Postnatal Administration of Lactobacillus rhamnosus HN001 Ameliorates Perinatal Broad-Spectrum Antibiotic-Induced Reduction in Myelopoiesis and T Cell Activation in Mouse Pups

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Standard

Postnatal Administration of Lactobacillus rhamnosus HN001 Ameliorates Perinatal Broad-Spectrum Antibiotic-Induced Reduction in Myelopoiesis and T Cell Activation in Mouse Pups. / Fuglsang, Eva; Krych, Lukasz; Lundsager, Mia Thorup; Nielsen, Dennis Sandris; Frøkiær, Hanne.

I: Molecular Nutrition and Food Research, Bind 62, Nr. 22, 1800510, 11.2018, s. 1-12.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Fuglsang, E, Krych, L, Lundsager, MT, Nielsen, DS & Frøkiær, H 2018, 'Postnatal Administration of Lactobacillus rhamnosus HN001 Ameliorates Perinatal Broad-Spectrum Antibiotic-Induced Reduction in Myelopoiesis and T Cell Activation in Mouse Pups', Molecular Nutrition and Food Research, bind 62, nr. 22, 1800510, s. 1-12. https://doi.org/10.1002/mnfr.201800510

APA

Fuglsang, E., Krych, L., Lundsager, M. T., Nielsen, D. S., & Frøkiær, H. (2018). Postnatal Administration of Lactobacillus rhamnosus HN001 Ameliorates Perinatal Broad-Spectrum Antibiotic-Induced Reduction in Myelopoiesis and T Cell Activation in Mouse Pups. Molecular Nutrition and Food Research, 62(22), 1-12. [1800510]. https://doi.org/10.1002/mnfr.201800510

Vancouver

Fuglsang E, Krych L, Lundsager MT, Nielsen DS, Frøkiær H. Postnatal Administration of Lactobacillus rhamnosus HN001 Ameliorates Perinatal Broad-Spectrum Antibiotic-Induced Reduction in Myelopoiesis and T Cell Activation in Mouse Pups. Molecular Nutrition and Food Research. 2018 nov.;62(22):1-12. 1800510. https://doi.org/10.1002/mnfr.201800510

Author

Fuglsang, Eva ; Krych, Lukasz ; Lundsager, Mia Thorup ; Nielsen, Dennis Sandris ; Frøkiær, Hanne. / Postnatal Administration of Lactobacillus rhamnosus HN001 Ameliorates Perinatal Broad-Spectrum Antibiotic-Induced Reduction in Myelopoiesis and T Cell Activation in Mouse Pups. I: Molecular Nutrition and Food Research. 2018 ; Bind 62, Nr. 22. s. 1-12.

Bibtex

@article{df95939054174bfab94ad16c7c33dbc0,
title = "Postnatal Administration of Lactobacillus rhamnosus HN001 Ameliorates Perinatal Broad-Spectrum Antibiotic-Induced Reduction in Myelopoiesis and T Cell Activation in Mouse Pups",
abstract = "Scope: This study addresses whether administration of Lactobacillus rhamnosus HN001 could mitigate the effects of a compromised gut microbiota on the composition of mature leukocytes and granulocyte-macrophage progenitor cells (GMPs) in newborn mice. Methods and results: Pregnant dams receive oral broad-spectrum antibiotics, which dramatically decrease the gut microbial composition analyzed by 16S rRNA sequencing. Perinatal antibiotic treatment decreases the proportions of bone marrow (BM) GMPs (postnatal day (PND2): 0.5% vs 0.8%, PND4: 0.2% to 0.6%) and mature granulocytes (33% vs 24% at PND2), and spleen granulocytes (7% vs 17% at PND2) and B cells (PND2:18% vs 28%, PND4:11% vs 22%). At PND35, T helper (Th) cells (20% vs 14%) and cytotoxic T (Tc) cells (10% vs 8%) decrease in the spleen. Oral administration of L. rhamnosus HN001 to neonatal pups (PND1-7) restores the antibiotic-induced changes of GMPs and granulocytes in BM and spleen, and further increases splenic granulocytes in control pups. At PND35, splenic proportions of B and Th but not Tc cells are restored. Conclusion: Postnatal administration of a single bacterial strain efficiently restores granulopoiesis and most T cell activation in neonatal mice that suffer from a perinatal antibiotic-induced compromised gut microbiota at birth.",
keywords = "antibiotics, granulopoiesis, gut microbiota, Lactobacillus rhamnosus, T cells",
author = "Eva Fuglsang and Lukasz Krych and Lundsager, {Mia Thorup} and Nielsen, {Dennis Sandris} and Hanne Fr{\o}ki{\ae}r",
year = "2018",
month = nov,
doi = "10.1002/mnfr.201800510",
language = "English",
volume = "62",
pages = "1--12",
journal = "Molecular Nutrition & Food Research",
issn = "1613-4125",
publisher = "Wiley-VCH",
number = "22",

}

RIS

TY - JOUR

T1 - Postnatal Administration of Lactobacillus rhamnosus HN001 Ameliorates Perinatal Broad-Spectrum Antibiotic-Induced Reduction in Myelopoiesis and T Cell Activation in Mouse Pups

AU - Fuglsang, Eva

AU - Krych, Lukasz

AU - Lundsager, Mia Thorup

AU - Nielsen, Dennis Sandris

AU - Frøkiær, Hanne

PY - 2018/11

Y1 - 2018/11

N2 - Scope: This study addresses whether administration of Lactobacillus rhamnosus HN001 could mitigate the effects of a compromised gut microbiota on the composition of mature leukocytes and granulocyte-macrophage progenitor cells (GMPs) in newborn mice. Methods and results: Pregnant dams receive oral broad-spectrum antibiotics, which dramatically decrease the gut microbial composition analyzed by 16S rRNA sequencing. Perinatal antibiotic treatment decreases the proportions of bone marrow (BM) GMPs (postnatal day (PND2): 0.5% vs 0.8%, PND4: 0.2% to 0.6%) and mature granulocytes (33% vs 24% at PND2), and spleen granulocytes (7% vs 17% at PND2) and B cells (PND2:18% vs 28%, PND4:11% vs 22%). At PND35, T helper (Th) cells (20% vs 14%) and cytotoxic T (Tc) cells (10% vs 8%) decrease in the spleen. Oral administration of L. rhamnosus HN001 to neonatal pups (PND1-7) restores the antibiotic-induced changes of GMPs and granulocytes in BM and spleen, and further increases splenic granulocytes in control pups. At PND35, splenic proportions of B and Th but not Tc cells are restored. Conclusion: Postnatal administration of a single bacterial strain efficiently restores granulopoiesis and most T cell activation in neonatal mice that suffer from a perinatal antibiotic-induced compromised gut microbiota at birth.

AB - Scope: This study addresses whether administration of Lactobacillus rhamnosus HN001 could mitigate the effects of a compromised gut microbiota on the composition of mature leukocytes and granulocyte-macrophage progenitor cells (GMPs) in newborn mice. Methods and results: Pregnant dams receive oral broad-spectrum antibiotics, which dramatically decrease the gut microbial composition analyzed by 16S rRNA sequencing. Perinatal antibiotic treatment decreases the proportions of bone marrow (BM) GMPs (postnatal day (PND2): 0.5% vs 0.8%, PND4: 0.2% to 0.6%) and mature granulocytes (33% vs 24% at PND2), and spleen granulocytes (7% vs 17% at PND2) and B cells (PND2:18% vs 28%, PND4:11% vs 22%). At PND35, T helper (Th) cells (20% vs 14%) and cytotoxic T (Tc) cells (10% vs 8%) decrease in the spleen. Oral administration of L. rhamnosus HN001 to neonatal pups (PND1-7) restores the antibiotic-induced changes of GMPs and granulocytes in BM and spleen, and further increases splenic granulocytes in control pups. At PND35, splenic proportions of B and Th but not Tc cells are restored. Conclusion: Postnatal administration of a single bacterial strain efficiently restores granulopoiesis and most T cell activation in neonatal mice that suffer from a perinatal antibiotic-induced compromised gut microbiota at birth.

KW - antibiotics

KW - granulopoiesis

KW - gut microbiota

KW - Lactobacillus rhamnosus

KW - T cells

U2 - 10.1002/mnfr.201800510

DO - 10.1002/mnfr.201800510

M3 - Journal article

C2 - 30211987

AN - SCOPUS:85054475828

VL - 62

SP - 1

EP - 12

JO - Molecular Nutrition & Food Research

JF - Molecular Nutrition & Food Research

SN - 1613-4125

IS - 22

M1 - 1800510

ER -

ID: 208978511