Sensitivity to oxazolone induced dermatitis is transferable with gut microbiota in mice

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Sensitivity to oxazolone induced dermatitis is transferable with gut microbiota in mice. / Fisker, Line; Krych, Lukasz; Engkilde, Kåre; Nielsen, Dennis Sandris; Kot, Witold Piotr; Hansen, Camilla Hartmann Friis; Hansen, Axel Kornerup.

I: Scientific Reports, Bind 7, 44385, 2017.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Fisker, L, Krych, L, Engkilde, K, Nielsen, DS, Kot, WP, Hansen, CHF & Hansen, AK 2017, 'Sensitivity to oxazolone induced dermatitis is transferable with gut microbiota in mice', Scientific Reports, bind 7, 44385. https://doi.org/10.1038/srep44385

APA

Fisker, L., Krych, L., Engkilde, K., Nielsen, D. S., Kot, W. P., Hansen, C. H. F., & Hansen, A. K. (2017). Sensitivity to oxazolone induced dermatitis is transferable with gut microbiota in mice. Scientific Reports, 7, [44385]. https://doi.org/10.1038/srep44385

Vancouver

Fisker L, Krych L, Engkilde K, Nielsen DS, Kot WP, Hansen CHF o.a. Sensitivity to oxazolone induced dermatitis is transferable with gut microbiota in mice. Scientific Reports. 2017;7. 44385. https://doi.org/10.1038/srep44385

Author

Fisker, Line ; Krych, Lukasz ; Engkilde, Kåre ; Nielsen, Dennis Sandris ; Kot, Witold Piotr ; Hansen, Camilla Hartmann Friis ; Hansen, Axel Kornerup. / Sensitivity to oxazolone induced dermatitis is transferable with gut microbiota in mice. I: Scientific Reports. 2017 ; Bind 7.

Bibtex

@article{27218a4b18c547dab9a6f7a5b3b67ddb,
title = "Sensitivity to oxazolone induced dermatitis is transferable with gut microbiota in mice",
abstract = "Atopic Dermatitis (AD) has been associated with gut microbiota (GM) dysbiosis in humans, indicating a causative role of GM in AD etiology. Furthermore, the GM strongly correlates to essential disease parameters in the well-known oxazolone-induced mouse model of AD. Here, we demonstrate that it is possible to transfer both a high-responding and a low-responding AD phenotype with GM from conventional mice to germ-free mice. The mice inoculated with the high-responding GM had significantly higher clinical score, increased ear thickness, and increased levels of IL-1β, TNFα, IL-4, IL-5, and IL-6 compared to the mice inoculated with the low-responding GM. The inter-individual variation was in general not affected by this increase in effect size. Germ-free mice induced with AD revealed a high disease response as well as high inter-individual variation indicating protective properties of certain microbial taxa in this model. This study underlines that the GM has a strong impact on AD in mouse models, and that the power of studies may be increased by the application of mice inoculated with a specific GM from high responders to increase the effect size.",
author = "Line Fisker and Lukasz Krych and K{\aa}re Engkilde and Nielsen, {Dennis Sandris} and Kot, {Witold Piotr} and Hansen, {Camilla Hartmann Friis} and Hansen, {Axel Kornerup}",
year = "2017",
doi = "10.1038/srep44385",
language = "English",
volume = "7",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Sensitivity to oxazolone induced dermatitis is transferable with gut microbiota in mice

AU - Fisker, Line

AU - Krych, Lukasz

AU - Engkilde, Kåre

AU - Nielsen, Dennis Sandris

AU - Kot, Witold Piotr

AU - Hansen, Camilla Hartmann Friis

AU - Hansen, Axel Kornerup

PY - 2017

Y1 - 2017

N2 - Atopic Dermatitis (AD) has been associated with gut microbiota (GM) dysbiosis in humans, indicating a causative role of GM in AD etiology. Furthermore, the GM strongly correlates to essential disease parameters in the well-known oxazolone-induced mouse model of AD. Here, we demonstrate that it is possible to transfer both a high-responding and a low-responding AD phenotype with GM from conventional mice to germ-free mice. The mice inoculated with the high-responding GM had significantly higher clinical score, increased ear thickness, and increased levels of IL-1β, TNFα, IL-4, IL-5, and IL-6 compared to the mice inoculated with the low-responding GM. The inter-individual variation was in general not affected by this increase in effect size. Germ-free mice induced with AD revealed a high disease response as well as high inter-individual variation indicating protective properties of certain microbial taxa in this model. This study underlines that the GM has a strong impact on AD in mouse models, and that the power of studies may be increased by the application of mice inoculated with a specific GM from high responders to increase the effect size.

AB - Atopic Dermatitis (AD) has been associated with gut microbiota (GM) dysbiosis in humans, indicating a causative role of GM in AD etiology. Furthermore, the GM strongly correlates to essential disease parameters in the well-known oxazolone-induced mouse model of AD. Here, we demonstrate that it is possible to transfer both a high-responding and a low-responding AD phenotype with GM from conventional mice to germ-free mice. The mice inoculated with the high-responding GM had significantly higher clinical score, increased ear thickness, and increased levels of IL-1β, TNFα, IL-4, IL-5, and IL-6 compared to the mice inoculated with the low-responding GM. The inter-individual variation was in general not affected by this increase in effect size. Germ-free mice induced with AD revealed a high disease response as well as high inter-individual variation indicating protective properties of certain microbial taxa in this model. This study underlines that the GM has a strong impact on AD in mouse models, and that the power of studies may be increased by the application of mice inoculated with a specific GM from high responders to increase the effect size.

U2 - 10.1038/srep44385

DO - 10.1038/srep44385

M3 - Journal article

C2 - 28290517

AN - SCOPUS:85015307682

VL - 7

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 44385

ER -

ID: 176656151