IMMUNE REGULATING ES-PRODUCTS IN PARASITIC NEMATODES

Publikation: Konferencebidrag › Konferenceabstrakt til konference › Forskning

Standard

IMMUNE REGULATING ES-PRODUCTS IN PARASITIC NEMATODES. / Bahlool, Qusay Zuhair Mohammad; Buchmann, Kurt; Kania, Per Walter; Skovgaard, Alf.

2013. Abstract fra DAFINET: Diagnosis and Control of Fish Diseases, Frederiksberg, Danmark.

Publikation: Konferencebidrag › Konferenceabstrakt til konference › Forskning

Harvard

Bahlool, QZM, Buchmann, K, Kania, PW & Skovgaard, A 2013, 'IMMUNE REGULATING ES-PRODUCTS IN PARASITIC NEMATODES', DAFINET: Diagnosis and Control of Fish Diseases, Frederiksberg, Danmark, 09/04/2013 - 11/04/2013.

APA

Bahlool, Q. Z. M., Buchmann, K., Kania, P. W., & Skovgaard, A. (2013). IMMUNE REGULATING ES-PRODUCTS IN PARASITIC NEMATODES. Abstract fra DAFINET: Diagnosis and Control of Fish Diseases, Frederiksberg, Danmark.

Vancouver

Bahlool QZM, Buchmann K, Kania PW, Skovgaard A. IMMUNE REGULATING ES-PRODUCTS IN PARASITIC NEMATODES. 2013. Abstract fra DAFINET: Diagnosis and Control of Fish Diseases, Frederiksberg, Danmark.

Author

Bahlool, Qusay Zuhair Mohammad ; Buchmann, Kurt ; Kania, Per Walter ; Skovgaard, Alf. / IMMUNE REGULATING ES-PRODUCTS IN PARASITIC NEMATODES. Abstract fra DAFINET: Diagnosis and Control of Fish Diseases, Frederiksberg, Danmark.

Bibtex

@conference{ad33269f7cb04d0b95e74a92b0a937a5,
title = "IMMUNE REGULATING ES-PRODUCTS IN PARASITIC NEMATODES",
abstract = "Excretory/secretory (ES) products are molecules including various proteins produced by parasitic nematodes including larval A. simplex which is occurring in numerous marine fish hosts. The function of these substances and their effect on host physiology has not been fully described. The present work elucidates the effect of ES substances on the fish immune system by measuring immune gene expression in spleen and liver of rainbow trout (Oncorhynchus mykiss) injectedintraperitoneally with ES products isolated from A. simplex third stage larvae. The overall gene expression profile of exposed fish showed a generalized down-regulation of the immune genes tested, suggesting a role of ES proteins in minimizing the immune reaction of rainbow trout against invading nematodes. We also tested the enzymatic activity of the ES proteins and found that lipase,esterase lipase, valine and cysteine arylamidases, naphthol-AS-BI-phosphohydrolase and a-galactosidase activities were present in the ES solution. This type of hydrolytic enzyme activity may play a role in nematode penetration of host tissue. Based on the notion that A. simplex ES-proteins may have an immune-depressive effect, it could also be suggested that worm enzymes directly target host immune effector molecules which would add to the decreased host immune responses and increased worm survival.",
author = "Bahlool, {Qusay Zuhair Mohammad} and Kurt Buchmann and Kania, {Per Walter} and Alf Skovgaard",
year = "2013",
month = apr,
language = "English",
note = "null ; Conference date: 09-04-2013 Through 11-04-2013",

}

RIS

TY - ABST

T1 - IMMUNE REGULATING ES-PRODUCTS IN PARASITIC NEMATODES

AU - Bahlool, Qusay Zuhair Mohammad

AU - Buchmann, Kurt

AU - Kania, Per Walter

AU - Skovgaard, Alf

PY - 2013/4

Y1 - 2013/4

N2 - Excretory/secretory (ES) products are molecules including various proteins produced by parasitic nematodes including larval A. simplex which is occurring in numerous marine fish hosts. The function of these substances and their effect on host physiology has not been fully described. The present work elucidates the effect of ES substances on the fish immune system by measuring immune gene expression in spleen and liver of rainbow trout (Oncorhynchus mykiss) injectedintraperitoneally with ES products isolated from A. simplex third stage larvae. The overall gene expression profile of exposed fish showed a generalized down-regulation of the immune genes tested, suggesting a role of ES proteins in minimizing the immune reaction of rainbow trout against invading nematodes. We also tested the enzymatic activity of the ES proteins and found that lipase,esterase lipase, valine and cysteine arylamidases, naphthol-AS-BI-phosphohydrolase and a-galactosidase activities were present in the ES solution. This type of hydrolytic enzyme activity may play a role in nematode penetration of host tissue. Based on the notion that A. simplex ES-proteins may have an immune-depressive effect, it could also be suggested that worm enzymes directly target host immune effector molecules which would add to the decreased host immune responses and increased worm survival.

AB - Excretory/secretory (ES) products are molecules including various proteins produced by parasitic nematodes including larval A. simplex which is occurring in numerous marine fish hosts. The function of these substances and their effect on host physiology has not been fully described. The present work elucidates the effect of ES substances on the fish immune system by measuring immune gene expression in spleen and liver of rainbow trout (Oncorhynchus mykiss) injectedintraperitoneally with ES products isolated from A. simplex third stage larvae. The overall gene expression profile of exposed fish showed a generalized down-regulation of the immune genes tested, suggesting a role of ES proteins in minimizing the immune reaction of rainbow trout against invading nematodes. We also tested the enzymatic activity of the ES proteins and found that lipase,esterase lipase, valine and cysteine arylamidases, naphthol-AS-BI-phosphohydrolase and a-galactosidase activities were present in the ES solution. This type of hydrolytic enzyme activity may play a role in nematode penetration of host tissue. Based on the notion that A. simplex ES-proteins may have an immune-depressive effect, it could also be suggested that worm enzymes directly target host immune effector molecules which would add to the decreased host immune responses and increased worm survival.

M3 - Conference abstract for conference

Y2 - 9 April 2013 through 11 April 2013

ER -

ID: 45694193