Safety and efficacy of a feed additive consisting of endo-1,4-β-xylanase produced by Komagataella phaffii ATCC PTA-127053 (Xygest™ HT) for poultry (Kemin Europa N.V.)
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Safety and efficacy of a feed additive consisting of endo-1,4-β-xylanase produced by Komagataella phaffii ATCC PTA-127053 (Xygest™ HT) for poultry (Kemin Europa N.V.). / EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP).
I: EFSA Journal, Bind 20, Nr. 7, e07439, 2022.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning
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TY - JOUR
T1 - Safety and efficacy of a feed additive consisting of endo-1,4-β-xylanase produced by Komagataella phaffii ATCC PTA-127053 (Xygest™ HT) for poultry (Kemin Europa N.V.)
AU - Bampidis, Vasileios
AU - Azimonti, Giovanna
AU - Bastos, Maria de Lourdes
AU - Christensen, Henrik
AU - Dusemund, Birgit
AU - Fašmon Durjava, Mojca
AU - Kouba, Maryline
AU - López-Alonso, Marta
AU - López Puente, Secundino
AU - Marcon, Francesca
AU - Mayo, Baltasar
AU - Pechová, Alena
AU - Petkova, Mariana
AU - Ramos, Fernando
AU - Sanz, Yolanda
AU - Villa, Roberto Edoardo
AU - Woutersen, Ruud
AU - Glandorf, Boet
AU - Brantom, Paul
AU - Anguita, Montserrat
AU - Galobart, Jaume
AU - Manini, Paola
AU - Ortuño, Jordi
AU - Pettenati, Elisa
AU - Pizzo, Fabiola
AU - Tarrés, Jordi
AU - Revez, Joana
AU - EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)
N1 - Publisher Copyright: © 2022 Wiley-VCH Verlag GmbH & Co. KgaA on behalf of the European Food Safety Authority.
PY - 2022
Y1 - 2022
N2 - Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of endo-1,4-β-xylanase produced by Komagataella phaffii ATCC PTA-127053 (Xygest™ HT) as a zootechnical feed additive for poultry. The production strain is genetically modified. No viable cells nor recombinant DNA of the production strain were detected in the final product. Therefore, the Panel concluded that the additive does not pose any safety concern regarding the production strain. The FEEDAP Panel concluded that Xygest™ HT is considered safe for chickens for fattening at 30,000 U/kg and in laying hens at 45,000 U/kg, with a wide margin of safety. These conclusions can be extended to chickens reared for laying/breeding and extrapolated to all poultry species for fattening and reared for laying/breeding and to ornamental birds. The conclusions on laying hens are extrapolated to all laying poultry species. The use of Xygest™ HT in animal nutrition is of no concern for consumer safety and this feed additive is considered safe for the environment. The Panel also concluded that Xygest™ HT is not irritant to the eyes and skin but should be considered a dermal and a respiratory sensitiser. The Panel concluded that the additive Xygest™ HT has a potential to be efficacious for laying hens under the proposed conditions of use and this conclusion can also be extrapolated to all laying poultry species. The Panel could not conclude on the efficacy of the product for chickens for fattening due to insufficient data.
AB - Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of endo-1,4-β-xylanase produced by Komagataella phaffii ATCC PTA-127053 (Xygest™ HT) as a zootechnical feed additive for poultry. The production strain is genetically modified. No viable cells nor recombinant DNA of the production strain were detected in the final product. Therefore, the Panel concluded that the additive does not pose any safety concern regarding the production strain. The FEEDAP Panel concluded that Xygest™ HT is considered safe for chickens for fattening at 30,000 U/kg and in laying hens at 45,000 U/kg, with a wide margin of safety. These conclusions can be extended to chickens reared for laying/breeding and extrapolated to all poultry species for fattening and reared for laying/breeding and to ornamental birds. The conclusions on laying hens are extrapolated to all laying poultry species. The use of Xygest™ HT in animal nutrition is of no concern for consumer safety and this feed additive is considered safe for the environment. The Panel also concluded that Xygest™ HT is not irritant to the eyes and skin but should be considered a dermal and a respiratory sensitiser. The Panel concluded that the additive Xygest™ HT has a potential to be efficacious for laying hens under the proposed conditions of use and this conclusion can also be extrapolated to all laying poultry species. The Panel could not conclude on the efficacy of the product for chickens for fattening due to insufficient data.
KW - digestibility enhancers
KW - efficacy
KW - endo-1,4-β-xylanase
KW - poultry
KW - safety
KW - Xygest™ HT
KW - zootechnical additives
U2 - 10.2903/j.efsa.2022.7439
DO - 10.2903/j.efsa.2022.7439
M3 - Journal article
C2 - 35873724
AN - SCOPUS:85135175443
VL - 20
JO - E F S A Journal
JF - E F S A Journal
SN - 1831-4732
IS - 7
M1 - e07439
ER -
ID: 320356772