Highly effective SNP-based association mapping and management of recessive defects in livestock
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Highly effective SNP-based association mapping and management of recessive defects in livestock. / Charlier, Carole; Coppieters, Wouter; Rollin, Frédéric; Desmecht, Daniel; Agerholm, Jørgen Steen; Cambisano, Nadine; Carta, Eloisa; Dardano, Sabrina; Dive, Marc; Fasquelle, Corinne; Frennet, Jean-Claude; Hanset, Roger; Hubin, Xavier; Jørgensen, Claus Bøttcher; Karim, Latifa; Kent, Matthew; Harvey, Kirsten; Pearce, Brian R.; Simon, Patricia; Tama, Nico; Nie, Haisheng; Vandeputte, Sébastien; Lien, Sigbjorn; Longeri, Maria; Fredholm, Merete; Harvey, Robert J.; Georges, Michel.
I: Nature Genetics, Bind 40, Nr. 4, 2008, s. 449-454.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Highly effective SNP-based association mapping and management of recessive defects in livestock
AU - Charlier, Carole
AU - Coppieters, Wouter
AU - Rollin, Frédéric
AU - Desmecht, Daniel
AU - Agerholm, Jørgen Steen
AU - Cambisano, Nadine
AU - Carta, Eloisa
AU - Dardano, Sabrina
AU - Dive, Marc
AU - Fasquelle, Corinne
AU - Frennet, Jean-Claude
AU - Hanset, Roger
AU - Hubin, Xavier
AU - Jørgensen, Claus Bøttcher
AU - Karim, Latifa
AU - Kent, Matthew
AU - Harvey, Kirsten
AU - Pearce, Brian R.
AU - Simon, Patricia
AU - Tama, Nico
AU - Nie, Haisheng
AU - Vandeputte, Sébastien
AU - Lien, Sigbjorn
AU - Longeri, Maria
AU - Fredholm, Merete
AU - Harvey, Robert J.
AU - Georges, Michel
PY - 2008
Y1 - 2008
N2 - The widespread use of elite sires by means of artificial insemination in livestock breeding leads to the frequent emergence of recessive genetic defects, which cause significant economic and animal welfare concerns. Here we show that the availability of genome-wide, high-density SNP panels, combined with the typical structure of livestock populations, markedly accelerates the positional identification of genes and mutations that cause inherited defects. We report the fine-scale mapping of five recessive disorders in cattle and the molecular basis for three of thee: congenital muscular dystony (CMD) types 1 and 2 in Belgian Blue cattle and ichthyosis fetalis in Italian Chianina cattle. Identification of these causative mutations has an immediate translation into breeding practive, allowing marker assisted selection against the defects through avoidance of at-risk matings.
AB - The widespread use of elite sires by means of artificial insemination in livestock breeding leads to the frequent emergence of recessive genetic defects, which cause significant economic and animal welfare concerns. Here we show that the availability of genome-wide, high-density SNP panels, combined with the typical structure of livestock populations, markedly accelerates the positional identification of genes and mutations that cause inherited defects. We report the fine-scale mapping of five recessive disorders in cattle and the molecular basis for three of thee: congenital muscular dystony (CMD) types 1 and 2 in Belgian Blue cattle and ichthyosis fetalis in Italian Chianina cattle. Identification of these causative mutations has an immediate translation into breeding practive, allowing marker assisted selection against the defects through avoidance of at-risk matings.
U2 - 10.1038/ng.96
DO - 10.1038/ng.96
M3 - Journal article
VL - 40
SP - 449
EP - 454
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 4
ER -
ID: 8104877