Quality Assessment of Domesticated Animal Genome Assemblies

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Standard

Quality Assessment of Domesticated Animal Genome Assemblies. / Seemann, Stefan E; Anthon, Christian; Palasca, Oana; Gorodkin, Jan.

I: Bioinformatics and Biology Insights, Bind 9, Nr. Suppl 4, 2015, s. 49-58.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Seemann, SE, Anthon, C, Palasca, O & Gorodkin, J 2015, 'Quality Assessment of Domesticated Animal Genome Assemblies', Bioinformatics and Biology Insights, bind 9, nr. Suppl 4, s. 49-58. https://doi.org/10.4137/BBI.S29333

APA

Seemann, S. E., Anthon, C., Palasca, O., & Gorodkin, J. (2015). Quality Assessment of Domesticated Animal Genome Assemblies. Bioinformatics and Biology Insights, 9(Suppl 4), 49-58. https://doi.org/10.4137/BBI.S29333

Vancouver

Seemann SE, Anthon C, Palasca O, Gorodkin J. Quality Assessment of Domesticated Animal Genome Assemblies. Bioinformatics and Biology Insights. 2015;9(Suppl 4):49-58. https://doi.org/10.4137/BBI.S29333

Author

Seemann, Stefan E ; Anthon, Christian ; Palasca, Oana ; Gorodkin, Jan. / Quality Assessment of Domesticated Animal Genome Assemblies. I: Bioinformatics and Biology Insights. 2015 ; Bind 9, Nr. Suppl 4. s. 49-58.

Bibtex

@article{9076a151e2124d3eb6692c388757b0b3,
title = "Quality Assessment of Domesticated Animal Genome Assemblies",
abstract = "The era of high-throughput sequencing has made it relatively simple to sequence genomes and transcriptomes of individuals from many species. In order to analyze the resulting sequencing data, high-quality reference genome assemblies are required. However, this is still a major challenge, and many domesticated animal genomes still need to be sequenced deeper in order to produce high-quality assemblies. In the meanwhile, ironically, the extent to which RNAseq and other next-generation data is produced frequently far exceeds that of the genomic sequence. Furthermore, basic comparative analysis is often affected by the lack of genomic sequence. Herein, we quantify the quality of the genome assemblies of 20 domesticated animals and related species by assessing a range of measurable parameters, and we show that there is a positive correlation between the fraction of mappable reads from RNAseq data and genome assembly quality. We rank the genomes by their assembly quality and discuss the implications for genotype analyses.",
author = "Seemann, {Stefan E} and Christian Anthon and Oana Palasca and Jan Gorodkin",
year = "2015",
doi = "10.4137/BBI.S29333",
language = "English",
volume = "9",
pages = "49--58",
journal = "Bioinformatics and Biology Insights",
issn = "1177-9322",
publisher = "Libertas Academica Ltd.",
number = "Suppl 4",

}

RIS

TY - JOUR

T1 - Quality Assessment of Domesticated Animal Genome Assemblies

AU - Seemann, Stefan E

AU - Anthon, Christian

AU - Palasca, Oana

AU - Gorodkin, Jan

PY - 2015

Y1 - 2015

N2 - The era of high-throughput sequencing has made it relatively simple to sequence genomes and transcriptomes of individuals from many species. In order to analyze the resulting sequencing data, high-quality reference genome assemblies are required. However, this is still a major challenge, and many domesticated animal genomes still need to be sequenced deeper in order to produce high-quality assemblies. In the meanwhile, ironically, the extent to which RNAseq and other next-generation data is produced frequently far exceeds that of the genomic sequence. Furthermore, basic comparative analysis is often affected by the lack of genomic sequence. Herein, we quantify the quality of the genome assemblies of 20 domesticated animals and related species by assessing a range of measurable parameters, and we show that there is a positive correlation between the fraction of mappable reads from RNAseq data and genome assembly quality. We rank the genomes by their assembly quality and discuss the implications for genotype analyses.

AB - The era of high-throughput sequencing has made it relatively simple to sequence genomes and transcriptomes of individuals from many species. In order to analyze the resulting sequencing data, high-quality reference genome assemblies are required. However, this is still a major challenge, and many domesticated animal genomes still need to be sequenced deeper in order to produce high-quality assemblies. In the meanwhile, ironically, the extent to which RNAseq and other next-generation data is produced frequently far exceeds that of the genomic sequence. Furthermore, basic comparative analysis is often affected by the lack of genomic sequence. Herein, we quantify the quality of the genome assemblies of 20 domesticated animals and related species by assessing a range of measurable parameters, and we show that there is a positive correlation between the fraction of mappable reads from RNAseq data and genome assembly quality. We rank the genomes by their assembly quality and discuss the implications for genotype analyses.

U2 - 10.4137/BBI.S29333

DO - 10.4137/BBI.S29333

M3 - Journal article

C2 - 27279738

VL - 9

SP - 49

EP - 58

JO - Bioinformatics and Biology Insights

JF - Bioinformatics and Biology Insights

SN - 1177-9322

IS - Suppl 4

ER -

ID: 172395945