TY - JOUR

T1 - Maximum levels of cross-contamination for 24 antimicrobial active substances in non-target feed. Part 12: Tetracyclines: tetracycline, chlortetracycline, oxytetracycline, and doxycycline

AU - EFSA Panel on Biological Hazards (BIOHAZ), null

AU - Koutsoumanis, Konstantinos

AU - Allende, Ana

AU - Alvarez-Ordóñez, Avelino

AU - Bolton, Declan

AU - Bover-Cid, Sara

AU - Chemaly, Marianne

AU - Davies, Robert

AU - De Cesare, Alessandra

AU - Herman, Lieve

AU - Hilbert, Friederike

AU - Lindqvist, Roland

AU - Nauta, Maarten

AU - Ru, Giuseppe

AU - Simmons, Marion

AU - Skandamis, Panagiotis

AU - Suffredini, Elisabetta

AU - Andersson, Dan I

AU - Bampidis, Vasileios

AU - Bengtsson-Palme, Johan

AU - Bouchard, Damien

AU - Ferran, Aude

AU - Kouba, Maryline

AU - López Puente, Secundino

AU - López-Alonso, Marta

AU - Nielsen, Søren Saxmose

AU - Pechová, Alena

AU - Petkova, Mariana

AU - Girault, Sebastien

AU - Broglia, Alessandro

AU - Guerra, Beatriz

AU - Innocenti, Matteo Lorenzo

AU - Liébana, Ernesto

AU - López-Gálvez, Gloria

AU - Manini, Paola

AU - Stella, Pietro

AU - Peixe, Luisa

PY - 2021/10/26

Y1 - 2021/10/26

N2 - Abstract The specific concentrations of tetracycline, chlortetracycline, oxytetracycline and doxycycline in non-target feed for food-producing animals, below which there would not be an effect on the emergence of, and/or selection for, resistance in bacteria relevant for human and animal health, as well as the specific antimicrobial concentrations in feed which have an effect in terms of growth promotion/increased yield were assessed by EFSA in collaboration with EMA. Details of the methodology used for this assessment, associated data gaps and uncertainties are presented in a separate document. To address antimicrobial resistance, the Feed Antimicrobial Resistance Selection Concentration (FARSC) model developed specifically for the assessment was applied. The FARSC for these four tetracyclines was estimated. To address growth promotion, data from scientific publications obtained from an extensive literature review were used. Levels in feed that showed to have an effect on growth promotion/increased yield were reported for tetracycline, chlortetracycline, oxytetracycline, whilst for doxycycline no suitable data for the assessment were available. Uncertainties and data gaps associated with the levels reported were addressed. It was recommended to perform further studies to supply more diverse and complete data related to the requirements for calculation of the FARSC for these antimicrobials.

AB - Abstract The specific concentrations of tetracycline, chlortetracycline, oxytetracycline and doxycycline in non-target feed for food-producing animals, below which there would not be an effect on the emergence of, and/or selection for, resistance in bacteria relevant for human and animal health, as well as the specific antimicrobial concentrations in feed which have an effect in terms of growth promotion/increased yield were assessed by EFSA in collaboration with EMA. Details of the methodology used for this assessment, associated data gaps and uncertainties are presented in a separate document. To address antimicrobial resistance, the Feed Antimicrobial Resistance Selection Concentration (FARSC) model developed specifically for the assessment was applied. The FARSC for these four tetracyclines was estimated. To address growth promotion, data from scientific publications obtained from an extensive literature review were used. Levels in feed that showed to have an effect on growth promotion/increased yield were reported for tetracycline, chlortetracycline, oxytetracycline, whilst for doxycycline no suitable data for the assessment were available. Uncertainties and data gaps associated with the levels reported were addressed. It was recommended to perform further studies to supply more diverse and complete data related to the requirements for calculation of the FARSC for these antimicrobials.

KW - tetracycline

KW - chlortetracycline

KW - oxytetracycline

KW - doxycycline

KW - antimicrobial resistance

KW - growth promotion

KW - food-producing animals

U2 - 10.2903/j.efsa.2021.6864

DO - 10.2903/j.efsa.2021.6864

M3 - Journal article

C2 - 34729092

VL - 19

SP - 1

EP - 116

JO - E F S A Journal

JF - E F S A Journal

SN - 1831-4732

IS - 10

M1 - e06864

ER -