Pathogenesis and infection dynamics of high pathogenicity avian influenza virus (HPAIV) H5N6 (clade 2.3.4.4b) in pheasants and onward transmission to chickens
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Dokumenter
- Fulltext
Forlagets udgivne version, 12,7 MB, PDF-dokument
High pathogenicity avian influenza viruses clade 2.3.4.4 H5 have spread among wild birds worldwide during recent years causing annual die-offs among wild birds and outbreaks in poultry in multiple European countries. The outbreaks significantly impact the poultry and game bird sectors. Infected game birds may act as a bridging species potentially enabling spread of virus into commercial and backyard premises. In this study, the pathogenesis and transmission of a HPAIV clade 2.3.4.4b H5N6 virus was investigated in pheasants and chickens. Efficient virus transmission was detected between pheasants over multiple rounds of naïve pheasant introductions and onwards to chickens. Mortality of up to 100% was observed for both infected pheasants and chickens. Intra-species transmission from chicken to chicken was less efficient. The study confirmed that clade 2.3.4.4b H5N6 HPAIV is highly virulent in pheasants and emphasises the role of pheasants as a bridging host for the infection of commercial poultry.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Virology |
| Vol/bind | 577 |
| Sider (fra-til) | 138-148 |
| Antal sider | 11 |
| ISSN | 0042-6822 |
| DOI | |
| Status | Udgivet - 2022 |
Bibliografisk note
Funding Information:
Amanda H. Seekings, Caroline J. Warren, Joe James, Saumya S. Thomas, Ashley C. Banyard, Marek J. Slomka, and Ian H. Brown were funded by the UK Department for Environment, Food & Rural Affairs (DEFRA) and the devolved Scottish and Welsh administrations, grant numbers SE2213 and SV3006. The study was funded by the Danish Veterinary and Food Administration.The authors would like to thank the animal carers and pathology scientists at APHA for their support in animal husbandry and tissue processing, respectively, as well as laboratory technician Sari Mia Dose from SSI for assistance on the project.
Funding Information:
Amanda H. Seekings, Caroline J. Warren, Joe James, Saumya S. Thomas, Ashley C. Banyard, Marek J. Slomka, and Ian H. Brown were funded by the UK Department for Environment, Food & Rural Affairs (DEFRA) and the devolved Scottish and Welsh administrations, grant numbers SE2213 and SV3006 . The study was funded by the Danish Veterinary and Food Administration .
Publisher Copyright:
© 2022
Antal downloads er baseret på statistik fra Google Scholar og www.ku.dk
ID: 330917342