Considering the microbiota to achieve reduction in the numbers of animals used in scientific studies

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Standard

Considering the microbiota to achieve reduction in the numbers of animals used in scientific studies. / Hansen, Axel Kornerup.

I: Istituto Superiore di Sanita. Annali, Bind 55, Nr. 4, 2019, s. 405-407.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Hansen, AK 2019, 'Considering the microbiota to achieve reduction in the numbers of animals used in scientific studies', Istituto Superiore di Sanita. Annali, bind 55, nr. 4, s. 405-407. https://doi.org/10.4415/ANN_19_04_17

APA

Hansen, A. K. (2019). Considering the microbiota to achieve reduction in the numbers of animals used in scientific studies. Istituto Superiore di Sanita. Annali, 55(4), 405-407. https://doi.org/10.4415/ANN_19_04_17

Vancouver

Hansen AK. Considering the microbiota to achieve reduction in the numbers of animals used in scientific studies. Istituto Superiore di Sanita. Annali. 2019;55(4):405-407. https://doi.org/10.4415/ANN_19_04_17

Author

Hansen, Axel Kornerup. / Considering the microbiota to achieve reduction in the numbers of animals used in scientific studies. I: Istituto Superiore di Sanita. Annali. 2019 ; Bind 55, Nr. 4. s. 405-407.

Bibtex

@article{29cbfbe7e4b644b2a84a5a57295cc7ab,
title = "Considering the microbiota to achieve reduction in the numbers of animals used in scientific studies",
abstract = "Elimination of pathogens by laboratory rodent commercial vendors has substantially improved standardized conditions as well as laboratory animal welfare. However, pathogens are also important for basic activation and functioning of the immune system with consequential influences on the symbiotic bacteria composition in the individual microbiota. One of the reasons for failures of translating results from preclinical research to the clinical phase in some studies could be due to unintentional selection processes. Some recommendations are provided to increase researchers' awareness on this point, together with a practical checklist to optimize information from microbiota knowledge.",
author = "Hansen, {Axel Kornerup}",
year = "2019",
doi = "10.4415/ANN_19_04_17",
language = "English",
volume = "55",
pages = "405--407",
journal = "Istituto Superiore di Sanita. Annali",
issn = "0021-2571",
publisher = "IlPensiero Scientifico Editore",
number = "4",

}

RIS

TY - JOUR

T1 - Considering the microbiota to achieve reduction in the numbers of animals used in scientific studies

AU - Hansen, Axel Kornerup

PY - 2019

Y1 - 2019

N2 - Elimination of pathogens by laboratory rodent commercial vendors has substantially improved standardized conditions as well as laboratory animal welfare. However, pathogens are also important for basic activation and functioning of the immune system with consequential influences on the symbiotic bacteria composition in the individual microbiota. One of the reasons for failures of translating results from preclinical research to the clinical phase in some studies could be due to unintentional selection processes. Some recommendations are provided to increase researchers' awareness on this point, together with a practical checklist to optimize information from microbiota knowledge.

AB - Elimination of pathogens by laboratory rodent commercial vendors has substantially improved standardized conditions as well as laboratory animal welfare. However, pathogens are also important for basic activation and functioning of the immune system with consequential influences on the symbiotic bacteria composition in the individual microbiota. One of the reasons for failures of translating results from preclinical research to the clinical phase in some studies could be due to unintentional selection processes. Some recommendations are provided to increase researchers' awareness on this point, together with a practical checklist to optimize information from microbiota knowledge.

U2 - 10.4415/ANN_19_04_17

DO - 10.4415/ANN_19_04_17

M3 - Journal article

C2 - 31850871

VL - 55

SP - 405

EP - 407

JO - Istituto Superiore di Sanita. Annali

JF - Istituto Superiore di Sanita. Annali

SN - 0021-2571

IS - 4

ER -

ID: 234221234