Prognostic role of syncytin expression in breast cancer

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Standard

Prognostic role of syncytin expression in breast cancer. / Larsson, Lars-Inge; Holck, Susanne; Christensen, Ib Jarle.

I: Human Pathology, Bind 38, Nr. 5, 2007, s. 726-731.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Larsson, L-I, Holck, S & Christensen, IJ 2007, 'Prognostic role of syncytin expression in breast cancer', Human Pathology, bind 38, nr. 5, s. 726-731. https://doi.org/10.1016/j.humpath.2006.10.018

APA

Larsson, L-I., Holck, S., & Christensen, I. J. (2007). Prognostic role of syncytin expression in breast cancer. Human Pathology, 38(5), 726-731. https://doi.org/10.1016/j.humpath.2006.10.018

Vancouver

Larsson L-I, Holck S, Christensen IJ. Prognostic role of syncytin expression in breast cancer. Human Pathology. 2007;38(5):726-731. https://doi.org/10.1016/j.humpath.2006.10.018

Author

Larsson, Lars-Inge ; Holck, Susanne ; Christensen, Ib Jarle. / Prognostic role of syncytin expression in breast cancer. I: Human Pathology. 2007 ; Bind 38, Nr. 5. s. 726-731.

Bibtex

@article{5d11adf0a1c211ddb6ae000ea68e967b,
title = "Prognostic role of syncytin expression in breast cancer",
abstract = "Breast cancer cells were recently found to produce syncytin, an endogenous retroviral protein implicated in cell fusion, immune regulation, and nitric oxide synthase expression. To determine whether syncytin has a prognostic role in breast cancer, we investigated a series of 165 premenopausal lymph node-negative women for syncytin expression using an immunocytochemical scoring system. Results were analyzed with the Kaplan-Meier method and with the Cox proportional hazard model. Syncytin expression was observed in 38% of the patients, and the degree of syncytin expression constituted a positive prognostic indicator for recurrence-free survival. In addition, we examined a second series of 54 consecutively operated breast cancer patients of all categories and the results supported the conclusions made from the first study. Thus, syncytin expression constitutes a positive prognostic factor in breast cancer - a phenomenon that may be related to the involvement of syncytin in mediating fusions between breast cancer cells and entodhelial cells.",
keywords = "Former LIFE faculty, Syncytin, Retroviral envelope protein, Breast cancer, Immunocytochemistry, Prognosis",
author = "Lars-Inge Larsson and Susanne Holck and Christensen, {Ib Jarle}",
year = "2007",
doi = "10.1016/j.humpath.2006.10.018",
language = "English",
volume = "38",
pages = "726--731",
journal = "Human Pathology",
issn = "0046-8177",
publisher = "W.B.Saunders Co.",
number = "5",

}

RIS

TY - JOUR

T1 - Prognostic role of syncytin expression in breast cancer

AU - Larsson, Lars-Inge

AU - Holck, Susanne

AU - Christensen, Ib Jarle

PY - 2007

Y1 - 2007

N2 - Breast cancer cells were recently found to produce syncytin, an endogenous retroviral protein implicated in cell fusion, immune regulation, and nitric oxide synthase expression. To determine whether syncytin has a prognostic role in breast cancer, we investigated a series of 165 premenopausal lymph node-negative women for syncytin expression using an immunocytochemical scoring system. Results were analyzed with the Kaplan-Meier method and with the Cox proportional hazard model. Syncytin expression was observed in 38% of the patients, and the degree of syncytin expression constituted a positive prognostic indicator for recurrence-free survival. In addition, we examined a second series of 54 consecutively operated breast cancer patients of all categories and the results supported the conclusions made from the first study. Thus, syncytin expression constitutes a positive prognostic factor in breast cancer - a phenomenon that may be related to the involvement of syncytin in mediating fusions between breast cancer cells and entodhelial cells.

AB - Breast cancer cells were recently found to produce syncytin, an endogenous retroviral protein implicated in cell fusion, immune regulation, and nitric oxide synthase expression. To determine whether syncytin has a prognostic role in breast cancer, we investigated a series of 165 premenopausal lymph node-negative women for syncytin expression using an immunocytochemical scoring system. Results were analyzed with the Kaplan-Meier method and with the Cox proportional hazard model. Syncytin expression was observed in 38% of the patients, and the degree of syncytin expression constituted a positive prognostic indicator for recurrence-free survival. In addition, we examined a second series of 54 consecutively operated breast cancer patients of all categories and the results supported the conclusions made from the first study. Thus, syncytin expression constitutes a positive prognostic factor in breast cancer - a phenomenon that may be related to the involvement of syncytin in mediating fusions between breast cancer cells and entodhelial cells.

KW - Former LIFE faculty

KW - Syncytin

KW - Retroviral envelope protein

KW - Breast cancer

KW - Immunocytochemistry

KW - Prognosis

U2 - 10.1016/j.humpath.2006.10.018

DO - 10.1016/j.humpath.2006.10.018

M3 - Journal article

C2 - 17306327

VL - 38

SP - 726

EP - 731

JO - Human Pathology

JF - Human Pathology

SN - 0046-8177

IS - 5

ER -

ID: 8069272