LUPA: a European initiative taking advantage of the canine genome architecture for unravelling complex disorders in both human and dogs

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LUPA : a European initiative taking advantage of the canine genome architecture for unravelling complex disorders in both human and dogs. / Lequarré, Anne-Sophie; Andersson, Leif; André, Catherine; Fredholm, Merete; Hitte, Christophe; Leeb, Tosso; Lohi, Hannes; Lindblad-Toh, Kerstin; Georges, Michel.

I: The Veterinary Journal, Bind 189, Nr. 2, 2011, s. 155-159.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Lequarré, A-S, Andersson, L, André, C, Fredholm, M, Hitte, C, Leeb, T, Lohi, H, Lindblad-Toh, K & Georges, M 2011, 'LUPA: a European initiative taking advantage of the canine genome architecture for unravelling complex disorders in both human and dogs', The Veterinary Journal, bind 189, nr. 2, s. 155-159. https://doi.org/10.1016/j.tvjl.2011.06.013

APA

Lequarré, A-S., Andersson, L., André, C., Fredholm, M., Hitte, C., Leeb, T., Lohi, H., Lindblad-Toh, K., & Georges, M. (2011). LUPA: a European initiative taking advantage of the canine genome architecture for unravelling complex disorders in both human and dogs. The Veterinary Journal, 189(2), 155-159. https://doi.org/10.1016/j.tvjl.2011.06.013

Vancouver

Lequarré A-S, Andersson L, André C, Fredholm M, Hitte C, Leeb T o.a. LUPA: a European initiative taking advantage of the canine genome architecture for unravelling complex disorders in both human and dogs. The Veterinary Journal. 2011;189(2):155-159. https://doi.org/10.1016/j.tvjl.2011.06.013

Author

Lequarré, Anne-Sophie ; Andersson, Leif ; André, Catherine ; Fredholm, Merete ; Hitte, Christophe ; Leeb, Tosso ; Lohi, Hannes ; Lindblad-Toh, Kerstin ; Georges, Michel. / LUPA : a European initiative taking advantage of the canine genome architecture for unravelling complex disorders in both human and dogs. I: The Veterinary Journal. 2011 ; Bind 189, Nr. 2. s. 155-159.

Bibtex

@article{2658fa0aefed4e9a94f9be41f3aff8e3,
title = "LUPA: a European initiative taking advantage of the canine genome architecture for unravelling complex disorders in both human and dogs",
abstract = "The domestic dog offers a unique opportunity to explore the genetic basis of disease, morphology and behaviour. Humans share many diseases with our canine companions, making dogs an ideal model organism for comparative disease genetics. Using newly developed resources, genome-wide association studies in dog breeds are proving to be exceptionally powerful. Towards this aim, veterinarians and geneticists from 12 European countries are collaborating to collect and analyse the DNA from large cohorts of dogs suffering from a range of carefully defined diseases of relevance to human health. This project, named LUPA, has already delivered considerable results. The consortium has collaborated to develop a new high density single nucleotide polymorphism (SNP) array. Mutations for four monogenic diseases have been identified and the information has been utilised to find mutations in human patients. Several complex diseases have been mapped and fine mapping is underway. These findings should ultimately lead to a better understanding of the molecular mechanisms underlying complex diseases in both humans and their best friend.",
author = "Anne-Sophie Lequarr{\'e} and Leif Andersson and Catherine Andr{\'e} and Merete Fredholm and Christophe Hitte and Tosso Leeb and Hannes Lohi and Kerstin Lindblad-Toh and Michel Georges",
year = "2011",
doi = "10.1016/j.tvjl.2011.06.013",
language = "English",
volume = "189",
pages = "155--159",
journal = "The Veterinary Journal",
issn = "1090-0233",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - LUPA

T2 - a European initiative taking advantage of the canine genome architecture for unravelling complex disorders in both human and dogs

AU - Lequarré, Anne-Sophie

AU - Andersson, Leif

AU - André, Catherine

AU - Fredholm, Merete

AU - Hitte, Christophe

AU - Leeb, Tosso

AU - Lohi, Hannes

AU - Lindblad-Toh, Kerstin

AU - Georges, Michel

PY - 2011

Y1 - 2011

N2 - The domestic dog offers a unique opportunity to explore the genetic basis of disease, morphology and behaviour. Humans share many diseases with our canine companions, making dogs an ideal model organism for comparative disease genetics. Using newly developed resources, genome-wide association studies in dog breeds are proving to be exceptionally powerful. Towards this aim, veterinarians and geneticists from 12 European countries are collaborating to collect and analyse the DNA from large cohorts of dogs suffering from a range of carefully defined diseases of relevance to human health. This project, named LUPA, has already delivered considerable results. The consortium has collaborated to develop a new high density single nucleotide polymorphism (SNP) array. Mutations for four monogenic diseases have been identified and the information has been utilised to find mutations in human patients. Several complex diseases have been mapped and fine mapping is underway. These findings should ultimately lead to a better understanding of the molecular mechanisms underlying complex diseases in both humans and their best friend.

AB - The domestic dog offers a unique opportunity to explore the genetic basis of disease, morphology and behaviour. Humans share many diseases with our canine companions, making dogs an ideal model organism for comparative disease genetics. Using newly developed resources, genome-wide association studies in dog breeds are proving to be exceptionally powerful. Towards this aim, veterinarians and geneticists from 12 European countries are collaborating to collect and analyse the DNA from large cohorts of dogs suffering from a range of carefully defined diseases of relevance to human health. This project, named LUPA, has already delivered considerable results. The consortium has collaborated to develop a new high density single nucleotide polymorphism (SNP) array. Mutations for four monogenic diseases have been identified and the information has been utilised to find mutations in human patients. Several complex diseases have been mapped and fine mapping is underway. These findings should ultimately lead to a better understanding of the molecular mechanisms underlying complex diseases in both humans and their best friend.

U2 - 10.1016/j.tvjl.2011.06.013

DO - 10.1016/j.tvjl.2011.06.013

M3 - Journal article

VL - 189

SP - 155

EP - 159

JO - The Veterinary Journal

JF - The Veterinary Journal

SN - 1090-0233

IS - 2

ER -

ID: 34164861