The inflammatory response to bone infection – a review based on animal models and human patients
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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The inflammatory response to bone infection – a review based on animal models and human patients. / Lüthje, Freja Lea; Jensen, Louise Kruse; Jensen, Henrik Elvang; Skovgaard, Kerstin.
I: APMIS, Bind 128, Nr. 4, 2020, s. 275-286.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - The inflammatory response to bone infection – a review based on animal models and human patients
AU - Lüthje, Freja Lea
AU - Jensen, Louise Kruse
AU - Jensen, Henrik Elvang
AU - Skovgaard, Kerstin
PY - 2020
Y1 - 2020
N2 - Bone infections are difficult to diagnose and treat, especially when a prosthetic joint replacement or implant is involved. Bone loss is a major complication of osteomyelitis, but the mechanism behind has mainly been investigated in cell cultures and has not been confirmed in human settings. Inflammation is important in initiating an appropriate immune response to invading pathogens. However, many of the signaling molecules used by the immune system can also modulate bone remodeling and contribute to bone resorption during osteomyelitis. Our current knowledge of the inflammatory response relies heavily on animal models as research based on human samples is scarce. Staphylococcus aureus is one of the most common causes of bone infections and is the pathogen of choice in animal models. The regulation of inflammatory genes during prosthetic joint infections and implant-associated osteomyelitis has only been studied in rodent models. It is important to consider the validity of an animal model when results are extrapolated to humans, and both bone composition and the immune system of pigs has been shown to be more similar to humans, than to rodents. Here in vivo studies on the inflammatory response to prosthetic joint infections and implant-associated osteomyelitis are reviewed.
AB - Bone infections are difficult to diagnose and treat, especially when a prosthetic joint replacement or implant is involved. Bone loss is a major complication of osteomyelitis, but the mechanism behind has mainly been investigated in cell cultures and has not been confirmed in human settings. Inflammation is important in initiating an appropriate immune response to invading pathogens. However, many of the signaling molecules used by the immune system can also modulate bone remodeling and contribute to bone resorption during osteomyelitis. Our current knowledge of the inflammatory response relies heavily on animal models as research based on human samples is scarce. Staphylococcus aureus is one of the most common causes of bone infections and is the pathogen of choice in animal models. The regulation of inflammatory genes during prosthetic joint infections and implant-associated osteomyelitis has only been studied in rodent models. It is important to consider the validity of an animal model when results are extrapolated to humans, and both bone composition and the immune system of pigs has been shown to be more similar to humans, than to rodents. Here in vivo studies on the inflammatory response to prosthetic joint infections and implant-associated osteomyelitis are reviewed.
KW - cytokines
KW - immune response
KW - inflammation
KW - osteomyelitis
KW - prosthetic joint infection
U2 - 10.1111/apm.13027
DO - 10.1111/apm.13027
M3 - Review
C2 - 31976582
AN - SCOPUS:85079542440
VL - 128
SP - 275
EP - 286
JO - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica
JF - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica
SN - 0903-4641
IS - 4
ER -
ID: 239015231