Safety and efficacy of l-lysine monohydrochloride and concentrated liquid l-lysine (base) produced by fermentation with Corynebacterium glutamicum KCTC 12307BP as feed additives for all animal species
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning
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Safety and efficacy of l-lysine monohydrochloride and concentrated liquid l-lysine (base) produced by fermentation with Corynebacterium glutamicum KCTC 12307BP as feed additives for all animal species. / Bampidis, Vasileios; Azimonti, Giovanna; Bastos, Maria de Lourdes; Christensen, Henrik; Dusemund, Birgit; Durjava, Mojca Fašmon; Kouba, Maryline; López-Alonso, Marta; López Puente, Secundino; Marcon, Francesca; Mayo, Baltasar; Pechová, Alena; Petkova, Mariana; Ramos, Fernando; Sanz, Yolanda; Villa, Roberto Edoardo; Woutersen, Ruud; Cocconcelli, Pier Sandro; Glandorf, Boet; Herman, Lieve; Maradona, Miguel Prieto; Saarela, Maria; Anguita, Montserrat; Galobart, Jaume; Holczkencht, Orsolya; Manini, Paola; Pettenati, Elisa; Pizzo, Fabiola; Tarrés-Call, Jordi; EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP).
I: EFSA Journal, Bind 18, Nr. 12, e06333, 2020.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning
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TY - JOUR
T1 - Safety and efficacy of l-lysine monohydrochloride and concentrated liquid l-lysine (base) produced by fermentation with Corynebacterium glutamicum KCTC 12307BP as feed additives for all animal species
AU - Bampidis, Vasileios
AU - Azimonti, Giovanna
AU - Bastos, Maria de Lourdes
AU - Christensen, Henrik
AU - Dusemund, Birgit
AU - Durjava, Mojca Fašmon
AU - Kouba, Maryline
AU - López-Alonso, Marta
AU - López Puente, Secundino
AU - Marcon, Francesca
AU - Mayo, Baltasar
AU - Pechová, Alena
AU - Petkova, Mariana
AU - Ramos, Fernando
AU - Sanz, Yolanda
AU - Villa, Roberto Edoardo
AU - Woutersen, Ruud
AU - Cocconcelli, Pier Sandro
AU - Glandorf, Boet
AU - Herman, Lieve
AU - Maradona, Miguel Prieto
AU - Saarela, Maria
AU - Anguita, Montserrat
AU - Galobart, Jaume
AU - Holczkencht, Orsolya
AU - Manini, Paola
AU - Pettenati, Elisa
AU - Pizzo, Fabiola
AU - Tarrés-Call, Jordi
AU - EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)
PY - 2020
Y1 - 2020
N2 - Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety for the target animals, consumer, user and the environment and on the efficacy of a concentrated liquid l-lysine (base, minimum 50%) and a l-lysine monohydrochloride (HCl, minimum 99%) produced by fermentation with a genetically modified strain of Corynebacterium glutamicum (KCTC 12307BP). Both forms of l-lysine are intended to be used in feed for all animal species and categories. Neither the production strain nor its recombinant DNA were detected in the final products. The additives do not pose any safety concern associated with the genetic modification of the production strain. Concentrated liquid l-lysine (base) and l-lysine HCl produced by the strain C. glutamicumKCTC 12307BP do not represent a risk for the target species, for the consumer, for the user and for the environment. l-Lysine HCl and concentrated liquid l-lysine (base) are considered to be efficacious sources of the essential amino acid l-lysine for non-ruminant animal species. For the supplemental l-lysine to be as efficacious in ruminants as in non-ruminant species, it would require protection against degradation in the rumen.
AB - Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety for the target animals, consumer, user and the environment and on the efficacy of a concentrated liquid l-lysine (base, minimum 50%) and a l-lysine monohydrochloride (HCl, minimum 99%) produced by fermentation with a genetically modified strain of Corynebacterium glutamicum (KCTC 12307BP). Both forms of l-lysine are intended to be used in feed for all animal species and categories. Neither the production strain nor its recombinant DNA were detected in the final products. The additives do not pose any safety concern associated with the genetic modification of the production strain. Concentrated liquid l-lysine (base) and l-lysine HCl produced by the strain C. glutamicumKCTC 12307BP do not represent a risk for the target species, for the consumer, for the user and for the environment. l-Lysine HCl and concentrated liquid l-lysine (base) are considered to be efficacious sources of the essential amino acid l-lysine for non-ruminant animal species. For the supplemental l-lysine to be as efficacious in ruminants as in non-ruminant species, it would require protection against degradation in the rumen.
KW - concentrated liquid l-lysine (base)
KW - Corynebacterium glutamicumKCTC 12307BP
KW - feed additive
KW - l-lysine monohydrochloride
KW - recombinant DNA
KW - viable cells
U2 - 10.2903/j.efsa.2020.6333
DO - 10.2903/j.efsa.2020.6333
M3 - Journal article
C2 - 33391396
AN - SCOPUS:85098250415
VL - 18
JO - E F S A Journal
JF - E F S A Journal
SN - 1831-4732
IS - 12
M1 - e06333
ER -
ID: 255043555