MicroRNA expression profiling of the porcine developing brain
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MicroRNA expression profiling of the porcine developing brain. / Podolska, Agnieszka; Kaczkowski, Bogumil; Busk, Peter Kamp; Søkilde, Rolf; Litman, Thomas; Fredholm, Merete; Cirera Salicio, Susanna.
I: P L o S One, Bind 6, 2011, s. e14494.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - MicroRNA expression profiling of the porcine developing brain
AU - Podolska, Agnieszka
AU - Kaczkowski, Bogumil
AU - Busk, Peter Kamp
AU - Søkilde, Rolf
AU - Litman, Thomas
AU - Fredholm, Merete
AU - Cirera Salicio, Susanna
PY - 2011
Y1 - 2011
N2 - MicroRNAs are small, non-coding RNA molecules that regulate gene expression at the post-transcriptional level and play an important role in the control of developmental and physiological processes. In particular, the developing brain contains an impressive diversity of microRNAs. Most microRNA expression profiling studies have been performed in human or rodents and relatively limited knowledge exists in other mammalian species. The domestic pig is considered to be an excellent, alternate, large mammal model for human-related neurological studies, due to its similarity in both brain development and the growth curve when compared to humans. Considering these similarities, studies examining microRNA expression during porcine brain development could potentially be used to predict the expression profile and role of microRNAs in the human brain.
AB - MicroRNAs are small, non-coding RNA molecules that regulate gene expression at the post-transcriptional level and play an important role in the control of developmental and physiological processes. In particular, the developing brain contains an impressive diversity of microRNAs. Most microRNA expression profiling studies have been performed in human or rodents and relatively limited knowledge exists in other mammalian species. The domestic pig is considered to be an excellent, alternate, large mammal model for human-related neurological studies, due to its similarity in both brain development and the growth curve when compared to humans. Considering these similarities, studies examining microRNA expression during porcine brain development could potentially be used to predict the expression profile and role of microRNAs in the human brain.
U2 - 10.1371/journal.pone.0014494
DO - 10.1371/journal.pone.0014494
M3 - Journal article
C2 - 21253018
VL - 6
SP - e14494
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
ER -
ID: 35250135