Gut microbial markers are associated with diabetes onset, regulatory imbalance, and IFN-γ level in NOD mice

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Standard

Gut microbial markers are associated with diabetes onset, regulatory imbalance, and IFN-γ level in NOD mice. / Krych, Lukasz; Nielsen, Dennis Sandris; Hansen, Axel Kornerup; Hansen, Camilla Hartmann Friis.

I: Gut Microbes, Bind 6, Nr. 2, 2015, s. 101-109.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Krych, L, Nielsen, DS, Hansen, AK & Hansen, CHF 2015, 'Gut microbial markers are associated with diabetes onset, regulatory imbalance, and IFN-γ level in NOD mice', Gut Microbes, bind 6, nr. 2, s. 101-109. https://doi.org/10.1080/19490976.2015.1011876

APA

Krych, L., Nielsen, D. S., Hansen, A. K., & Hansen, C. H. F. (2015). Gut microbial markers are associated with diabetes onset, regulatory imbalance, and IFN-γ level in NOD mice. Gut Microbes, 6(2), 101-109. https://doi.org/10.1080/19490976.2015.1011876

Vancouver

Krych L, Nielsen DS, Hansen AK, Hansen CHF. Gut microbial markers are associated with diabetes onset, regulatory imbalance, and IFN-γ level in NOD mice. Gut Microbes. 2015;6(2):101-109. https://doi.org/10.1080/19490976.2015.1011876

Author

Krych, Lukasz ; Nielsen, Dennis Sandris ; Hansen, Axel Kornerup ; Hansen, Camilla Hartmann Friis. / Gut microbial markers are associated with diabetes onset, regulatory imbalance, and IFN-γ level in NOD mice. I: Gut Microbes. 2015 ; Bind 6, Nr. 2. s. 101-109.

Bibtex

@article{2787302949e74da3b5c6f6639c663626,
title = "Gut microbial markers are associated with diabetes onset, regulatory imbalance, and IFN-γ level in NOD mice",
abstract = "Gut microbiota regulated imbalances in the host's immune profile seem to be an important factor in the etiology of type 1 diabetes (T1D), and identifying bacterial markers for T1D may therefore be useful in diagnosis and prevention of T1D. The aim of the present study was to investigate the link between the early gut microbiota and immune parameters of non-obese diabetic (NOD) mice in order to select alleged bacterial markers of T1D. Gut microbial composition in feces was analyzed with 454/FLX Titanium (Roche) pyro-sequencing and correlated with diabetes onset age and immune cell populations measured in diabetic and non-diabetic mice at 30 weeks of age. The early gut microbiota composition was found to be different between NOD mice that later in life were classified as diabetic or non-diabetic. Those differences were further associated with changes in FoxP3(+) regulatory T cells, CD11b(+) dendritic cells, and IFN-γ production. The model proposed in this work suggests that operational taxonomic units classified to S24-7, Prevotella, and an unknown Bacteriodales (all Bacteroidetes) act in favor of diabetes protection whereas members of Lachnospiraceae, Ruminococcus, and Oscillospira (all Firmicutes) promote pathogenesis.",
author = "Lukasz Krych and Nielsen, {Dennis Sandris} and Hansen, {Axel Kornerup} and Hansen, {Camilla Hartmann Friis}",
year = "2015",
doi = "10.1080/19490976.2015.1011876",
language = "English",
volume = "6",
pages = "101--109",
journal = "Gut Microbes",
issn = "1949-0976",
publisher = "Taylor & Francis",
number = "2",

}

RIS

TY - JOUR

T1 - Gut microbial markers are associated with diabetes onset, regulatory imbalance, and IFN-γ level in NOD mice

AU - Krych, Lukasz

AU - Nielsen, Dennis Sandris

AU - Hansen, Axel Kornerup

AU - Hansen, Camilla Hartmann Friis

PY - 2015

Y1 - 2015

N2 - Gut microbiota regulated imbalances in the host's immune profile seem to be an important factor in the etiology of type 1 diabetes (T1D), and identifying bacterial markers for T1D may therefore be useful in diagnosis and prevention of T1D. The aim of the present study was to investigate the link between the early gut microbiota and immune parameters of non-obese diabetic (NOD) mice in order to select alleged bacterial markers of T1D. Gut microbial composition in feces was analyzed with 454/FLX Titanium (Roche) pyro-sequencing and correlated with diabetes onset age and immune cell populations measured in diabetic and non-diabetic mice at 30 weeks of age. The early gut microbiota composition was found to be different between NOD mice that later in life were classified as diabetic or non-diabetic. Those differences were further associated with changes in FoxP3(+) regulatory T cells, CD11b(+) dendritic cells, and IFN-γ production. The model proposed in this work suggests that operational taxonomic units classified to S24-7, Prevotella, and an unknown Bacteriodales (all Bacteroidetes) act in favor of diabetes protection whereas members of Lachnospiraceae, Ruminococcus, and Oscillospira (all Firmicutes) promote pathogenesis.

AB - Gut microbiota regulated imbalances in the host's immune profile seem to be an important factor in the etiology of type 1 diabetes (T1D), and identifying bacterial markers for T1D may therefore be useful in diagnosis and prevention of T1D. The aim of the present study was to investigate the link between the early gut microbiota and immune parameters of non-obese diabetic (NOD) mice in order to select alleged bacterial markers of T1D. Gut microbial composition in feces was analyzed with 454/FLX Titanium (Roche) pyro-sequencing and correlated with diabetes onset age and immune cell populations measured in diabetic and non-diabetic mice at 30 weeks of age. The early gut microbiota composition was found to be different between NOD mice that later in life were classified as diabetic or non-diabetic. Those differences were further associated with changes in FoxP3(+) regulatory T cells, CD11b(+) dendritic cells, and IFN-γ production. The model proposed in this work suggests that operational taxonomic units classified to S24-7, Prevotella, and an unknown Bacteriodales (all Bacteroidetes) act in favor of diabetes protection whereas members of Lachnospiraceae, Ruminococcus, and Oscillospira (all Firmicutes) promote pathogenesis.

U2 - 10.1080/19490976.2015.1011876

DO - 10.1080/19490976.2015.1011876

M3 - Journal article

C2 - 25648687

VL - 6

SP - 101

EP - 109

JO - Gut Microbes

JF - Gut Microbes

SN - 1949-0976

IS - 2

ER -

ID: 140387098