TY - JOUR

T1 - Effects of organohalogen pollutants on haematological and urine clinical-chemical parameters in Greenland sledge dogs (Canis familiaris)

AU - Sonne, Christian

AU - Dietz, Rune

AU - Kirkegaard, Maja

AU - Letcher, Robert J.

AU - Shahmiri, Soheila

AU - Andersen, Steen

AU - Møller, Per

AU - Olsen, Aage Kristian

AU - Jensen, Asger Lundorff

PY - 2008

Y1 - 2008

N2 - Seven West Greenland sledge dog bitches (Canis familiaris) and their three pups were fed 50-200 g of contaminated West Greenland minke whale (Balaenoptera acutorostrata) blubber, and in a control cohort eight sister bitches and their .ve pups were fed a similar amount pork fat. Blood plasma and urine clinical-chemical parameters were measured and compared between the bitches and pups form the control and exposed cohorts. Based on existing reference intervals, Arctic mammals may have blood clinical-chemical endpoint levels that differ from comparable species at lower latitudes. The cortisol:creatinine ratio, protein:creatinine ratio, alkaline phosphatase, cholesterol and inorganic phosphate were signi.cantly highest (ANCOVA: all po0:05) in the pup generation. The cortisol:creatinine ratio, cholesterol, lactate dehydrogenase and creatinine kinase were signi.cantly higher (ANCOVA: all po0:05) in the control group, while glucose was signi.cantly highest (ANCOVA: po0:05) in the exposed group. Furthermore, the blood cholesterol levels indicate that exposure via the diet to marine mammal blubber has a preventive effect on the development of cardiovascular diseases. We therefore suggest that the consumption of contaminated Arctic marine blubber impacted liver and kidney function in adult and pup sledge dogs.

AB - Seven West Greenland sledge dog bitches (Canis familiaris) and their three pups were fed 50-200 g of contaminated West Greenland minke whale (Balaenoptera acutorostrata) blubber, and in a control cohort eight sister bitches and their .ve pups were fed a similar amount pork fat. Blood plasma and urine clinical-chemical parameters were measured and compared between the bitches and pups form the control and exposed cohorts. Based on existing reference intervals, Arctic mammals may have blood clinical-chemical endpoint levels that differ from comparable species at lower latitudes. The cortisol:creatinine ratio, protein:creatinine ratio, alkaline phosphatase, cholesterol and inorganic phosphate were signi.cantly highest (ANCOVA: all po0:05) in the pup generation. The cortisol:creatinine ratio, cholesterol, lactate dehydrogenase and creatinine kinase were signi.cantly higher (ANCOVA: all po0:05) in the control group, while glucose was signi.cantly highest (ANCOVA: po0:05) in the exposed group. Furthermore, the blood cholesterol levels indicate that exposure via the diet to marine mammal blubber has a preventive effect on the development of cardiovascular diseases. We therefore suggest that the consumption of contaminated Arctic marine blubber impacted liver and kidney function in adult and pup sledge dogs.

KW - Former LIFE faculty

KW - Blood

KW - Cholesterol

KW - Cortisol:creatinine ratio

KW - Glucose

KW - Kidney

KW - Lactate dehydrogenase (LDH)

KW - Liver

KW - Polychlorinated biphenyls (PCBs)

KW - Sledge dogs

KW - Urine

U2 - 10.1016/j.ecoenv.2007.03.002

DO - 10.1016/j.ecoenv.2007.03.002

M3 - Journal article

C2 - 17434585

VL - 69

SP - 381

EP - 390

JO - Ecotoxicology and Environmental Safety

JF - Ecotoxicology and Environmental Safety

SN - 0147-6513

IS - 3

ER -