TY - JOUR

T1 - Safety and efficacy of l-valine produced by fermentation using Corynebacterium glutamicumCGMCC 7.358 as a feed additive for all animal species

AU - Bampidis, Vasileios

AU - Azimonti, Giovanna

AU - Bastos, Maria de Lourdes

AU - Christensen, Henrik

AU - Dusemund, Birgit

AU - Fašmon Durjava, Mojca

AU - Kouba, Maryline

AU - López-Alonso, Marta

AU - López Puente, Secundino

AU - Marcon, Francesca

AU - Mayo, Baltasar

AU - Pechová, Alena

AU - Petkova, Mariana

AU - Ramos, Fernando

AU - Sanz, Yolanda

AU - Villa, Roberto Edoardo

AU - Woutersen, Ruud

AU - Cocconcelli, Pier Sandro

AU - Glandorf, Boet

AU - Herman, Lieve

AU - Maradona, Miguel Prieto

AU - Saarela, Maria

AU - Anguita, Montserrat

AU - Holczknecht, Orsolya

AU - Galobart, Jaume

AU - Manini, Paola

AU - Pettenati, Elisa

AU - Pizzo, Fabiola

AU - Tarrés-Call, Jordi

AU - EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)

PY - 2020

Y1 - 2020

N2 - Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on l-valine produced by fermentation using a non-genetically modified strain of Corynebacterium glutamicum (CGMCC 7.358). The additive is intended to be used in feed and water for drinking for all animal species and categories. The production strain meets the qualifications for the qualified presumption of safety (QPS) approach to safety assessment and is considered safe. l-Valine produced using C. glutamicumCGMCC 7.358 is safe for the target species when supplemented in appropriate amounts to the diet according to the nutritional needs of the target species, for the consumer and for the environment. No conclusion could be drawn on the potential of l-valine produced using C. glutamicumCGMCC 7.358 to be toxic by inhalation, irritant to the skin or eyes, or a dermal sensitiser due to the lack of data. The product l-valine produced by fermentation using C. glutamicumCGMCC 7.358 is regarded as an efficacious source of the essential amino acid l-valine for non-ruminant nutrition. For the supplemental l-valine to be as efficacious in ruminants as in non-ruminant species, it requires protection against degradation in the rumen.

AB - Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on l-valine produced by fermentation using a non-genetically modified strain of Corynebacterium glutamicum (CGMCC 7.358). The additive is intended to be used in feed and water for drinking for all animal species and categories. The production strain meets the qualifications for the qualified presumption of safety (QPS) approach to safety assessment and is considered safe. l-Valine produced using C. glutamicumCGMCC 7.358 is safe for the target species when supplemented in appropriate amounts to the diet according to the nutritional needs of the target species, for the consumer and for the environment. No conclusion could be drawn on the potential of l-valine produced using C. glutamicumCGMCC 7.358 to be toxic by inhalation, irritant to the skin or eyes, or a dermal sensitiser due to the lack of data. The product l-valine produced by fermentation using C. glutamicumCGMCC 7.358 is regarded as an efficacious source of the essential amino acid l-valine for non-ruminant nutrition. For the supplemental l-valine to be as efficacious in ruminants as in non-ruminant species, it requires protection against degradation in the rumen.

KW - amino acids

KW - C. glutamicumCGMCC 7.358

KW - efficacy

KW - l-valine

KW - nutritional additive

KW - safety

U2 - 10.2903/j.efsa.2020.6286

DO - 10.2903/j.efsa.2020.6286

M3 - Journal article

C2 - 33209151

AN - SCOPUS:85097092792

VL - 18

JO - E F S A Journal

JF - E F S A Journal

SN - 1831-4732

IS - 11

M1 - e06286

ER -