Genome-wide association study in Dachshund: identification of a major locus affecting intervertebral disc calcification
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Genome-wide association study in Dachshund : identification of a major locus affecting intervertebral disc calcification. / Mogensen, Mette Sloth; Karlskov-Mortensen, Peter; Proschowsky, Helle Friis; Lingaas, Frode; Lappalainen, Anu; Lohi, Hannes; Jensen, Vibeke Frøkjær; Fredholm, Merete.
I: Journal of Heredity, Bind 102, Nr. Suppl. 1, 2011, s. S81-S86.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Genome-wide association study in Dachshund
T2 - identification of a major locus affecting intervertebral disc calcification
AU - Mogensen, Mette Sloth
AU - Karlskov-Mortensen, Peter
AU - Proschowsky, Helle Friis
AU - Lingaas, Frode
AU - Lappalainen, Anu
AU - Lohi, Hannes
AU - Jensen, Vibeke Frøkjær
AU - Fredholm, Merete
PY - 2011
Y1 - 2011
N2 - Intervertebral disc calcification and herniation commonly affects Dachshund where the predisposition is caused by an early onset degenerative process resulting in disc calcification. A continuous spectrum of disc degeneration is seen within and among dog breeds, suggesting a multifactorial etiology. The number of calcified discs at 2 years of age determined by a radiographic evaluation is a good indicator of the severity of disc degeneration and thus serves as a measure for the risk of developing intervertebral disc herniation. The aim of the study was to identify genetic variants associated with intervertebral disc calcification in Dachshund through a genome-wide association (GWA) study. Based on thorough radiographic examinations, 48 cases with =6 disc calcifications or surgically treated for disc herniation and 46 controls with 0-1 disc calcifications were identified. GWA using the Illumina CanineHD BeadChip identified a locus on chromosome 12 from 36.8 to 38.6 Mb with 36 markers reaching genome-wide significance (P(genome) = 0.00001-0.026). This study suggests that a major locus on chromosome 12 harbors genetic variations affecting the development of intervertebral disc calcification in Dachshund.
AB - Intervertebral disc calcification and herniation commonly affects Dachshund where the predisposition is caused by an early onset degenerative process resulting in disc calcification. A continuous spectrum of disc degeneration is seen within and among dog breeds, suggesting a multifactorial etiology. The number of calcified discs at 2 years of age determined by a radiographic evaluation is a good indicator of the severity of disc degeneration and thus serves as a measure for the risk of developing intervertebral disc herniation. The aim of the study was to identify genetic variants associated with intervertebral disc calcification in Dachshund through a genome-wide association (GWA) study. Based on thorough radiographic examinations, 48 cases with =6 disc calcifications or surgically treated for disc herniation and 46 controls with 0-1 disc calcifications were identified. GWA using the Illumina CanineHD BeadChip identified a locus on chromosome 12 from 36.8 to 38.6 Mb with 36 markers reaching genome-wide significance (P(genome) = 0.00001-0.026). This study suggests that a major locus on chromosome 12 harbors genetic variations affecting the development of intervertebral disc calcification in Dachshund.
U2 - 10.1093/jhered/esr021
DO - 10.1093/jhered/esr021
M3 - Journal article
C2 - 21846751
VL - 102
SP - S81-S86
JO - Journal of Heredity
JF - Journal of Heredity
SN - 0022-1503
IS - Suppl. 1
ER -
ID: 34161663