Health promoting compounds in vegetables and fruits: A systematic approach for identifying plant components with impact on human health
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Vegetables contain unknown compounds with important health promoting effect. The described project defined and tested a two-step screening procedure for identification of such compounds. Step 1 is initial screening according to three criteria: 1.1, chemically reactive functional groups; 1.2, toxicity at high concentrations or other bioactivity; and 1.3, presence in healthy foods. Step 2 is testing for minimum criteria defining health-promoting compounds: 2.1, positive or biphasic ("hormesis") responses in bioassay; 2.2, human tissue concentrations corresponding to beneficial effects in bioassay; and 2.3, possibility to control content in food. Falcarinol from carrots fulfilled all 6 criteria and subsequently showed anticancer effect in rats.
Originalsprog | Engelsk |
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Tidsskrift | Trends in Food Science and Technology |
Vol/bind | 15 |
Udgave nummer | 7-8 |
Sider (fra-til) | 384-393 |
Antal sider | 10 |
ISSN | 0924-2244 |
DOI | |
Status | Udgivet - jul. 2004 |
Bibliografisk note
Funding Information:
The support of the Danish Research Council for Agricultural and Veterinary Research, Danish Food Technology Initiative (FØTEK 3) grant no. 2011-00-0040, is gratefully acknowledged.
ID: 316998846