Infection, recovery and re-infection of farmed mink with SARS-CoV-2

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Infection, recovery and re-infection of farmed mink with SARS-CoV-2. / Rasmussen, Thomas Bruun; Fonager, Jannik; Jørgensen, Charlotte Sværke; Lassaunière, Ria; Hammer, Anne Sofie; Quaade, Michelle Lauge; Boklund, Anette; Lohse, Louise; Strandbygaard, Bertel; Rasmussen, Morten; Michaelsen, Thomas Yssing; Mortensen, Sten; Fomsgaard, Anders; Belsham, Graham J.; Bøtner, Anette.

I: PLOS Pathogens, Bind 17, Nr. 11, e1010068, 2021.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Rasmussen, TB, Fonager, J, Jørgensen, CS, Lassaunière, R, Hammer, AS, Quaade, ML, Boklund, A, Lohse, L, Strandbygaard, B, Rasmussen, M, Michaelsen, TY, Mortensen, S, Fomsgaard, A, Belsham, GJ & Bøtner, A 2021, 'Infection, recovery and re-infection of farmed mink with SARS-CoV-2', PLOS Pathogens, bind 17, nr. 11, e1010068. https://doi.org/10.1371/journal.ppat.1010068

APA

Rasmussen, T. B., Fonager, J., Jørgensen, C. S., Lassaunière, R., Hammer, A. S., Quaade, M. L., Boklund, A., Lohse, L., Strandbygaard, B., Rasmussen, M., Michaelsen, T. Y., Mortensen, S., Fomsgaard, A., Belsham, G. J., & Bøtner, A. (2021). Infection, recovery and re-infection of farmed mink with SARS-CoV-2. PLOS Pathogens, 17(11), [e1010068]. https://doi.org/10.1371/journal.ppat.1010068

Vancouver

Rasmussen TB, Fonager J, Jørgensen CS, Lassaunière R, Hammer AS, Quaade ML o.a. Infection, recovery and re-infection of farmed mink with SARS-CoV-2. PLOS Pathogens. 2021;17(11). e1010068. https://doi.org/10.1371/journal.ppat.1010068

Author

Rasmussen, Thomas Bruun ; Fonager, Jannik ; Jørgensen, Charlotte Sværke ; Lassaunière, Ria ; Hammer, Anne Sofie ; Quaade, Michelle Lauge ; Boklund, Anette ; Lohse, Louise ; Strandbygaard, Bertel ; Rasmussen, Morten ; Michaelsen, Thomas Yssing ; Mortensen, Sten ; Fomsgaard, Anders ; Belsham, Graham J. ; Bøtner, Anette. / Infection, recovery and re-infection of farmed mink with SARS-CoV-2. I: PLOS Pathogens. 2021 ; Bind 17, Nr. 11.

Bibtex

@article{b492d07fb68946608991db5a09010c63,
title = "Infection, recovery and re-infection of farmed mink with SARS-CoV-2",
abstract = "Mink, on a farm with about 15,000 animals, became infected with SARS-CoV-2. Over 75% of tested animals were positive for SARS-CoV-2 RNA in throat swabs and 100% of tested animals were seropositive. The virus responsible had a deletion of nucleotides encoding residues H69 and V70 within the spike protein gene as well as the A22920T mutation, resulting in the Y453F substitution within this protein, seen previously in mink. The infected mink recovered and after free-testing of 300 mink (a level giving 93% confidence of detecting a 1% prevalence), the animals remained seropositive. During further follow-up studies, after a period of more than 2 months without any virus detection, over 75% of tested animals again scored positive for SARS-CoV-2 RNA. Whole genome sequencing showed that the viruses circulating during this re-infection were most closely related to those identified in the first outbreak on this farm but additional sequence changes had occurred. Animals had much higher levels of anti-SARS-CoV-2 antibodies in serum samples after the second round of infection than at free-testing or during recovery from initial infection, consistent with a boosted immune response. Thus, it was concluded that following recovery from an initial infection, seropositive mink were readily re-infected by SARS-CoV-2. ",
author = "Rasmussen, {Thomas Bruun} and Jannik Fonager and J{\o}rgensen, {Charlotte Sv{\ae}rke} and Ria Lassauni{\`e}re and Hammer, {Anne Sofie} and Quaade, {Michelle Lauge} and Anette Boklund and Louise Lohse and Bertel Strandbygaard and Morten Rasmussen and Michaelsen, {Thomas Yssing} and Sten Mortensen and Anders Fomsgaard and Belsham, {Graham J.} and Anette B{\o}tner",
note = "Publisher Copyright: {\textcopyright} 2021 Rasmussen et al.",
year = "2021",
doi = "10.1371/journal.ppat.1010068",
language = "English",
volume = "17",
journal = "P L o S Pathogens",
issn = "1553-7366",
publisher = "Public Library of Science",
number = "11",

}

RIS

TY - JOUR

T1 - Infection, recovery and re-infection of farmed mink with SARS-CoV-2

AU - Rasmussen, Thomas Bruun

AU - Fonager, Jannik

AU - Jørgensen, Charlotte Sværke

AU - Lassaunière, Ria

AU - Hammer, Anne Sofie

AU - Quaade, Michelle Lauge

AU - Boklund, Anette

AU - Lohse, Louise

AU - Strandbygaard, Bertel

AU - Rasmussen, Morten

AU - Michaelsen, Thomas Yssing

AU - Mortensen, Sten

AU - Fomsgaard, Anders

AU - Belsham, Graham J.

AU - Bøtner, Anette

N1 - Publisher Copyright: © 2021 Rasmussen et al.

PY - 2021

Y1 - 2021

N2 - Mink, on a farm with about 15,000 animals, became infected with SARS-CoV-2. Over 75% of tested animals were positive for SARS-CoV-2 RNA in throat swabs and 100% of tested animals were seropositive. The virus responsible had a deletion of nucleotides encoding residues H69 and V70 within the spike protein gene as well as the A22920T mutation, resulting in the Y453F substitution within this protein, seen previously in mink. The infected mink recovered and after free-testing of 300 mink (a level giving 93% confidence of detecting a 1% prevalence), the animals remained seropositive. During further follow-up studies, after a period of more than 2 months without any virus detection, over 75% of tested animals again scored positive for SARS-CoV-2 RNA. Whole genome sequencing showed that the viruses circulating during this re-infection were most closely related to those identified in the first outbreak on this farm but additional sequence changes had occurred. Animals had much higher levels of anti-SARS-CoV-2 antibodies in serum samples after the second round of infection than at free-testing or during recovery from initial infection, consistent with a boosted immune response. Thus, it was concluded that following recovery from an initial infection, seropositive mink were readily re-infected by SARS-CoV-2.

AB - Mink, on a farm with about 15,000 animals, became infected with SARS-CoV-2. Over 75% of tested animals were positive for SARS-CoV-2 RNA in throat swabs and 100% of tested animals were seropositive. The virus responsible had a deletion of nucleotides encoding residues H69 and V70 within the spike protein gene as well as the A22920T mutation, resulting in the Y453F substitution within this protein, seen previously in mink. The infected mink recovered and after free-testing of 300 mink (a level giving 93% confidence of detecting a 1% prevalence), the animals remained seropositive. During further follow-up studies, after a period of more than 2 months without any virus detection, over 75% of tested animals again scored positive for SARS-CoV-2 RNA. Whole genome sequencing showed that the viruses circulating during this re-infection were most closely related to those identified in the first outbreak on this farm but additional sequence changes had occurred. Animals had much higher levels of anti-SARS-CoV-2 antibodies in serum samples after the second round of infection than at free-testing or during recovery from initial infection, consistent with a boosted immune response. Thus, it was concluded that following recovery from an initial infection, seropositive mink were readily re-infected by SARS-CoV-2.

U2 - 10.1371/journal.ppat.1010068

DO - 10.1371/journal.ppat.1010068

M3 - Journal article

C2 - 34780574

AN - SCOPUS:85119930268

VL - 17

JO - P L o S Pathogens

JF - P L o S Pathogens

SN - 1553-7366

IS - 11

M1 - e1010068

ER -

ID: 286630831