Evaluation of diagnostic test procedures for SARS-CoV-2 using latent class models

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Evaluation of diagnostic test procedures for SARS-CoV-2 using latent class models. / Stærk-Østergaard, Jacob; Kirkeby, Carsten; Christiansen, Lasse E.; Andersen, Michael A.; Møller, Camilla H.; Voldstedlund, Marianne; Denwood, Matthew J.

I: Journal of Medical Virology, Bind 94, Nr. 10, 2022, s. 4754-4761.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Stærk-Østergaard, J, Kirkeby, C, Christiansen, LE, Andersen, MA, Møller, CH, Voldstedlund, M & Denwood, MJ 2022, 'Evaluation of diagnostic test procedures for SARS-CoV-2 using latent class models', Journal of Medical Virology, bind 94, nr. 10, s. 4754-4761. https://doi.org/10.1002/jmv.27943

APA

Stærk-Østergaard, J., Kirkeby, C., Christiansen, L. E., Andersen, M. A., Møller, C. H., Voldstedlund, M., & Denwood, M. J. (2022). Evaluation of diagnostic test procedures for SARS-CoV-2 using latent class models. Journal of Medical Virology, 94(10), 4754-4761. https://doi.org/10.1002/jmv.27943

Vancouver

Stærk-Østergaard J, Kirkeby C, Christiansen LE, Andersen MA, Møller CH, Voldstedlund M o.a. Evaluation of diagnostic test procedures for SARS-CoV-2 using latent class models. Journal of Medical Virology. 2022;94(10):4754-4761. https://doi.org/10.1002/jmv.27943

Author

Stærk-Østergaard, Jacob ; Kirkeby, Carsten ; Christiansen, Lasse E. ; Andersen, Michael A. ; Møller, Camilla H. ; Voldstedlund, Marianne ; Denwood, Matthew J. / Evaluation of diagnostic test procedures for SARS-CoV-2 using latent class models. I: Journal of Medical Virology. 2022 ; Bind 94, Nr. 10. s. 4754-4761.

Bibtex

@article{9e488b4e206544928d3dd4ec9e9e1321,
title = "Evaluation of diagnostic test procedures for SARS-CoV-2 using latent class models",
abstract = "Polymerase chain reaction (PCR) and antigen tests have been used extensively for screening during the severe acute respiratory syndrome coronavirus 2 pandemics. However, the real-world sensitivity and specificity of the two testing procedures in the field have not yet been estimated without assuming that the PCR constitutes a gold standard test. We use latent class models to estimate the in situ performance of both tests using data from the Danish national registries. We find that the specificity of both tests is very high (>99.7%), while the sensitivities are 95.7% (95% confidence interval [CI]: 92.8%–98.4%) and 53.8% (95% CI: 49.8%–57.9%) for the PCR and antigen tests, respectively. These findings have implications for the use of confirmatory PCR tests following a positive antigen test result: we estimate that serial testing is counterproductive at higher prevalence levels.",
keywords = "biostatistics and bioinformatics, epidemiology, SARS coronavirus, test statistics, virus classification",
author = "Jacob St{\ae}rk-{\O}stergaard and Carsten Kirkeby and Christiansen, {Lasse E.} and Andersen, {Michael A.} and M{\o}ller, {Camilla H.} and Marianne Voldstedlund and Denwood, {Matthew J.}",
note = "Publisher Copyright: {\textcopyright} 2022 The Authors. Journal of Medical Virology Published by Wiley Periodicals LLC.",
year = "2022",
doi = "10.1002/jmv.27943",
language = "English",
volume = "94",
pages = "4754--4761",
journal = "Journal of Medical Virology",
issn = "0146-6615",
publisher = "JohnWiley & Sons, Inc.",
number = "10",

}

RIS

TY - JOUR

T1 - Evaluation of diagnostic test procedures for SARS-CoV-2 using latent class models

AU - Stærk-Østergaard, Jacob

AU - Kirkeby, Carsten

AU - Christiansen, Lasse E.

AU - Andersen, Michael A.

AU - Møller, Camilla H.

AU - Voldstedlund, Marianne

AU - Denwood, Matthew J.

N1 - Publisher Copyright: © 2022 The Authors. Journal of Medical Virology Published by Wiley Periodicals LLC.

PY - 2022

Y1 - 2022

N2 - Polymerase chain reaction (PCR) and antigen tests have been used extensively for screening during the severe acute respiratory syndrome coronavirus 2 pandemics. However, the real-world sensitivity and specificity of the two testing procedures in the field have not yet been estimated without assuming that the PCR constitutes a gold standard test. We use latent class models to estimate the in situ performance of both tests using data from the Danish national registries. We find that the specificity of both tests is very high (>99.7%), while the sensitivities are 95.7% (95% confidence interval [CI]: 92.8%–98.4%) and 53.8% (95% CI: 49.8%–57.9%) for the PCR and antigen tests, respectively. These findings have implications for the use of confirmatory PCR tests following a positive antigen test result: we estimate that serial testing is counterproductive at higher prevalence levels.

AB - Polymerase chain reaction (PCR) and antigen tests have been used extensively for screening during the severe acute respiratory syndrome coronavirus 2 pandemics. However, the real-world sensitivity and specificity of the two testing procedures in the field have not yet been estimated without assuming that the PCR constitutes a gold standard test. We use latent class models to estimate the in situ performance of both tests using data from the Danish national registries. We find that the specificity of both tests is very high (>99.7%), while the sensitivities are 95.7% (95% confidence interval [CI]: 92.8%–98.4%) and 53.8% (95% CI: 49.8%–57.9%) for the PCR and antigen tests, respectively. These findings have implications for the use of confirmatory PCR tests following a positive antigen test result: we estimate that serial testing is counterproductive at higher prevalence levels.

KW - biostatistics and bioinformatics

KW - epidemiology

KW - SARS coronavirus

KW - test statistics

KW - virus classification

U2 - 10.1002/jmv.27943

DO - 10.1002/jmv.27943

M3 - Journal article

C2 - 35713189

AN - SCOPUS:85132385626

VL - 94

SP - 4754

EP - 4761

JO - Journal of Medical Virology

JF - Journal of Medical Virology

SN - 0146-6615

IS - 10

ER -

ID: 313376563