Safety and efficacy of concentrated liquid l-lysine (base) and l-lysine monohydrochloride produced by fermentation with Corynebacterium casei KCCM 80190 as feed additives for all animal species

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning

Standard

Safety and efficacy of concentrated liquid l-lysine (base) and l-lysine monohydrochloride produced by fermentation with Corynebacterium casei KCCM 80190 as feed additives for all animal species. / Bampidis, Vasileios; Azimonti, Giovanna; Bastos, Maria de Lourdes; Christensen, Henrik; Dusemund, Birgit; Kouba, Maryline; Durjava, Mojca Fašmon; López-Alonso, Marta; López Puente, Secundino; Marcon, Francesca; Mayo, Baltasar; Pechová, Alena; Petkova, Mariana; Ramos, Fernando; Sanz, Yolanda; Villa, Roberto Edoardo; Woutersen, Ruud; Cocconcelli, Pier Sandro; Glandorf, Boet; Herman, Lieve; Maradona, Miguel Prieto; Saarela, Maria; Anguita, Montserrat; Galobart, Jaume; Holczkencht, Orsolya; Manini, Paola; Pettenati, Elisa; Pizzo, Fabiola; Tarrés-Call, Jordi; EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP).

I: EFSA Journal, Bind 18, Nr. 11, e06285, 2020.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning

Harvard

Bampidis, V, Azimonti, G, Bastos, MDL, Christensen, H, Dusemund, B, Kouba, M, Durjava, MF, López-Alonso, M, López Puente, S, Marcon, F, Mayo, B, Pechová, A, Petkova, M, Ramos, F, Sanz, Y, Villa, RE, Woutersen, R, Cocconcelli, PS, Glandorf, B, Herman, L, Maradona, MP, Saarela, M, Anguita, M, Galobart, J, Holczkencht, O, Manini, P, Pettenati, E, Pizzo, F, Tarrés-Call, J & EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) 2020, 'Safety and efficacy of concentrated liquid l-lysine (base) and l-lysine monohydrochloride produced by fermentation with Corynebacterium casei KCCM 80190 as feed additives for all animal species', EFSA Journal, bind 18, nr. 11, e06285. https://doi.org/10.2903/j.efsa.2020.6285

APA

Bampidis, V., Azimonti, G., Bastos, M. D. L., Christensen, H., Dusemund, B., Kouba, M., Durjava, M. F., López-Alonso, M., López Puente, S., Marcon, F., Mayo, B., Pechová, A., Petkova, M., Ramos, F., Sanz, Y., Villa, R. E., Woutersen, R., Cocconcelli, P. S., Glandorf, B., ... EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) (2020). Safety and efficacy of concentrated liquid l-lysine (base) and l-lysine monohydrochloride produced by fermentation with Corynebacterium casei KCCM 80190 as feed additives for all animal species. EFSA Journal, 18(11), [e06285]. https://doi.org/10.2903/j.efsa.2020.6285

Vancouver

Bampidis V, Azimonti G, Bastos MDL, Christensen H, Dusemund B, Kouba M o.a. Safety and efficacy of concentrated liquid l-lysine (base) and l-lysine monohydrochloride produced by fermentation with Corynebacterium casei KCCM 80190 as feed additives for all animal species. EFSA Journal. 2020;18(11). e06285. https://doi.org/10.2903/j.efsa.2020.6285

Author

Bampidis, Vasileios ; Azimonti, Giovanna ; Bastos, Maria de Lourdes ; Christensen, Henrik ; Dusemund, Birgit ; Kouba, Maryline ; Durjava, Mojca Fašmon ; López-Alonso, Marta ; López Puente, Secundino ; Marcon, Francesca ; Mayo, Baltasar ; Pechová, Alena ; Petkova, Mariana ; Ramos, Fernando ; Sanz, Yolanda ; Villa, Roberto Edoardo ; Woutersen, Ruud ; Cocconcelli, Pier Sandro ; Glandorf, Boet ; Herman, Lieve ; Maradona, Miguel Prieto ; Saarela, Maria ; Anguita, Montserrat ; Galobart, Jaume ; Holczkencht, Orsolya ; Manini, Paola ; Pettenati, Elisa ; Pizzo, Fabiola ; Tarrés-Call, Jordi ; EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP). / Safety and efficacy of concentrated liquid l-lysine (base) and l-lysine monohydrochloride produced by fermentation with Corynebacterium casei KCCM 80190 as feed additives for all animal species. I: EFSA Journal. 2020 ; Bind 18, Nr. 11.

Bibtex

@article{03be420985a242efb76a4354ff516e31,
title = "Safety and efficacy of concentrated liquid l-lysine (base) and l-lysine monohydrochloride produced by fermentation with Corynebacterium casei KCCM 80190 as feed additives for all animal species",
abstract = "Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on concentrated liquid l-lysine (base) and l-lysine monohydrochloride (HCl) produced using Corynebacterium caseiKCCM 80190 when used as nutritional additives in feed and water for drinking for all animal species. The active substance is l-lysine. The production strain is genetically modified. It does not carry acquired antimicrobial resistance genes and no viable cells of the production strain nor its DNA were detected in the final products. Therefore, the additives do not pose any safety concern regarding the genetic modifications. Concentrated liquid l-lysine (base) and l-lysine HCl produced by C. caseiKCCM 80190 do not represent a risk for the target species, the consumer and the environment. From the results of studies on the safety for the user of concentrated liquid l-lysine (base) and l-lysine HCl produced by a different production strain, it was possible to conclude on the safety for the user of the products under assessment. Concentrated liquid l-lysine (base) produced by C. caseiKCCM 80190 is considered hazardous by inhalation, not irritant to skin and eyes and it is not a skin sensitiser. l-Lysine HCl produced by C. caseiKCCM 80190 is considered hazardous by inhalation, it is not irritant to skin but mildly irritant to eyes and it is not a skin sensitiser. Concentrated liquid l-lysine (base) and l-lysine HCl are considered efficacious sources of the essential amino acid l-lysine for non-ruminant animal species. For the supplemental l-lysine to be as efficacious in ruminants as in non-ruminant species, it would require protection against degradation in the rumen.",
keywords = "concentrated liquid l-lysine (base), Corynebacterium casei, efficacy, lysine monohydrochloride, nutritional additive, Safety, their salts and analogues{\textquoteright}, {\textquoteleft}amino acids",
author = "Vasileios Bampidis and Giovanna Azimonti and Bastos, {Maria de Lourdes} and Henrik Christensen and Birgit Dusemund and Maryline Kouba and Durjava, {Mojca Fa{\v s}mon} and Marta L{\'o}pez-Alonso and {L{\'o}pez Puente}, Secundino and Francesca Marcon and Baltasar Mayo and Alena Pechov{\'a} and Mariana Petkova and Fernando Ramos and Yolanda Sanz and Villa, {Roberto Edoardo} and Ruud Woutersen and Cocconcelli, {Pier Sandro} and Boet Glandorf and Lieve Herman and Maradona, {Miguel Prieto} and Maria Saarela and Montserrat Anguita and Jaume Galobart and Orsolya Holczkencht and Paola Manini and Elisa Pettenati and Fabiola Pizzo and Jordi Tarr{\'e}s-Call and {EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)}",
year = "2020",
doi = "10.2903/j.efsa.2020.6285",
language = "English",
volume = "18",
journal = "E F S A Journal",
issn = "1831-4732",
publisher = "European Food Safety Authority (E F S A)",
number = "11",

}

RIS

TY - JOUR

T1 - Safety and efficacy of concentrated liquid l-lysine (base) and l-lysine monohydrochloride produced by fermentation with Corynebacterium casei KCCM 80190 as feed additives for all animal species

AU - Bampidis, Vasileios

AU - Azimonti, Giovanna

AU - Bastos, Maria de Lourdes

AU - Christensen, Henrik

AU - Dusemund, Birgit

AU - Kouba, Maryline

AU - Durjava, Mojca Fašmon

AU - López-Alonso, Marta

AU - López Puente, Secundino

AU - Marcon, Francesca

AU - Mayo, Baltasar

AU - Pechová, Alena

AU - Petkova, Mariana

AU - Ramos, Fernando

AU - Sanz, Yolanda

AU - Villa, Roberto Edoardo

AU - Woutersen, Ruud

AU - Cocconcelli, Pier Sandro

AU - Glandorf, Boet

AU - Herman, Lieve

AU - Maradona, Miguel Prieto

AU - Saarela, Maria

AU - Anguita, Montserrat

AU - Galobart, Jaume

AU - Holczkencht, Orsolya

AU - Manini, Paola

AU - Pettenati, Elisa

AU - Pizzo, Fabiola

AU - Tarrés-Call, Jordi

AU - EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)

PY - 2020

Y1 - 2020

N2 - Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on concentrated liquid l-lysine (base) and l-lysine monohydrochloride (HCl) produced using Corynebacterium caseiKCCM 80190 when used as nutritional additives in feed and water for drinking for all animal species. The active substance is l-lysine. The production strain is genetically modified. It does not carry acquired antimicrobial resistance genes and no viable cells of the production strain nor its DNA were detected in the final products. Therefore, the additives do not pose any safety concern regarding the genetic modifications. Concentrated liquid l-lysine (base) and l-lysine HCl produced by C. caseiKCCM 80190 do not represent a risk for the target species, the consumer and the environment. From the results of studies on the safety for the user of concentrated liquid l-lysine (base) and l-lysine HCl produced by a different production strain, it was possible to conclude on the safety for the user of the products under assessment. Concentrated liquid l-lysine (base) produced by C. caseiKCCM 80190 is considered hazardous by inhalation, not irritant to skin and eyes and it is not a skin sensitiser. l-Lysine HCl produced by C. caseiKCCM 80190 is considered hazardous by inhalation, it is not irritant to skin but mildly irritant to eyes and it is not a skin sensitiser. Concentrated liquid l-lysine (base) and l-lysine HCl are considered efficacious sources of the essential amino acid l-lysine for non-ruminant animal species. For the supplemental l-lysine to be as efficacious in ruminants as in non-ruminant species, it would require protection against degradation in the rumen.

AB - Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on concentrated liquid l-lysine (base) and l-lysine monohydrochloride (HCl) produced using Corynebacterium caseiKCCM 80190 when used as nutritional additives in feed and water for drinking for all animal species. The active substance is l-lysine. The production strain is genetically modified. It does not carry acquired antimicrobial resistance genes and no viable cells of the production strain nor its DNA were detected in the final products. Therefore, the additives do not pose any safety concern regarding the genetic modifications. Concentrated liquid l-lysine (base) and l-lysine HCl produced by C. caseiKCCM 80190 do not represent a risk for the target species, the consumer and the environment. From the results of studies on the safety for the user of concentrated liquid l-lysine (base) and l-lysine HCl produced by a different production strain, it was possible to conclude on the safety for the user of the products under assessment. Concentrated liquid l-lysine (base) produced by C. caseiKCCM 80190 is considered hazardous by inhalation, not irritant to skin and eyes and it is not a skin sensitiser. l-Lysine HCl produced by C. caseiKCCM 80190 is considered hazardous by inhalation, it is not irritant to skin but mildly irritant to eyes and it is not a skin sensitiser. Concentrated liquid l-lysine (base) and l-lysine HCl are considered efficacious sources of the essential amino acid l-lysine for non-ruminant animal species. For the supplemental l-lysine to be as efficacious in ruminants as in non-ruminant species, it would require protection against degradation in the rumen.

KW - concentrated liquid l-lysine (base)

KW - Corynebacterium casei

KW - efficacy

KW - lysine monohydrochloride

KW - nutritional additive

KW - Safety

KW - their salts and analogues’

KW - ‘amino acids

U2 - 10.2903/j.efsa.2020.6285

DO - 10.2903/j.efsa.2020.6285

M3 - Journal article

C2 - 33204313

AN - SCOPUS:85097977545

VL - 18

JO - E F S A Journal

JF - E F S A Journal

SN - 1831-4732

IS - 11

M1 - e06285

ER -

ID: 259990145