Genetic diversity and phylogenetic analysis of the attachment glycoprotein of phocine distemper viruses of the 2002 and 1988 epizootics

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  • Line Nielsen
  • Peter Arctander
  • Trine Hammer Jensen
  • Dietz, Hans Henrik
  • Anne Sofie Hammer
  • Ashley Banyard
  • Thomas Barrett
  • Merete Blixenkrone-Møller

To investigate the possible origin and spread of the dramatic re-emergent 2002 distemper epizootic

observed among seals in DanishWaters, we have sequenced wild-type genes of the attachment (H) glycoproteins

of viruses from both the 2002 and 1988 epizootics. Phylogenetic analysis of the H genes of

phocine distemper virus (PDV) together with other morbilliviruses, suggests that the re-emergent 2002

PDV is more closely related to a putative recent ancestral PDV than the 1988 PDV isolates. Moreover,

upsurges of distemper disease in land-living carnivores linked in time and locality to the 2002 seal epizootic

in Danish Waters was investigated and determined to be caused by canine distemper virus, the

closest relative of PDV, revealing no direct epidemiological link to the seal epizootics.

TidsskriftVirus Research
Udgave nummer1-2
Sider (fra-til)323-328
Antal sider6
StatusUdgivet - 2009

ID: 14308496