Dereplication-guided isolation of depsides thielavins S-T and lecanorins D-F from the endophytic fungus Setophoma sp.

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Standard

Dereplication-guided isolation of depsides thielavins S-T and lecanorins D-F from the endophytic fungus Setophoma sp. / de Medeiros, Lívia S.; Abreu, Lucas M.; Nielsen, Anita; Ingmer, Hanne; Larsen, Thomas O.; Nielsen, Kristian F.; Rodrigues-Filho, Edson.

I: Phytochemistry, Bind 111, 2015, s. 154-162.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

de Medeiros, LS, Abreu, LM, Nielsen, A, Ingmer, H, Larsen, TO, Nielsen, KF & Rodrigues-Filho, E 2015, 'Dereplication-guided isolation of depsides thielavins S-T and lecanorins D-F from the endophytic fungus Setophoma sp.', Phytochemistry, bind 111, s. 154-162. https://doi.org/10.1016/j.phytochem.2014.12.020

APA

de Medeiros, L. S., Abreu, L. M., Nielsen, A., Ingmer, H., Larsen, T. O., Nielsen, K. F., & Rodrigues-Filho, E. (2015). Dereplication-guided isolation of depsides thielavins S-T and lecanorins D-F from the endophytic fungus Setophoma sp. Phytochemistry, 111, 154-162. https://doi.org/10.1016/j.phytochem.2014.12.020

Vancouver

de Medeiros LS, Abreu LM, Nielsen A, Ingmer H, Larsen TO, Nielsen KF o.a. Dereplication-guided isolation of depsides thielavins S-T and lecanorins D-F from the endophytic fungus Setophoma sp. Phytochemistry. 2015;111:154-162. https://doi.org/10.1016/j.phytochem.2014.12.020

Author

de Medeiros, Lívia S. ; Abreu, Lucas M. ; Nielsen, Anita ; Ingmer, Hanne ; Larsen, Thomas O. ; Nielsen, Kristian F. ; Rodrigues-Filho, Edson. / Dereplication-guided isolation of depsides thielavins S-T and lecanorins D-F from the endophytic fungus Setophoma sp. I: Phytochemistry. 2015 ; Bind 111. s. 154-162.

Bibtex

@article{cab6dc8549f641f5a9b4974b5b3530a5,
title = "Dereplication-guided isolation of depsides thielavins S-T and lecanorins D-F from the endophytic fungus Setophoma sp.",
abstract = "Dereplication methodology using UHPLC-DAD-QTOFMS was applied during the metabolic profiling investigation of the endophyte Setophoma sp., a fungus isolated from symptomless guava fruits. The approach performed allowed a fast analysis of the microbial secondary metabolites. From this fungus, seven highly C-alkylated depsides were isolated and identified as polyketides thielavins S, T, U and V and lecanorins D, E and F. Their structures were elucidated through spectroscopic methods including NMR, HRMS and especially with assistance of HRMS/MS experiments. The compounds were tested for quorum sensing regulation activity in the virulence gene expression of Staphylococcus aureus, but no inhibitory effect was detected. Nevertheless, moderate antibacterial activity was encountered in three of tested depsides, particularly with thielavin T, whose MIC was 6.25μg/mL against S. aureus.",
author = "{de Medeiros}, {L{\'i}via S.} and Abreu, {Lucas M.} and Anita Nielsen and Hanne Ingmer and Larsen, {Thomas O.} and Nielsen, {Kristian F.} and Edson Rodrigues-Filho",
note = "Copyright {\textcopyright} 2014 Elsevier Ltd. All rights reserved.",
year = "2015",
doi = "10.1016/j.phytochem.2014.12.020",
language = "English",
volume = "111",
pages = "154--162",
journal = "Phytochemistry",
issn = "0031-9422",
publisher = "Pergamon Press",

}

RIS

TY - JOUR

T1 - Dereplication-guided isolation of depsides thielavins S-T and lecanorins D-F from the endophytic fungus Setophoma sp.

AU - de Medeiros, Lívia S.

AU - Abreu, Lucas M.

AU - Nielsen, Anita

AU - Ingmer, Hanne

AU - Larsen, Thomas O.

AU - Nielsen, Kristian F.

AU - Rodrigues-Filho, Edson

N1 - Copyright © 2014 Elsevier Ltd. All rights reserved.

PY - 2015

Y1 - 2015

N2 - Dereplication methodology using UHPLC-DAD-QTOFMS was applied during the metabolic profiling investigation of the endophyte Setophoma sp., a fungus isolated from symptomless guava fruits. The approach performed allowed a fast analysis of the microbial secondary metabolites. From this fungus, seven highly C-alkylated depsides were isolated and identified as polyketides thielavins S, T, U and V and lecanorins D, E and F. Their structures were elucidated through spectroscopic methods including NMR, HRMS and especially with assistance of HRMS/MS experiments. The compounds were tested for quorum sensing regulation activity in the virulence gene expression of Staphylococcus aureus, but no inhibitory effect was detected. Nevertheless, moderate antibacterial activity was encountered in three of tested depsides, particularly with thielavin T, whose MIC was 6.25μg/mL against S. aureus.

AB - Dereplication methodology using UHPLC-DAD-QTOFMS was applied during the metabolic profiling investigation of the endophyte Setophoma sp., a fungus isolated from symptomless guava fruits. The approach performed allowed a fast analysis of the microbial secondary metabolites. From this fungus, seven highly C-alkylated depsides were isolated and identified as polyketides thielavins S, T, U and V and lecanorins D, E and F. Their structures were elucidated through spectroscopic methods including NMR, HRMS and especially with assistance of HRMS/MS experiments. The compounds were tested for quorum sensing regulation activity in the virulence gene expression of Staphylococcus aureus, but no inhibitory effect was detected. Nevertheless, moderate antibacterial activity was encountered in three of tested depsides, particularly with thielavin T, whose MIC was 6.25μg/mL against S. aureus.

U2 - 10.1016/j.phytochem.2014.12.020

DO - 10.1016/j.phytochem.2014.12.020

M3 - Journal article

C2 - 25586883

VL - 111

SP - 154

EP - 162

JO - Phytochemistry

JF - Phytochemistry

SN - 0031-9422

ER -

ID: 132896078