Plastic nanoparticles cause mild inflammation, disrupt metabolic pathways, change the gut microbiota and affect reproduction in zebrafish: A full generation multi-omics study
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Plastic pollution has become a major concern on a global scale. The plastic is broken down into minuscule particles, which have an impact on the biosystems, however long-term impacts through an entire generation is largely unknown. Here, we present the first whole generation study exposing fish to a 500 nm polystyrene plastic particle at environmentally relevant concentrations. Short- and long-term adverse effects were investigated in the zebrafish model organism using a holistic multi-omics approach. The particles accumulated in the yolk sac of young larvae and short-term biological impacts included immune-relevant gene regulation related to inflammation and tolerance as well as disruption of metabolic processes, such as the fatty acid and lipid pathways. The long-term effects comprised gene regulations pointing towards skin and/or gill inflammation, dysbiosis of the gut microbiota, a tendency towards decreased condition factor in adult males as well as a lowered reproductive capability. From this study, it can be concluded that exposures to plastic nanoparticles have an impact on population as well as ecosystem level in fish and likely also in other vertebrates.
| Originalsprog | Engelsk |
|---|---|
| Artikelnummer | 127705 |
| Tidsskrift | Journal of Hazardous Materials |
| Vol/bind | 424 |
| Udgave nummer | Part D |
| Antal sider | 16 |
| ISSN | 0304-3894 |
| DOI | |
| Status | Udgivet - 2022 |
Bibliografisk note
Funding Information:
We would like to thank Thorbj?rn Tonndorff for his help with the gene expression studies conducted at the University of Copenhagen. We also acknowledge the Carlsberg Foundation for the Research Infrastructure grants (CF20?0620, CF20?0422). Contribution to the construction of figures was kindly provided by Marek Marana. We would like to thank Dorthe Posselt, Roskilde University, for assistance with DLS measurements and engaging discussions of particle behavior in aquatic suspension. Acknowledgements also go to Stephen Renshaw, University of Sheffield, for the supply of transgenic zebrafish. We further acknowledge MarinePlastic, a Danish Centre for research in marine plastic pollution, sponsored by the Velux Foundation, grant number 25084. We also acknowledge funding from the financial starting grant from Aarhus University Research Foundation (AUFF-T- 2017-FLS-7?4), The Independent Research Fund Denmark (?HOSTgutINTERACT?, grant no. 9128?00003B), and ?the European Union's Horizon 2020 research and innovation program, under grant agreement No. 825753 (ERGO). This output reflects only the author's view, and the European Union cannot be held responsible for any use that may be made of the information contained therein.
Publisher Copyright:
© 2021 Elsevier B.V.
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