Enhancer evolution across 20 mammalian species
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Enhancer evolution across 20 mammalian species. / Villar, Diego; Berthelot, Camille; Aldridge, Sarah; Rayner, Tim F.; Lukk, Margus; Pignatelli, Miguel; Park, Thomas J.; Deaville, Robert; Erichsen, Jonathan T.; Jasinska, Anna J.; Turner, James M. A.; Bertelsen, Mads Frost; Murchison, Elizabeth P.; Flicek, Paul; Odom, Duncan T.
I: Cell, Bind 160, Nr. 3, 29.01.2015, s. 554-566.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Enhancer evolution across 20 mammalian species
AU - Villar, Diego
AU - Berthelot, Camille
AU - Aldridge, Sarah
AU - Rayner, Tim F.
AU - Lukk, Margus
AU - Pignatelli, Miguel
AU - Park, Thomas J.
AU - Deaville, Robert
AU - Erichsen, Jonathan T.
AU - Jasinska, Anna J.
AU - Turner, James M. A.
AU - Bertelsen, Mads Frost
AU - Murchison, Elizabeth P.
AU - Flicek, Paul
AU - Odom, Duncan T.
N1 - Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.
PY - 2015/1/29
Y1 - 2015/1/29
N2 - The mammalian radiation has corresponded with rapid changes in noncoding regions of the genome, but we lack a comprehensive understanding of regulatory evolution in mammals. Here, we track the evolution of promoters and enhancers active in liver across 20 mammalian species from six diverse orders by profiling genomic enrichment of H3K27 acetylation and H3K4 trimethylation. We report that rapid evolution of enhancers is a universal feature of mammalian genomes. Most of the recently evolved enhancers arise from ancestral DNA exaptation, rather than lineage-specific expansions of repeat elements. In contrast, almost all liver promoters are partially or fully conserved across these species. Our data further reveal that recently evolved enhancers can be associated with genes under positive selection, demonstrating the power of this approach for annotating regulatory adaptations in genomic sequences. These results provide important insight into the functional genetics underpinning mammalian regulatory evolution.
AB - The mammalian radiation has corresponded with rapid changes in noncoding regions of the genome, but we lack a comprehensive understanding of regulatory evolution in mammals. Here, we track the evolution of promoters and enhancers active in liver across 20 mammalian species from six diverse orders by profiling genomic enrichment of H3K27 acetylation and H3K4 trimethylation. We report that rapid evolution of enhancers is a universal feature of mammalian genomes. Most of the recently evolved enhancers arise from ancestral DNA exaptation, rather than lineage-specific expansions of repeat elements. In contrast, almost all liver promoters are partially or fully conserved across these species. Our data further reveal that recently evolved enhancers can be associated with genes under positive selection, demonstrating the power of this approach for annotating regulatory adaptations in genomic sequences. These results provide important insight into the functional genetics underpinning mammalian regulatory evolution.
KW - Animals
KW - Enhancer Elements, Genetic
KW - Evolution, Molecular
KW - Histone Code
KW - Humans
KW - Liver
KW - Mammals
KW - Promoter Regions, Genetic
KW - Transcription Factors
U2 - 10.1016/j.cell.2015.01.006
DO - 10.1016/j.cell.2015.01.006
M3 - Journal article
C2 - 25635462
VL - 160
SP - 554
EP - 566
JO - Cell
JF - Cell
SN - 0092-8674
IS - 3
ER -
ID: 146253186