Organomegaly in Mali before and after praziquantel treatment. A possible association with Schistosoma haematobium
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Organomegaly in Mali before and after praziquantel treatment. A possible association with Schistosoma haematobium. / Stecher, Chalotte Willemann; Madsen, Henry; Wilson, Shona; Sacko, Moussa; Wejse, Christian; Keita, Adama D.; Landouré, Aly; Traoré, Mamadou S.; Kallestrup, Per; Petersen, Eskild; Vennervald, Birgitte.
I: Heliyon, Bind 3, Nr. 11, e00440, 11.2017.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Organomegaly in Mali before and after praziquantel treatment. A possible association with Schistosoma haematobium
AU - Stecher, Chalotte Willemann
AU - Madsen, Henry
AU - Wilson, Shona
AU - Sacko, Moussa
AU - Wejse, Christian
AU - Keita, Adama D.
AU - Landouré, Aly
AU - Traoré, Mamadou S.
AU - Kallestrup, Per
AU - Petersen, Eskild
AU - Vennervald, Birgitte
PY - 2017/11
Y1 - 2017/11
N2 - Continuous exposure to schistosome-infested water results in acute and chronic morbidity in all ages. We analysed occurence of organomegaly via ultrasonography and investigated a possible additive effect of dual-dose drug administration in 401 Schistosoma haematobium infected individuals from a highly endemic area in Mali. Mean intensity of infection at baseline (22.0 eggs per 10 ml) was reduced to 0.22 eggs per 10 ml 9 weeks after treatment (both treatments combined). Odds of persistent infection among those given dual-dose treatment was 41% of that in people given single dose (b = 0.41; p = 0.05; 95% CI 0.17–1.00), but after two years, 70.7% of the 157 participants, who completed the survey, were re-infected with no significant difference in prevalence and intensity of infection between treatment groups. Resolution of organomegaly occurred in all age groups after treatment. A novel association between Schistosoma haematobium infection and moderate portal vein enlargement was found in 35% (n: 55). Severe portal vein diameter enlargement was found in 3.2%. After two years, moderate hepatomegaly was present in 50.6%, moderate splenomegaly in 45.6% and moderate portal vein diameter enlargement in 19%. A subsequent dose of PZQ did not provide any additional long-term advantages.
AB - Continuous exposure to schistosome-infested water results in acute and chronic morbidity in all ages. We analysed occurence of organomegaly via ultrasonography and investigated a possible additive effect of dual-dose drug administration in 401 Schistosoma haematobium infected individuals from a highly endemic area in Mali. Mean intensity of infection at baseline (22.0 eggs per 10 ml) was reduced to 0.22 eggs per 10 ml 9 weeks after treatment (both treatments combined). Odds of persistent infection among those given dual-dose treatment was 41% of that in people given single dose (b = 0.41; p = 0.05; 95% CI 0.17–1.00), but after two years, 70.7% of the 157 participants, who completed the survey, were re-infected with no significant difference in prevalence and intensity of infection between treatment groups. Resolution of organomegaly occurred in all age groups after treatment. A novel association between Schistosoma haematobium infection and moderate portal vein enlargement was found in 35% (n: 55). Severe portal vein diameter enlargement was found in 3.2%. After two years, moderate hepatomegaly was present in 50.6%, moderate splenomegaly in 45.6% and moderate portal vein diameter enlargement in 19%. A subsequent dose of PZQ did not provide any additional long-term advantages.
KW - Infectious disease
U2 - 10.1016/j.heliyon.2017.e00440
DO - 10.1016/j.heliyon.2017.e00440
M3 - Journal article
C2 - 29264407
AN - SCOPUS:85033726971
VL - 3
JO - Heliyon
JF - Heliyon
SN - 2405-8440
IS - 11
M1 - e00440
ER -
ID: 192449117