Pathogenicity and genomic changes of a 2016 European H5N8 highly pathogenic avian influenza virus (clade 2.3.4.4) in experimentally infected mallards and chickens

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Pathogenicity and genomic changes of a 2016 European H5N8 highly pathogenic avian influenza virus (clade 2.3.4.4) in experimentally infected mallards and chickens. / Leyson, Christina; Youk, Sung-Su; Smith, Diane; Dimitrov, Kiril; Lee, Dong-Hun; Larsen, Lars Erik; Swayne, David E; Pantin-Jackwood, Mary J.

I: Virology, Bind 537, 2019, s. 172-185.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Leyson, C, Youk, S-S, Smith, D, Dimitrov, K, Lee, D-H, Larsen, LE, Swayne, DE & Pantin-Jackwood, MJ 2019, 'Pathogenicity and genomic changes of a 2016 European H5N8 highly pathogenic avian influenza virus (clade 2.3.4.4) in experimentally infected mallards and chickens', Virology, bind 537, s. 172-185. https://doi.org/10.1016/j.virol.2019.08.020

APA

Leyson, C., Youk, S-S., Smith, D., Dimitrov, K., Lee, D-H., Larsen, L. E., Swayne, D. E., & Pantin-Jackwood, M. J. (2019). Pathogenicity and genomic changes of a 2016 European H5N8 highly pathogenic avian influenza virus (clade 2.3.4.4) in experimentally infected mallards and chickens. Virology, 537, 172-185. https://doi.org/10.1016/j.virol.2019.08.020

Vancouver

Leyson C, Youk S-S, Smith D, Dimitrov K, Lee D-H, Larsen LE o.a. Pathogenicity and genomic changes of a 2016 European H5N8 highly pathogenic avian influenza virus (clade 2.3.4.4) in experimentally infected mallards and chickens. Virology. 2019;537:172-185. https://doi.org/10.1016/j.virol.2019.08.020

Author

Leyson, Christina ; Youk, Sung-Su ; Smith, Diane ; Dimitrov, Kiril ; Lee, Dong-Hun ; Larsen, Lars Erik ; Swayne, David E ; Pantin-Jackwood, Mary J. / Pathogenicity and genomic changes of a 2016 European H5N8 highly pathogenic avian influenza virus (clade 2.3.4.4) in experimentally infected mallards and chickens. I: Virology. 2019 ; Bind 537. s. 172-185.

Bibtex

@article{d0b47b1b85744330b41c50a06e5aef86,
title = "Pathogenicity and genomic changes of a 2016 European H5N8 highly pathogenic avian influenza virus (clade 2.3.4.4) in experimentally infected mallards and chickens",
abstract = "Highly pathogenic avian influenza H5N8 clade 2.3.4.4 virus caused outbreaks in poultry and unusually high mortality in wild birds in 2016-2017. The pathobiology of one of these viruses was examined in mallards and chickens. High mortality and transmission to direct contacts were observed in mallards inoculated with medium and high doses of the virus. However, in chickens, high mortality occurred only when birds are given the high virus dose and no transmission was observed, indicating that the virus was better adapted to mallards. In comparison with the virus inoculum, viral sequences obtained from the chickens had a higher number of nucleotide changes but lower intra-host genomic diversity than viral sequences obtained from the mallards. These observations are consistent with population bottlenecks occurring when viruses infect and replicate in a host that it is not well adapted to. Whether these observations apply to influenza viruses in general remains to be determined.",
author = "Christina Leyson and Sung-Su Youk and Diane Smith and Kiril Dimitrov and Dong-Hun Lee and Larsen, {Lars Erik} and Swayne, {David E} and Pantin-Jackwood, {Mary J}",
note = "Published by Elsevier Inc.",
year = "2019",
doi = "10.1016/j.virol.2019.08.020",
language = "English",
volume = "537",
pages = "172--185",
journal = "Virology",
issn = "0042-6822",
publisher = "Academic Press",

}

RIS

TY - JOUR

T1 - Pathogenicity and genomic changes of a 2016 European H5N8 highly pathogenic avian influenza virus (clade 2.3.4.4) in experimentally infected mallards and chickens

AU - Leyson, Christina

AU - Youk, Sung-Su

AU - Smith, Diane

AU - Dimitrov, Kiril

AU - Lee, Dong-Hun

AU - Larsen, Lars Erik

AU - Swayne, David E

AU - Pantin-Jackwood, Mary J

N1 - Published by Elsevier Inc.

PY - 2019

Y1 - 2019

N2 - Highly pathogenic avian influenza H5N8 clade 2.3.4.4 virus caused outbreaks in poultry and unusually high mortality in wild birds in 2016-2017. The pathobiology of one of these viruses was examined in mallards and chickens. High mortality and transmission to direct contacts were observed in mallards inoculated with medium and high doses of the virus. However, in chickens, high mortality occurred only when birds are given the high virus dose and no transmission was observed, indicating that the virus was better adapted to mallards. In comparison with the virus inoculum, viral sequences obtained from the chickens had a higher number of nucleotide changes but lower intra-host genomic diversity than viral sequences obtained from the mallards. These observations are consistent with population bottlenecks occurring when viruses infect and replicate in a host that it is not well adapted to. Whether these observations apply to influenza viruses in general remains to be determined.

AB - Highly pathogenic avian influenza H5N8 clade 2.3.4.4 virus caused outbreaks in poultry and unusually high mortality in wild birds in 2016-2017. The pathobiology of one of these viruses was examined in mallards and chickens. High mortality and transmission to direct contacts were observed in mallards inoculated with medium and high doses of the virus. However, in chickens, high mortality occurred only when birds are given the high virus dose and no transmission was observed, indicating that the virus was better adapted to mallards. In comparison with the virus inoculum, viral sequences obtained from the chickens had a higher number of nucleotide changes but lower intra-host genomic diversity than viral sequences obtained from the mallards. These observations are consistent with population bottlenecks occurring when viruses infect and replicate in a host that it is not well adapted to. Whether these observations apply to influenza viruses in general remains to be determined.

U2 - 10.1016/j.virol.2019.08.020

DO - 10.1016/j.virol.2019.08.020

M3 - Journal article

C2 - 31493656

VL - 537

SP - 172

EP - 185

JO - Virology

JF - Virology

SN - 0042-6822

ER -

ID: 238858729