Late gestational nutrient restriction: effects on ewes' metabolic and homeorhetic adaptation, consequences for lamb birth weight and lactation performance
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Late gestational nutrient restriction : effects on ewes' metabolic and homeorhetic adaptation, consequences for lamb birth weight and lactation performance. / Tygesen, Malin Plumhoff; Nielsen, Mette Olaf; Nørgaard, Peder; Ranvig, Hans; Harrison, Adrian Paul; Tauson, Anne-Helene.
I: Archives of Animal Nutrition, Bind 62, Nr. 1, 2008, s. 44-59.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Late gestational nutrient restriction
T2 - effects on ewes' metabolic and homeorhetic adaptation, consequences for lamb birth weight and lactation performance
AU - Tygesen, Malin Plumhoff
AU - Nielsen, Mette Olaf
AU - Nørgaard, Peder
AU - Ranvig, Hans
AU - Harrison, Adrian Paul
AU - Tauson, Anne-Helene
PY - 2008
Y1 - 2008
N2 - We investigated the effect of 50% nutrient restriction during the last 6 weeks of gestation on twin-pregnant ewes' plasma glucose, non-esterified fatty acid, ß-hydroxybutyrate, insulin, IGF-1 and leptin concentrations and the effects on lamb birth weight and ewes' lactation performance. Plasma metabolite and hormone concentrations in restricted ewes suggest that maternal tissues were being mobilised. Despite the ewes' adaptations their lambs weighed significantly less at birth. Furthermore, colostrum and milk yields were markedly reduced up until the latest measurement at 3 weeks post partum despite adlibitum access to feed. Reduced milk yields coincided with reduced plasma IGF-1 concentration pre partum in nutrient restricted ewes indicating, that mammary gland development may have been compromised. The present data suggest that leptin is not involved in the regulation of early lactation changes in feed intake and energy balance. It is concluded that severely reduced nutrient availability in late gestation affects fetal growth in utero and has a prolonged negative effect on lactation performance.
AB - We investigated the effect of 50% nutrient restriction during the last 6 weeks of gestation on twin-pregnant ewes' plasma glucose, non-esterified fatty acid, ß-hydroxybutyrate, insulin, IGF-1 and leptin concentrations and the effects on lamb birth weight and ewes' lactation performance. Plasma metabolite and hormone concentrations in restricted ewes suggest that maternal tissues were being mobilised. Despite the ewes' adaptations their lambs weighed significantly less at birth. Furthermore, colostrum and milk yields were markedly reduced up until the latest measurement at 3 weeks post partum despite adlibitum access to feed. Reduced milk yields coincided with reduced plasma IGF-1 concentration pre partum in nutrient restricted ewes indicating, that mammary gland development may have been compromised. The present data suggest that leptin is not involved in the regulation of early lactation changes in feed intake and energy balance. It is concluded that severely reduced nutrient availability in late gestation affects fetal growth in utero and has a prolonged negative effect on lactation performance.
KW - Former LIFE faculty
KW - glucose
KW - ß-hydroxybutyrate
KW - non-esterified fatty acids
KW - insulin
KW - insulin-like growth factor-1
KW - leptin
KW - milk yield
U2 - 10.1080/17450390701780276
DO - 10.1080/17450390701780276
M3 - Journal article
VL - 62
SP - 44
EP - 59
JO - Archives of Animal Nutrition
JF - Archives of Animal Nutrition
SN - 1745-039X
IS - 1
ER -
ID: 8094978