Failure to replicate? Exacerbated 8-OH-DPAT-induced hypothermia could not be established in single housed mice when tested as part of a battery of depression tests

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Failure to replicate? Exacerbated 8-OH-DPAT-induced hypothermia could not be established in single housed mice when tested as part of a battery of depression tests. / Skriver, Heidi; Kjær, Mille Reumert; Sørensen, Dorte Bratbo; Kalliokoski, Otto.

I: Scandinavian Journal of Laboratory Animal Science, Bind 45, 4, 2019, s. 1-11.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Skriver, H, Kjær, MR, Sørensen, DB & Kalliokoski, O 2019, 'Failure to replicate? Exacerbated 8-OH-DPAT-induced hypothermia could not be established in single housed mice when tested as part of a battery of depression tests', Scandinavian Journal of Laboratory Animal Science, bind 45, 4, s. 1-11. https://doi.org/10.23675/sjlas.v45i0.614

APA

Skriver, H., Kjær, M. R., Sørensen, D. B., & Kalliokoski, O. (2019). Failure to replicate? Exacerbated 8-OH-DPAT-induced hypothermia could not be established in single housed mice when tested as part of a battery of depression tests. Scandinavian Journal of Laboratory Animal Science, 45, 1-11. [4]. https://doi.org/10.23675/sjlas.v45i0.614

Vancouver

Skriver H, Kjær MR, Sørensen DB, Kalliokoski O. Failure to replicate? Exacerbated 8-OH-DPAT-induced hypothermia could not be established in single housed mice when tested as part of a battery of depression tests. Scandinavian Journal of Laboratory Animal Science. 2019;45:1-11. 4. https://doi.org/10.23675/sjlas.v45i0.614

Author

Skriver, Heidi ; Kjær, Mille Reumert ; Sørensen, Dorte Bratbo ; Kalliokoski, Otto. / Failure to replicate? Exacerbated 8-OH-DPAT-induced hypothermia could not be established in single housed mice when tested as part of a battery of depression tests. I: Scandinavian Journal of Laboratory Animal Science. 2019 ; Bind 45. s. 1-11.

Bibtex

@article{cd0fbe6cb0bb4606b0eeb4ca13171627,
title = "Failure to replicate? Exacerbated 8-OH-DPAT-induced hypothermia could not be established in single housed mice when tested as part of a battery of depression tests",
abstract = "We have previously described a depressive phenotype in male mice stemming from three weeks{\textquoteright} single housing, demonstrated as an exacerbated transient hypothermia following a challenge with the serotonin (5-HT) receptor agonist 8-OH-DPAT. In an attempt to flesh out the phenotype, we carried out a battery of tests used to assess depressive states on C57BL/6 mice of both sexes. When combining the 8-OH-DPAT challenge with the tail-suspension test, an open fieldtest, a sucrose preference test, and blood samplings for measuring serum levels of oxytocin, we could find no clear evidence of depressive states in the single housed animals. The fact thatwe could not replicate our previous findings is puzzling; however, we suspect that the stressful nature of the test battery may have been detrimental to the model. These negative findings and their implications may prove of significant importance moving forward with studying natural models of depression.",
author = "Heidi Skriver and Kj{\ae}r, {Mille Reumert} and S{\o}rensen, {Dorte Bratbo} and Otto Kalliokoski",
year = "2019",
doi = "10.23675/sjlas.v45i0.614",
language = "English",
volume = "45",
pages = "1--11",
journal = "Scandinavian Journal of Laboratory Animal Science",
issn = "0901-3393",
publisher = "R R Consult",

}

RIS

TY - JOUR

T1 - Failure to replicate? Exacerbated 8-OH-DPAT-induced hypothermia could not be established in single housed mice when tested as part of a battery of depression tests

AU - Skriver, Heidi

AU - Kjær, Mille Reumert

AU - Sørensen, Dorte Bratbo

AU - Kalliokoski, Otto

PY - 2019

Y1 - 2019

N2 - We have previously described a depressive phenotype in male mice stemming from three weeks’ single housing, demonstrated as an exacerbated transient hypothermia following a challenge with the serotonin (5-HT) receptor agonist 8-OH-DPAT. In an attempt to flesh out the phenotype, we carried out a battery of tests used to assess depressive states on C57BL/6 mice of both sexes. When combining the 8-OH-DPAT challenge with the tail-suspension test, an open fieldtest, a sucrose preference test, and blood samplings for measuring serum levels of oxytocin, we could find no clear evidence of depressive states in the single housed animals. The fact thatwe could not replicate our previous findings is puzzling; however, we suspect that the stressful nature of the test battery may have been detrimental to the model. These negative findings and their implications may prove of significant importance moving forward with studying natural models of depression.

AB - We have previously described a depressive phenotype in male mice stemming from three weeks’ single housing, demonstrated as an exacerbated transient hypothermia following a challenge with the serotonin (5-HT) receptor agonist 8-OH-DPAT. In an attempt to flesh out the phenotype, we carried out a battery of tests used to assess depressive states on C57BL/6 mice of both sexes. When combining the 8-OH-DPAT challenge with the tail-suspension test, an open fieldtest, a sucrose preference test, and blood samplings for measuring serum levels of oxytocin, we could find no clear evidence of depressive states in the single housed animals. The fact thatwe could not replicate our previous findings is puzzling; however, we suspect that the stressful nature of the test battery may have been detrimental to the model. These negative findings and their implications may prove of significant importance moving forward with studying natural models of depression.

U2 - 10.23675/sjlas.v45i0.614

DO - 10.23675/sjlas.v45i0.614

M3 - Journal article

VL - 45

SP - 1

EP - 11

JO - Scandinavian Journal of Laboratory Animal Science

JF - Scandinavian Journal of Laboratory Animal Science

SN - 0901-3393

M1 - 4

ER -

ID: 229271582