159-168. https://doi.org/10.1016/0378-1135(95)00184-0

Vancouver

Jacobsen MJ, Nielsen JP, Nielsen R. Comparison of virulence of different Actinobacillus pleuropneumoniae serotypes and biotypes using an aerosol infection model. Veterinary Microbiology. 1996 apr.;49(3-4):159-168. https://doi.org/10.1016/0378-1135(95)00184-0

Author

Jacobsen, Mariann Juul ; Nielsen, Jens Peter ; Nielsen, Ragnhild. / Comparison of virulence of different Actinobacillus pleuropneumoniae serotypes and biotypes using an aerosol infection model. I: Veterinary Microbiology. 1996 ; Bind 49, Nr. 3-4. s. 159-168.

Bibtex

@article{10c0cf0765e145729493f850bdd6162e,
title = "Comparison of virulence of different Actinobacillus pleuropneumoniae serotypes and biotypes using an aerosol infection model",
abstract = "An aerosol infection model for inoculation of pigs with Actinobacillus pleuropneumoniae is described. With this model the virulence of three A. pleuropneumoniae biotype 1 strains representing serotypes 2, 5b and 6, and one Danish biotype 2 were compared using 13-week-old pigs for inoculation. The pigs were sacrificed 24 h after aerosol exposure and lung lesions were evaluated. In pigs exposed to aerosols of suspensions containing 104 CFU/ml of serotypes 2, 5b and 6, a number of 5-10 lesions of haemorrhagic necrotizing pneumonia were induced. For the biotype 2 strain the dose creating similar lesions was 109 CFU/ml. Repeatad experiments confirmed these results showing similar virulence of serotypes 2, 5b and 6 whereas the biotype 2 strain proved less virulent. The aerosol infection model allowed a comparison of the number of A. pleuropneumoniae CFU/liter air which were necessary to induce lung lesions in susceptible pigs. This indicates that the model will be well suited for virulence studies of A. pleuropneumoniae serotypes in pigs.",
keywords = "Actinobacillus pleuropneumoniae, aerosol infection model, biotype 1 and 2, virulence",
author = "Jacobsen, {Mariann Juul} and Nielsen, {Jens Peter} and Ragnhild Nielsen",
year = "1996",
month = apr,
doi = "10.1016/0378-1135(95)00184-0",
language = "English",
volume = "49",
pages = "159--168",
journal = "Veterinary Microbiology",
issn = "0378-1135",
publisher = "Elsevier",
number = "3-4",

}

RIS

TY - JOUR

T1 - Comparison of virulence of different Actinobacillus pleuropneumoniae serotypes and biotypes using an aerosol infection model

AU - Jacobsen, Mariann Juul

AU - Nielsen, Jens Peter

AU - Nielsen, Ragnhild

PY - 1996/4

Y1 - 1996/4

N2 - An aerosol infection model for inoculation of pigs with Actinobacillus pleuropneumoniae is described. With this model the virulence of three A. pleuropneumoniae biotype 1 strains representing serotypes 2, 5b and 6, and one Danish biotype 2 were compared using 13-week-old pigs for inoculation. The pigs were sacrificed 24 h after aerosol exposure and lung lesions were evaluated. In pigs exposed to aerosols of suspensions containing 104 CFU/ml of serotypes 2, 5b and 6, a number of 5-10 lesions of haemorrhagic necrotizing pneumonia were induced. For the biotype 2 strain the dose creating similar lesions was 109 CFU/ml. Repeatad experiments confirmed these results showing similar virulence of serotypes 2, 5b and 6 whereas the biotype 2 strain proved less virulent. The aerosol infection model allowed a comparison of the number of A. pleuropneumoniae CFU/liter air which were necessary to induce lung lesions in susceptible pigs. This indicates that the model will be well suited for virulence studies of A. pleuropneumoniae serotypes in pigs.

AB - An aerosol infection model for inoculation of pigs with Actinobacillus pleuropneumoniae is described. With this model the virulence of three A. pleuropneumoniae biotype 1 strains representing serotypes 2, 5b and 6, and one Danish biotype 2 were compared using 13-week-old pigs for inoculation. The pigs were sacrificed 24 h after aerosol exposure and lung lesions were evaluated. In pigs exposed to aerosols of suspensions containing 104 CFU/ml of serotypes 2, 5b and 6, a number of 5-10 lesions of haemorrhagic necrotizing pneumonia were induced. For the biotype 2 strain the dose creating similar lesions was 109 CFU/ml. Repeatad experiments confirmed these results showing similar virulence of serotypes 2, 5b and 6 whereas the biotype 2 strain proved less virulent. The aerosol infection model allowed a comparison of the number of A. pleuropneumoniae CFU/liter air which were necessary to induce lung lesions in susceptible pigs. This indicates that the model will be well suited for virulence studies of A. pleuropneumoniae serotypes in pigs.

KW - Actinobacillus pleuropneumoniae

KW - aerosol infection model

KW - biotype 1 and 2

KW - virulence

UR - http://www.scopus.com/inward/record.url?scp=0030014141&partnerID=8YFLogxK

U2 - 10.1016/0378-1135(95)00184-0

DO - 10.1016/0378-1135(95)00184-0

M3 - Journal article

C2 - 8734634

AN - SCOPUS:0030014141

VL - 49

SP - 159

EP - 168

JO - Veterinary Microbiology

JF - Veterinary Microbiology

SN - 0378-1135

IS - 3-4

ER -

ID: 285716159