In vitro assessment of the ability of probiotics, blueberry and food carbohydrates to prevent S. pyogenes adhesion on pharyngeal epithelium and modulate immune responses

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Standard

In vitro assessment of the ability of probiotics, blueberry and food carbohydrates to prevent S. pyogenes adhesion on pharyngeal epithelium and modulate immune responses. / Taverniti, Valentina; Dalla Via, Alessandro; Minuzzo, Mario; Del Bo, Cristian; Riso, Patrizia; Frøkiær, Hanne; Guglielmetti, Simone.

I: Food & Function, Bind 8, Nr. 10, 2017, s. 3601-3609.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Taverniti, V, Dalla Via, A, Minuzzo, M, Del Bo, C, Riso, P, Frøkiær, H & Guglielmetti, S 2017, 'In vitro assessment of the ability of probiotics, blueberry and food carbohydrates to prevent S. pyogenes adhesion on pharyngeal epithelium and modulate immune responses', Food & Function, bind 8, nr. 10, s. 3601-3609. https://doi.org/10.1039/c7fo00829e

APA

Taverniti, V., Dalla Via, A., Minuzzo, M., Del Bo, C., Riso, P., Frøkiær, H., & Guglielmetti, S. (2017). In vitro assessment of the ability of probiotics, blueberry and food carbohydrates to prevent S. pyogenes adhesion on pharyngeal epithelium and modulate immune responses. Food & Function, 8(10), 3601-3609. https://doi.org/10.1039/c7fo00829e

Vancouver

Taverniti V, Dalla Via A, Minuzzo M, Del Bo C, Riso P, Frøkiær H o.a. In vitro assessment of the ability of probiotics, blueberry and food carbohydrates to prevent S. pyogenes adhesion on pharyngeal epithelium and modulate immune responses. Food & Function. 2017;8(10):3601-3609. https://doi.org/10.1039/c7fo00829e

Author

Taverniti, Valentina ; Dalla Via, Alessandro ; Minuzzo, Mario ; Del Bo, Cristian ; Riso, Patrizia ; Frøkiær, Hanne ; Guglielmetti, Simone. / In vitro assessment of the ability of probiotics, blueberry and food carbohydrates to prevent S. pyogenes adhesion on pharyngeal epithelium and modulate immune responses. I: Food & Function. 2017 ; Bind 8, Nr. 10. s. 3601-3609.

Bibtex

@article{cf78891d491b4d5f92478ff51007bb44,
title = "In vitro assessment of the ability of probiotics, blueberry and food carbohydrates to prevent S. pyogenes adhesion on pharyngeal epithelium and modulate immune responses",
abstract = "Group A streptococci (GAS) cause 20-30% of pediatric pharyngitis episodes, which are a major cause of ambulatory care visits. Therefore, a strategy to prevent GAS dissemination in children could significantly benefit public healthcare. Contextually, we assessed the possibility of employing alternative food-grade strategies to be used with the oral probiotic L. helveticus MIMLh5 for the prevention of pharyngeal infections. First, we demonstrated through an antagonism-by-exclusion assay that guaran may potentially prevent S. pyogenes adhesion on pharyngeal cells. Subsequently, we showed that an anthocyanin-rich fraction extracted from wild blueberry (BbE) exerts anti-inflammatory effects on the human macrophage cell line U937. Finally, we showed that BbE reduces interferon-β expression in MIMLh5-stimulated murine dendritic cells, resulting in a reduction in the pro-inflammatory cytokines IL-12 and TNF-α. In conclusion, this proof-of-concept study indicates that different food-grade strategies may be concomitantly adopted to potentially prevent GAS colonization and modulate local immune defences.",
author = "Valentina Taverniti and {Dalla Via}, Alessandro and Mario Minuzzo and {Del Bo}, Cristian and Patrizia Riso and Hanne Fr{\o}ki{\ae}r and Simone Guglielmetti",
year = "2017",
doi = "10.1039/c7fo00829e",
language = "English",
volume = "8",
pages = "3601--3609",
journal = "Food & Function",
issn = "2042-6496",
publisher = "Royal Society of Chemistry",
number = "10",

}

RIS

TY - JOUR

T1 - In vitro assessment of the ability of probiotics, blueberry and food carbohydrates to prevent S. pyogenes adhesion on pharyngeal epithelium and modulate immune responses

AU - Taverniti, Valentina

AU - Dalla Via, Alessandro

AU - Minuzzo, Mario

AU - Del Bo, Cristian

AU - Riso, Patrizia

AU - Frøkiær, Hanne

AU - Guglielmetti, Simone

PY - 2017

Y1 - 2017

N2 - Group A streptococci (GAS) cause 20-30% of pediatric pharyngitis episodes, which are a major cause of ambulatory care visits. Therefore, a strategy to prevent GAS dissemination in children could significantly benefit public healthcare. Contextually, we assessed the possibility of employing alternative food-grade strategies to be used with the oral probiotic L. helveticus MIMLh5 for the prevention of pharyngeal infections. First, we demonstrated through an antagonism-by-exclusion assay that guaran may potentially prevent S. pyogenes adhesion on pharyngeal cells. Subsequently, we showed that an anthocyanin-rich fraction extracted from wild blueberry (BbE) exerts anti-inflammatory effects on the human macrophage cell line U937. Finally, we showed that BbE reduces interferon-β expression in MIMLh5-stimulated murine dendritic cells, resulting in a reduction in the pro-inflammatory cytokines IL-12 and TNF-α. In conclusion, this proof-of-concept study indicates that different food-grade strategies may be concomitantly adopted to potentially prevent GAS colonization and modulate local immune defences.

AB - Group A streptococci (GAS) cause 20-30% of pediatric pharyngitis episodes, which are a major cause of ambulatory care visits. Therefore, a strategy to prevent GAS dissemination in children could significantly benefit public healthcare. Contextually, we assessed the possibility of employing alternative food-grade strategies to be used with the oral probiotic L. helveticus MIMLh5 for the prevention of pharyngeal infections. First, we demonstrated through an antagonism-by-exclusion assay that guaran may potentially prevent S. pyogenes adhesion on pharyngeal cells. Subsequently, we showed that an anthocyanin-rich fraction extracted from wild blueberry (BbE) exerts anti-inflammatory effects on the human macrophage cell line U937. Finally, we showed that BbE reduces interferon-β expression in MIMLh5-stimulated murine dendritic cells, resulting in a reduction in the pro-inflammatory cytokines IL-12 and TNF-α. In conclusion, this proof-of-concept study indicates that different food-grade strategies may be concomitantly adopted to potentially prevent GAS colonization and modulate local immune defences.

U2 - 10.1039/c7fo00829e

DO - 10.1039/c7fo00829e

M3 - Journal article

C2 - 28891576

AN - SCOPUS:85031784486

VL - 8

SP - 3601

EP - 3609

JO - Food & Function

JF - Food & Function

SN - 2042-6496

IS - 10

ER -

ID: 185414087