Permanent catheterization of the carotid artery induces kidney infection and inflammation in the rat

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Standard

Permanent catheterization of the carotid artery induces kidney infection and inflammation in the rat. / Fonseca, Uno Nicolas Kjærup; Nielsen, Sanne Gram; Hau, Jann; Hansen, Axel Jacob Kornerup.

I: Laboratory Animals. Journal of the Laboratory Animal Science Association, Bind 44, Nr. 1, 2010, s. 46-53.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Fonseca, UNK, Nielsen, SG, Hau, J & Hansen, AJK 2010, 'Permanent catheterization of the carotid artery induces kidney infection and inflammation in the rat', Laboratory Animals. Journal of the Laboratory Animal Science Association, bind 44, nr. 1, s. 46-53. https://doi.org/10.1258/la.2009.008122

APA

Fonseca, U. N. K., Nielsen, S. G., Hau, J., & Hansen, A. J. K. (2010). Permanent catheterization of the carotid artery induces kidney infection and inflammation in the rat. Laboratory Animals. Journal of the Laboratory Animal Science Association, 44(1), 46-53. https://doi.org/10.1258/la.2009.008122

Vancouver

Fonseca UNK, Nielsen SG, Hau J, Hansen AJK. Permanent catheterization of the carotid artery induces kidney infection and inflammation in the rat. Laboratory Animals. Journal of the Laboratory Animal Science Association. 2010;44(1):46-53. https://doi.org/10.1258/la.2009.008122

Author

Fonseca, Uno Nicolas Kjærup ; Nielsen, Sanne Gram ; Hau, Jann ; Hansen, Axel Jacob Kornerup. / Permanent catheterization of the carotid artery induces kidney infection and inflammation in the rat. I: Laboratory Animals. Journal of the Laboratory Animal Science Association. 2010 ; Bind 44, Nr. 1. s. 46-53.

Bibtex

@article{1e9fce7004dc11df825d000ea68e967b,
title = "Permanent catheterization of the carotid artery induces kidney infection and inflammation in the rat",
abstract = "Catheterization of the carotid artery and the jugular vein is one of the most commonly applied techniques used to gain intravascular access in pharmacology studies on rodents. We catheterized 10 rats by conventional clean techniques, 10 rats by aseptic techniques and 10 rats by conventional clean techniques using a heparin-coated catheter rather than an ordinary non-coated polyvinyl chloride catheter. In all groups, approximately 80% of the rats developed kidney infection and 10-30% of the rats were septicaemic. Clinical chemistry did not indicate severe kidney damage, but serum haptoglobin and body temperature rises indicated an inflammatory response in rats independent of the surgical method. Heparin coating did not seem to improve the usability of the catheter. It is concluded that this commonly used method for catheterization has an impact on animals that may very well render them unsuitable for the purpose, e.g. pharmacological research, and therefore an alternative method would be preferable.",
keywords = "Animals, Bacteremia, Body Temperature, Carotid Arteries, Catheterization, Peripheral, Catheters, Indwelling, Fever, Haptoglobins, Male, Nephritis, Rats, Rats, Sprague-Dawley",
author = "Fonseca, {Uno Nicolas Kj{\ae}rup} and Nielsen, {Sanne Gram} and Jann Hau and Hansen, {Axel Jacob Kornerup}",
year = "2010",
doi = "10.1258/la.2009.008122",
language = "English",
volume = "44",
pages = "46--53",
journal = "Laboratory Animals",
issn = "0023-6772",
publisher = "SAGE Publications",
number = "1",

}

RIS

TY - JOUR

T1 - Permanent catheterization of the carotid artery induces kidney infection and inflammation in the rat

AU - Fonseca, Uno Nicolas Kjærup

AU - Nielsen, Sanne Gram

AU - Hau, Jann

AU - Hansen, Axel Jacob Kornerup

PY - 2010

Y1 - 2010

N2 - Catheterization of the carotid artery and the jugular vein is one of the most commonly applied techniques used to gain intravascular access in pharmacology studies on rodents. We catheterized 10 rats by conventional clean techniques, 10 rats by aseptic techniques and 10 rats by conventional clean techniques using a heparin-coated catheter rather than an ordinary non-coated polyvinyl chloride catheter. In all groups, approximately 80% of the rats developed kidney infection and 10-30% of the rats were septicaemic. Clinical chemistry did not indicate severe kidney damage, but serum haptoglobin and body temperature rises indicated an inflammatory response in rats independent of the surgical method. Heparin coating did not seem to improve the usability of the catheter. It is concluded that this commonly used method for catheterization has an impact on animals that may very well render them unsuitable for the purpose, e.g. pharmacological research, and therefore an alternative method would be preferable.

AB - Catheterization of the carotid artery and the jugular vein is one of the most commonly applied techniques used to gain intravascular access in pharmacology studies on rodents. We catheterized 10 rats by conventional clean techniques, 10 rats by aseptic techniques and 10 rats by conventional clean techniques using a heparin-coated catheter rather than an ordinary non-coated polyvinyl chloride catheter. In all groups, approximately 80% of the rats developed kidney infection and 10-30% of the rats were septicaemic. Clinical chemistry did not indicate severe kidney damage, but serum haptoglobin and body temperature rises indicated an inflammatory response in rats independent of the surgical method. Heparin coating did not seem to improve the usability of the catheter. It is concluded that this commonly used method for catheterization has an impact on animals that may very well render them unsuitable for the purpose, e.g. pharmacological research, and therefore an alternative method would be preferable.

KW - Animals

KW - Bacteremia

KW - Body Temperature

KW - Carotid Arteries

KW - Catheterization, Peripheral

KW - Catheters, Indwelling

KW - Fever

KW - Haptoglobins

KW - Male

KW - Nephritis

KW - Rats

KW - Rats, Sprague-Dawley

U2 - 10.1258/la.2009.008122

DO - 10.1258/la.2009.008122

M3 - Journal article

C2 - 19858167

VL - 44

SP - 46

EP - 53

JO - Laboratory Animals

JF - Laboratory Animals

SN - 0023-6772

IS - 1

ER -

ID: 17083543