Genome wide association study of 40 clinical measurements in eight dog breeds
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Genome wide association study of 40 clinical measurements in eight dog breeds. / Momozawa, Yukihide; Merveille, Anne Christine; Battaille, Géraldine; Wiberg, Maria; Koch, Jørgen; Willesen, Jakob Lundgren; Proschowsky, Helle Friis; Gouni, Vassiliki; Chetboul, Valérie; Tiret, Laurent; Fredholm, Merete; Seppälä, Eija H.; Lohi, Hannes; Georges, Michel; Lequarré, Anne Sophie.
I: Scientific Reports, Bind 10, 6520, 2020.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Genome wide association study of 40 clinical measurements in eight dog breeds
AU - Momozawa, Yukihide
AU - Merveille, Anne Christine
AU - Battaille, Géraldine
AU - Wiberg, Maria
AU - Koch, Jørgen
AU - Willesen, Jakob Lundgren
AU - Proschowsky, Helle Friis
AU - Gouni, Vassiliki
AU - Chetboul, Valérie
AU - Tiret, Laurent
AU - Fredholm, Merete
AU - Seppälä, Eija H.
AU - Lohi, Hannes
AU - Georges, Michel
AU - Lequarré, Anne Sophie
PY - 2020
Y1 - 2020
N2 - The domestic dog represents an ideal model for identifying susceptibility genes, many of which are shared with humans. In this study, we investigated the genetic contribution to individual differences in 40 clinically important measurements by a genome-wide association study (GWAS) in a multinational cohort of 472 healthy dogs from eight breeds. Meta-analysis using the binary effects model after breed-specific GWAS, identified 13 genome-wide significant associations, three of them showed experimental-wide significant associations. We detected a signal at chromosome 13 for the serum concentration of alanine aminotransferase (ALT) in which we detected four breed-specific signals. A large proportion of the variance of ALT (18.1–47.7%) was explained by this locus. Similarly, a single SNP was also responsible for a large proportion of the variance (6.8–78.4%) for other measurements such as fructosamine, stress during physical exam, glucose, and morphometric measurements. The genetic contribution of single variant was much larger than in humans. These findings illustrate the importance of performing meta-analysis after breed-specific GWAS to reveal the genetic contribution to individual differences in clinically important measurements, which would lead to improvement of veterinary medicine.
AB - The domestic dog represents an ideal model for identifying susceptibility genes, many of which are shared with humans. In this study, we investigated the genetic contribution to individual differences in 40 clinically important measurements by a genome-wide association study (GWAS) in a multinational cohort of 472 healthy dogs from eight breeds. Meta-analysis using the binary effects model after breed-specific GWAS, identified 13 genome-wide significant associations, three of them showed experimental-wide significant associations. We detected a signal at chromosome 13 for the serum concentration of alanine aminotransferase (ALT) in which we detected four breed-specific signals. A large proportion of the variance of ALT (18.1–47.7%) was explained by this locus. Similarly, a single SNP was also responsible for a large proportion of the variance (6.8–78.4%) for other measurements such as fructosamine, stress during physical exam, glucose, and morphometric measurements. The genetic contribution of single variant was much larger than in humans. These findings illustrate the importance of performing meta-analysis after breed-specific GWAS to reveal the genetic contribution to individual differences in clinically important measurements, which would lead to improvement of veterinary medicine.
U2 - 10.1038/s41598-020-63457-y
DO - 10.1038/s41598-020-63457-y
M3 - Journal article
C2 - 32300138
AN - SCOPUS:85083631766
VL - 10
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
M1 - 6520
ER -
ID: 259673764