Interbreed variation of biomarkers of lipid and glucose metabolism in dogs
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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Interbreed variation of biomarkers of lipid and glucose metabolism in dogs. / Gomez-fernandez-blanco, Carlos; Peeters, Dominique; Moyse, Evelyne; Farnir, Frédéric; Höglund, Katja; Gouni, Vassiliki; Wiberg, Maria; Lundgren Willesen, Jakob; Hanås, Sofia; Mcentee, Kathleen; Tiret, Laurent; Häggström, Jens; Lohi, Hannes; Chetboul, Valérie; Fredholm, Merete; Seppälä, Eija H; Lequarré, Anne-sophie; Merveille, Anne-christine.
I: Veterinary Clinical Pathology, Bind 47, Nr. 4, 2018, s. 582-588.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Interbreed variation of biomarkers of lipid and glucose metabolism in dogs
AU - Gomez-fernandez-blanco, Carlos
AU - Peeters, Dominique
AU - Moyse, Evelyne
AU - Farnir, Frédéric
AU - Höglund, Katja
AU - Gouni, Vassiliki
AU - Wiberg, Maria
AU - Lundgren Willesen, Jakob
AU - Hanås, Sofia
AU - Mcentee, Kathleen
AU - Tiret, Laurent
AU - Häggström, Jens
AU - Lohi, Hannes
AU - Chetboul, Valérie
AU - Fredholm, Merete
AU - Seppälä, Eija H
AU - Lequarré, Anne-sophie
AU - Merveille, Anne-christine
PY - 2018
Y1 - 2018
N2 - BackgroundMarkers of lipid and glucose metabolism are used in both clinical practice and research. Detection of abnormal laboratory results often relies on species‐specific reference intervals, but interbreed variation can also affect data interpretation.ObjectivesThe purpose of the present study was to compare concentrations of selected biochemical variables among different dog breeds.MethodsWe analyzed a database containing information on biochemical variables from 534 dogs belonging to nine different breeds. All dogs were confirmed to be healthy based on history, physical examination, and ancillary tests. Concentrations of glucose, fructosamine, insulin, cholesterol, triglycerides, fatty acids, and C‐reactive protein were compared using the nonparametric Kruskal–Wallis and Dunn's tests.ResultsAll variables tested showed significant interbreed differences, although all breeds remained within the previously established RIs for dogs. Fructosamine, insulin, and cholesterol showed a wide interbreed variation that could affect the interpretation of results.ConclusionsBreed is an important factor to consider when assessing energy metabolism in dogs, especially for markers like fructosamine, insulin, and cholesterol, which vary considerably among breeds.
AB - BackgroundMarkers of lipid and glucose metabolism are used in both clinical practice and research. Detection of abnormal laboratory results often relies on species‐specific reference intervals, but interbreed variation can also affect data interpretation.ObjectivesThe purpose of the present study was to compare concentrations of selected biochemical variables among different dog breeds.MethodsWe analyzed a database containing information on biochemical variables from 534 dogs belonging to nine different breeds. All dogs were confirmed to be healthy based on history, physical examination, and ancillary tests. Concentrations of glucose, fructosamine, insulin, cholesterol, triglycerides, fatty acids, and C‐reactive protein were compared using the nonparametric Kruskal–Wallis and Dunn's tests.ResultsAll variables tested showed significant interbreed differences, although all breeds remained within the previously established RIs for dogs. Fructosamine, insulin, and cholesterol showed a wide interbreed variation that could affect the interpretation of results.ConclusionsBreed is an important factor to consider when assessing energy metabolism in dogs, especially for markers like fructosamine, insulin, and cholesterol, which vary considerably among breeds.
U2 - 10.1111/vcp.12673
DO - 10.1111/vcp.12673
M3 - Journal article
C2 - 30556915
VL - 47
SP - 582
EP - 588
JO - Veterinary Clinical Pathology
JF - Veterinary Clinical Pathology
SN - 0275-6382
IS - 4
ER -
ID: 222325492