Health implications of chronic hepatosplenomegaly in Kenyan school-aged children chronically exposed to malarial infections and Schistosoma mansoni

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Health implications of chronic hepatosplenomegaly in Kenyan school-aged children chronically exposed to malarial infections and Schistosoma mansoni. / Wilson, Shona; Vennervald, Birgitte J; Kadzo, Hilda; Ireri, Edmund; Amaganga, Clifford; Booth, Mark; Kariuki, H. Curtis; Mwatha, Joseph K.; Kimani, Gachuhi; Ouma, John H.; Muchiri, Eric; Dunne, David W.

I: Transactions of the Royal Society of Tropical Medicine and Hygiene, Bind 104, Nr. 2, 2010, s. 110-116.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Wilson, S, Vennervald, BJ, Kadzo, H, Ireri, E, Amaganga, C, Booth, M, Kariuki, HC, Mwatha, JK, Kimani, G, Ouma, JH, Muchiri, E & Dunne, DW 2010, 'Health implications of chronic hepatosplenomegaly in Kenyan school-aged children chronically exposed to malarial infections and Schistosoma mansoni', Transactions of the Royal Society of Tropical Medicine and Hygiene, bind 104, nr. 2, s. 110-116. https://doi.org/10.1016/j.trstmh.2009.08.006

APA

Wilson, S., Vennervald, B. J., Kadzo, H., Ireri, E., Amaganga, C., Booth, M., Kariuki, H. C., Mwatha, J. K., Kimani, G., Ouma, J. H., Muchiri, E., & Dunne, D. W. (2010). Health implications of chronic hepatosplenomegaly in Kenyan school-aged children chronically exposed to malarial infections and Schistosoma mansoni. Transactions of the Royal Society of Tropical Medicine and Hygiene, 104(2), 110-116. https://doi.org/10.1016/j.trstmh.2009.08.006

Vancouver

Wilson S, Vennervald BJ, Kadzo H, Ireri E, Amaganga C, Booth M o.a. Health implications of chronic hepatosplenomegaly in Kenyan school-aged children chronically exposed to malarial infections and Schistosoma mansoni. Transactions of the Royal Society of Tropical Medicine and Hygiene. 2010;104(2):110-116. https://doi.org/10.1016/j.trstmh.2009.08.006

Author

Wilson, Shona ; Vennervald, Birgitte J ; Kadzo, Hilda ; Ireri, Edmund ; Amaganga, Clifford ; Booth, Mark ; Kariuki, H. Curtis ; Mwatha, Joseph K. ; Kimani, Gachuhi ; Ouma, John H. ; Muchiri, Eric ; Dunne, David W. / Health implications of chronic hepatosplenomegaly in Kenyan school-aged children chronically exposed to malarial infections and Schistosoma mansoni. I: Transactions of the Royal Society of Tropical Medicine and Hygiene. 2010 ; Bind 104, Nr. 2. s. 110-116.

Bibtex

@article{ef24a860f9fe11de825d000ea68e967b,
title = "Health implications of chronic hepatosplenomegaly in Kenyan school-aged children chronically exposed to malarial infections and Schistosoma mansoni",
abstract = "Hepatosplenomegaly among school-aged children in sub-Saharan Africa is highly prevalent. Two of the more common aetiological agents of hepatosplenomegaly, namely chronic exposure to malaria and Schistosoma mansoni infection, can result in similar clinical presentation, with the liver and spleen being chronically enlarged and of a firm consistency. Where co-endemic, the two parasites are thought to synergistically exacerbate hepatosplenomegaly. Here, two potential health consequences, i.e. dilation of the portal vein (indicative of increased portal pressure) and stunting of growth, were investigated in a study area where children were chronically exposed to malaria throughout while S. mansoni transmission was geographically restricted. Hepatosplenomegaly was associated with increased portal vein diameters, with enlargement of the spleen rather than the liver being more closely associated with dilation. Dilation of the portal vein was exacerbated by S. mansoni infection in an intensity-dependent manner. The prevalence of growth stunting was not associated with either relative exposure rates to malarial infection or with S. mansoni infection status but was significantly associated with hepatosplenomegaly. Children who presented with hepatosplenomegaly had the lowest height-for-age Z-scores. This study shows that hepatosplenomegaly associated with chronic exposure to malaria and schistosomiasis is not a benign symptom amongst school-aged children but has potential long-term health consequences.",
keywords = "Adolescent, Animals, Body Height, Child, Child, Preschool, Cohort Studies, Female, Growth Disorders, Hepatomegaly, Humans, Kenya, Malaria, Falciparum, Male, Schistosomiasis mansoni, Splenomegaly",
author = "Shona Wilson and Vennervald, {Birgitte J} and Hilda Kadzo and Edmund Ireri and Clifford Amaganga and Mark Booth and Kariuki, {H. Curtis} and Mwatha, {Joseph K.} and Gachuhi Kimani and Ouma, {John H.} and Eric Muchiri and Dunne, {David W.}",
note = "Copyright 2009 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.",
year = "2010",
doi = "10.1016/j.trstmh.2009.08.006",
language = "English",
volume = "104",
pages = "110--116",
journal = "Transactions of the Royal Society of Tropical Medicine and Hygiene",
issn = "0035-9203",
publisher = "Oxford University Press",
number = "2",

}

RIS

TY - JOUR

T1 - Health implications of chronic hepatosplenomegaly in Kenyan school-aged children chronically exposed to malarial infections and Schistosoma mansoni

AU - Wilson, Shona

AU - Vennervald, Birgitte J

AU - Kadzo, Hilda

AU - Ireri, Edmund

AU - Amaganga, Clifford

AU - Booth, Mark

AU - Kariuki, H. Curtis

AU - Mwatha, Joseph K.

AU - Kimani, Gachuhi

AU - Ouma, John H.

AU - Muchiri, Eric

AU - Dunne, David W.

N1 - Copyright 2009 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.

PY - 2010

Y1 - 2010

N2 - Hepatosplenomegaly among school-aged children in sub-Saharan Africa is highly prevalent. Two of the more common aetiological agents of hepatosplenomegaly, namely chronic exposure to malaria and Schistosoma mansoni infection, can result in similar clinical presentation, with the liver and spleen being chronically enlarged and of a firm consistency. Where co-endemic, the two parasites are thought to synergistically exacerbate hepatosplenomegaly. Here, two potential health consequences, i.e. dilation of the portal vein (indicative of increased portal pressure) and stunting of growth, were investigated in a study area where children were chronically exposed to malaria throughout while S. mansoni transmission was geographically restricted. Hepatosplenomegaly was associated with increased portal vein diameters, with enlargement of the spleen rather than the liver being more closely associated with dilation. Dilation of the portal vein was exacerbated by S. mansoni infection in an intensity-dependent manner. The prevalence of growth stunting was not associated with either relative exposure rates to malarial infection or with S. mansoni infection status but was significantly associated with hepatosplenomegaly. Children who presented with hepatosplenomegaly had the lowest height-for-age Z-scores. This study shows that hepatosplenomegaly associated with chronic exposure to malaria and schistosomiasis is not a benign symptom amongst school-aged children but has potential long-term health consequences.

AB - Hepatosplenomegaly among school-aged children in sub-Saharan Africa is highly prevalent. Two of the more common aetiological agents of hepatosplenomegaly, namely chronic exposure to malaria and Schistosoma mansoni infection, can result in similar clinical presentation, with the liver and spleen being chronically enlarged and of a firm consistency. Where co-endemic, the two parasites are thought to synergistically exacerbate hepatosplenomegaly. Here, two potential health consequences, i.e. dilation of the portal vein (indicative of increased portal pressure) and stunting of growth, were investigated in a study area where children were chronically exposed to malaria throughout while S. mansoni transmission was geographically restricted. Hepatosplenomegaly was associated with increased portal vein diameters, with enlargement of the spleen rather than the liver being more closely associated with dilation. Dilation of the portal vein was exacerbated by S. mansoni infection in an intensity-dependent manner. The prevalence of growth stunting was not associated with either relative exposure rates to malarial infection or with S. mansoni infection status but was significantly associated with hepatosplenomegaly. Children who presented with hepatosplenomegaly had the lowest height-for-age Z-scores. This study shows that hepatosplenomegaly associated with chronic exposure to malaria and schistosomiasis is not a benign symptom amongst school-aged children but has potential long-term health consequences.

KW - Adolescent

KW - Animals

KW - Body Height

KW - Child

KW - Child, Preschool

KW - Cohort Studies

KW - Female

KW - Growth Disorders

KW - Hepatomegaly

KW - Humans

KW - Kenya

KW - Malaria, Falciparum

KW - Male

KW - Schistosomiasis mansoni

KW - Splenomegaly

U2 - 10.1016/j.trstmh.2009.08.006

DO - 10.1016/j.trstmh.2009.08.006

M3 - Journal article

C2 - 19818465

VL - 104

SP - 110

EP - 116

JO - Transactions of the Royal Society of Tropical Medicine and Hygiene

JF - Transactions of the Royal Society of Tropical Medicine and Hygiene

SN - 0035-9203

IS - 2

ER -

ID: 16786560