TY - JOUR

T1 - Spatial discrimination and visual discrimination

T2 - two methods evaluating learning and memory in juvenile Gottingen minipigs

AU - Haagensen, Annika M. J.

AU - Grand, Nanna

AU - Klastrup, Signe

AU - Skytte, Christina

AU - Sorensen, Dorte B.

PY - 2013

Y1 - 2013

N2 - Two methods investigating learning and memory in juvenile Gottingen minipigs were evaluated for potential use in preclinical toxicity testing. Twelve minipigs were tested using a spatial hole-board discrimination test including a learning phase and two memory phases. Five minipigs were tested in a visual discrimination test. The juvenile minipigs were able to learn the spatial hole-board discrimination test and showed improved working and reference memory during the learning phase. Performance in the memory phases was affected by the retention intervals, but the minipigs were able to remember the concept of the test in both memory phases. Working memory and reference memory were significantly improved in the last trials of the memory phases. In the visual discrimination test, the minipigs learned to discriminate between the three figures presented to them within 9-14 sessions. For the memory test, all minipigs performed 9/12 correct choices or better. Juvenile Gottingen minipigs are able to learn to perform in a spatial hole-board discrimination test as well as in a visual discrimination test, showing an increase in performance over time. Both tests have considerable scope to assess learning and memory of pigs, and we seem to have succeeded in establishing two test systems suitable for performing preclinical toxicity testing in juvenile minipigs. Behavioural Pharmacology 24: 172-179 (C) 2013 Wolters Kluwer Health vertical bar Lippincott Williams Wilkins. Behavioural Pharmacology 2013, 24: 172-179

AB - Two methods investigating learning and memory in juvenile Gottingen minipigs were evaluated for potential use in preclinical toxicity testing. Twelve minipigs were tested using a spatial hole-board discrimination test including a learning phase and two memory phases. Five minipigs were tested in a visual discrimination test. The juvenile minipigs were able to learn the spatial hole-board discrimination test and showed improved working and reference memory during the learning phase. Performance in the memory phases was affected by the retention intervals, but the minipigs were able to remember the concept of the test in both memory phases. Working memory and reference memory were significantly improved in the last trials of the memory phases. In the visual discrimination test, the minipigs learned to discriminate between the three figures presented to them within 9-14 sessions. For the memory test, all minipigs performed 9/12 correct choices or better. Juvenile Gottingen minipigs are able to learn to perform in a spatial hole-board discrimination test as well as in a visual discrimination test, showing an increase in performance over time. Both tests have considerable scope to assess learning and memory of pigs, and we seem to have succeeded in establishing two test systems suitable for performing preclinical toxicity testing in juvenile minipigs. Behavioural Pharmacology 24: 172-179 (C) 2013 Wolters Kluwer Health vertical bar Lippincott Williams Wilkins. Behavioural Pharmacology 2013, 24: 172-179

U2 - 10.1097/FBP.0b013e32836104fd

DO - 10.1097/FBP.0b013e32836104fd

M3 - Journal article

C2 - 23542905

VL - 24

SP - 172

EP - 179

JO - Behavioural Pharmacology

JF - Behavioural Pharmacology

SN - 0955-8810

IS - 3

ER -