Mebendazole treatment persistently alters the size profile and morphology of Trichuris trichiura eggs

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Standard

Mebendazole treatment persistently alters the size profile and morphology of Trichuris trichiura eggs. / Nejsum, Peter; Andersen, Kasper Lind; Andersen, Sidsel Dahl; Thamsborg, Stig Milan; Tejedor, Ana Merino.

I: Acta Tropica, Bind 204, 105347, 2020.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Nejsum, P, Andersen, KL, Andersen, SD, Thamsborg, SM & Tejedor, AM 2020, 'Mebendazole treatment persistently alters the size profile and morphology of Trichuris trichiura eggs', Acta Tropica, bind 204, 105347. https://doi.org/10.1016/j.actatropica.2020.105347

APA

Nejsum, P., Andersen, K. L., Andersen, S. D., Thamsborg, S. M., & Tejedor, A. M. (2020). Mebendazole treatment persistently alters the size profile and morphology of Trichuris trichiura eggs. Acta Tropica, 204, [105347]. https://doi.org/10.1016/j.actatropica.2020.105347

Vancouver

Nejsum P, Andersen KL, Andersen SD, Thamsborg SM, Tejedor AM. Mebendazole treatment persistently alters the size profile and morphology of Trichuris trichiura eggs. Acta Tropica. 2020;204. 105347. https://doi.org/10.1016/j.actatropica.2020.105347

Author

Nejsum, Peter ; Andersen, Kasper Lind ; Andersen, Sidsel Dahl ; Thamsborg, Stig Milan ; Tejedor, Ana Merino. / Mebendazole treatment persistently alters the size profile and morphology of Trichuris trichiura eggs. I: Acta Tropica. 2020 ; Bind 204.

Bibtex

@article{42897e69fd2549f9a84dcee2bb7f9eff,
title = "Mebendazole treatment persistently alters the size profile and morphology of Trichuris trichiura eggs",
abstract = "The soil transmitted whipworm, Trichuris trichiura affects about half a billion people globally. Diagnosis is based on identification of characteristic lemon-shaped eggs in stool samples. Occasionally large Trichuris eggs have been reported and have been ascribed to variation within T. trichiura or zoonotic infection with T. vulpis from dogs. We observed that the egg size profile changed markedly after anthelmintic treatment, and remained so, in a human individual self-infected with T. trichiura. The large eggs were detected with two standard diagnostic methods, Kato-Katz thick smear and salt-flotation (McMaster) method. It is therefore important to bear in mind that the morphology of parasite eggs may vary, e.g. in response to previous drug treatment. Large Trichuris eggs in human stool samples should not be diagnosed as T. vulpis infection without confirmation by other means.",
keywords = "Anthelmintic treatment, Diagnostics, Egg size, Kato Katz, McMaster, Trichuris trichiura",
author = "Peter Nejsum and Andersen, {Kasper Lind} and Andersen, {Sidsel Dahl} and Thamsborg, {Stig Milan} and Tejedor, {Ana Merino}",
year = "2020",
doi = "10.1016/j.actatropica.2020.105347",
language = "English",
volume = "204",
journal = "Acta Tropica",
issn = "0001-706X",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Mebendazole treatment persistently alters the size profile and morphology of Trichuris trichiura eggs

AU - Nejsum, Peter

AU - Andersen, Kasper Lind

AU - Andersen, Sidsel Dahl

AU - Thamsborg, Stig Milan

AU - Tejedor, Ana Merino

PY - 2020

Y1 - 2020

N2 - The soil transmitted whipworm, Trichuris trichiura affects about half a billion people globally. Diagnosis is based on identification of characteristic lemon-shaped eggs in stool samples. Occasionally large Trichuris eggs have been reported and have been ascribed to variation within T. trichiura or zoonotic infection with T. vulpis from dogs. We observed that the egg size profile changed markedly after anthelmintic treatment, and remained so, in a human individual self-infected with T. trichiura. The large eggs were detected with two standard diagnostic methods, Kato-Katz thick smear and salt-flotation (McMaster) method. It is therefore important to bear in mind that the morphology of parasite eggs may vary, e.g. in response to previous drug treatment. Large Trichuris eggs in human stool samples should not be diagnosed as T. vulpis infection without confirmation by other means.

AB - The soil transmitted whipworm, Trichuris trichiura affects about half a billion people globally. Diagnosis is based on identification of characteristic lemon-shaped eggs in stool samples. Occasionally large Trichuris eggs have been reported and have been ascribed to variation within T. trichiura or zoonotic infection with T. vulpis from dogs. We observed that the egg size profile changed markedly after anthelmintic treatment, and remained so, in a human individual self-infected with T. trichiura. The large eggs were detected with two standard diagnostic methods, Kato-Katz thick smear and salt-flotation (McMaster) method. It is therefore important to bear in mind that the morphology of parasite eggs may vary, e.g. in response to previous drug treatment. Large Trichuris eggs in human stool samples should not be diagnosed as T. vulpis infection without confirmation by other means.

KW - Anthelmintic treatment

KW - Diagnostics

KW - Egg size

KW - Kato Katz

KW - McMaster

KW - Trichuris trichiura

U2 - 10.1016/j.actatropica.2020.105347

DO - 10.1016/j.actatropica.2020.105347

M3 - Journal article

C2 - 31954684

AN - SCOPUS:85079357102

VL - 204

JO - Acta Tropica

JF - Acta Tropica

SN - 0001-706X

M1 - 105347

ER -

ID: 236714846