Porcine models of biofilm infections with focus on pathomorphology

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Standard

Porcine models of biofilm infections with focus on pathomorphology. / Jensen, Louise Kruse; Johansen, Anne Sofie Boyum; Jensen, Henrik Elvang.

I: Frontiers in Microbiology, Bind 8, 1961, 2017.

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Harvard

Jensen, LK, Johansen, ASB & Jensen, HE 2017, 'Porcine models of biofilm infections with focus on pathomorphology', Frontiers in Microbiology, bind 8, 1961. https://doi.org/10.3389/fmicb.2017.01961

APA

Jensen, L. K., Johansen, A. S. B., & Jensen, H. E. (2017). Porcine models of biofilm infections with focus on pathomorphology. Frontiers in Microbiology, 8, [1961]. https://doi.org/10.3389/fmicb.2017.01961

Vancouver

Jensen LK, Johansen ASB, Jensen HE. Porcine models of biofilm infections with focus on pathomorphology. Frontiers in Microbiology. 2017;8. 1961. https://doi.org/10.3389/fmicb.2017.01961

Author

Jensen, Louise Kruse ; Johansen, Anne Sofie Boyum ; Jensen, Henrik Elvang. / Porcine models of biofilm infections with focus on pathomorphology. I: Frontiers in Microbiology. 2017 ; Bind 8.

Bibtex

@article{89e3327b1ba44edca249b3cd345a0e88,
title = "Porcine models of biofilm infections with focus on pathomorphology",
abstract = "Bacterial biofilm formation is one of the main reasons for a negative treatment outcome and a high recurrence rate for many chronic infections in humans. The optimal way to study both the biofilm forming bacteria and the host response simultaneously is by using discriminative, reliable, and reproducible animal models of the infections. In this review, the advantages of in vivo studies are compared to in vitro studies of biofilm formation in infectious diseases. The pig is the animal of choice when developing and applying large animal models of infectious diseases due to its similarity of anatomy, physiology, and immune system to humans. Furthermore, conventional pigs spontaneously develop many of the same chronic bacterial infections as seen in humans. Therefore, in this review porcine models of five different infectious diseases all associated with biofilm formation and chronicity in humans are described. The infectious diseases are: chronic wounds, endocarditis, pyelonephritis, hematogenous osteomyelitis, and implant-associated osteomyelitis (IAO).",
author = "Jensen, {Louise Kruse} and Johansen, {Anne Sofie Boyum} and Jensen, {Henrik Elvang}",
year = "2017",
doi = "10.3389/fmicb.2017.01961",
language = "English",
volume = "8",
journal = "Frontiers in Microbiology",
issn = "1664-302X",
publisher = "Frontiers Media S.A.",

}

RIS

TY - JOUR

T1 - Porcine models of biofilm infections with focus on pathomorphology

AU - Jensen, Louise Kruse

AU - Johansen, Anne Sofie Boyum

AU - Jensen, Henrik Elvang

PY - 2017

Y1 - 2017

N2 - Bacterial biofilm formation is one of the main reasons for a negative treatment outcome and a high recurrence rate for many chronic infections in humans. The optimal way to study both the biofilm forming bacteria and the host response simultaneously is by using discriminative, reliable, and reproducible animal models of the infections. In this review, the advantages of in vivo studies are compared to in vitro studies of biofilm formation in infectious diseases. The pig is the animal of choice when developing and applying large animal models of infectious diseases due to its similarity of anatomy, physiology, and immune system to humans. Furthermore, conventional pigs spontaneously develop many of the same chronic bacterial infections as seen in humans. Therefore, in this review porcine models of five different infectious diseases all associated with biofilm formation and chronicity in humans are described. The infectious diseases are: chronic wounds, endocarditis, pyelonephritis, hematogenous osteomyelitis, and implant-associated osteomyelitis (IAO).

AB - Bacterial biofilm formation is one of the main reasons for a negative treatment outcome and a high recurrence rate for many chronic infections in humans. The optimal way to study both the biofilm forming bacteria and the host response simultaneously is by using discriminative, reliable, and reproducible animal models of the infections. In this review, the advantages of in vivo studies are compared to in vitro studies of biofilm formation in infectious diseases. The pig is the animal of choice when developing and applying large animal models of infectious diseases due to its similarity of anatomy, physiology, and immune system to humans. Furthermore, conventional pigs spontaneously develop many of the same chronic bacterial infections as seen in humans. Therefore, in this review porcine models of five different infectious diseases all associated with biofilm formation and chronicity in humans are described. The infectious diseases are: chronic wounds, endocarditis, pyelonephritis, hematogenous osteomyelitis, and implant-associated osteomyelitis (IAO).

U2 - 10.3389/fmicb.2017.01961

DO - 10.3389/fmicb.2017.01961

M3 - Review

C2 - 29067019

VL - 8

JO - Frontiers in Microbiology

JF - Frontiers in Microbiology

SN - 1664-302X

M1 - 1961

ER -

ID: 184320281