Renal enzyme activities in experimental ochratoxin a-induced porcine nephropathy: Diagnostic potential of phosphoenolpyruvate carboxyk1nase and gamma-glutamyl transpeptidase activity
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Renal enzyme activities in experimental ochratoxin a-induced porcine nephropathy : Diagnostic potential of phosphoenolpyruvate carboxyk1nase and gamma-glutamyl transpeptidase activity. / Krogh, Palle; Gyrd-Hansen, Nils; Hatd, Benedicte; Larsen, Steen; Nielsen, Jens Peter; Smith, Mogens; Ivanoff, Chris; Meisner, Herman.
I: Journal of Toxicology and Environmental Health, Bind 23, Nr. 1, 01.1988, s. 1-14.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Renal enzyme activities in experimental ochratoxin a-induced porcine nephropathy
T2 - Diagnostic potential of phosphoenolpyruvate carboxyk1nase and gamma-glutamyl transpeptidase activity
AU - Krogh, Palle
AU - Gyrd-Hansen, Nils
AU - Hatd, Benedicte
AU - Larsen, Steen
AU - Nielsen, Jens Peter
AU - Smith, Mogens
AU - Ivanoff, Chris
AU - Meisner, Herman
N1 - Funding Information: This researchwas supported in part by National Institutes of Health grant AM 27987.We wish thank Helge Cydesen for assistance in the statistical analysis. Requests for reprints should be sent to Palle Krogh, Department of Microbiology, Royal Den-College, Juliane Mariesvej 30, DK-2100 Copenhagen, Denmark.
PY - 1988/1
Y1 - 1988/1
N2 - Enzyme activities have been measured in needle biopsies from kidneys of pigs fed 1 ppm or 0.2 ppm of ochratoxin A for 1-5 wks. After feeding 1 ppm toxin for 1 wk, the activity of cytosolic phosphoenolpyruvate carboxykinase (PEPCK) was decreased by 40% and remained inhibited until the termination of the experiment (5 wk). The activity of gamma-glutamyl transpeptidase, a brush-border enzyme found in the proximal tubules, was reduced to a similar degree and remained inhibited. The activities of hexokinase, a cytosolic enzyme of general distribution in the nephron, and phosphate-dependent.
AB - Enzyme activities have been measured in needle biopsies from kidneys of pigs fed 1 ppm or 0.2 ppm of ochratoxin A for 1-5 wks. After feeding 1 ppm toxin for 1 wk, the activity of cytosolic phosphoenolpyruvate carboxykinase (PEPCK) was decreased by 40% and remained inhibited until the termination of the experiment (5 wk). The activity of gamma-glutamyl transpeptidase, a brush-border enzyme found in the proximal tubules, was reduced to a similar degree and remained inhibited. The activities of hexokinase, a cytosolic enzyme of general distribution in the nephron, and phosphate-dependent.
UR - http://www.scopus.com/inward/record.url?scp=0023852753&partnerID=8YFLogxK
U2 - 10.1080/15287398809531092
DO - 10.1080/15287398809531092
M3 - Journal article
C2 - 2891856
AN - SCOPUS:0023852753
VL - 23
SP - 1
EP - 14
JO - Journal of Toxicology and Environmental Health
JF - Journal of Toxicology and Environmental Health
SN - 0098-4108
IS - 1
ER -
ID: 285717528