The origin of Pasteurella multocida impacts pathology and inflammation when assessed in a mouse model

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Standard

The origin of Pasteurella multocida impacts pathology and inflammation when assessed in a mouse model. / Pors, Susanne E.; Chadfield, Mark S.; Sorensen, Dorte B.; Offenberg, Hanne; Bisgaard, Magne; Jensen, Henrik E.

I: Research in Veterinary Science, Bind 105, 04.2016, s. 139-142.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Pors, SE, Chadfield, MS, Sorensen, DB, Offenberg, H, Bisgaard, M & Jensen, HE 2016, 'The origin of Pasteurella multocida impacts pathology and inflammation when assessed in a mouse model', Research in Veterinary Science, bind 105, s. 139-142. https://doi.org/10.1016/j.rvsc.2016.02.007

APA

Pors, S. E., Chadfield, M. S., Sorensen, D. B., Offenberg, H., Bisgaard, M., & Jensen, H. E. (2016). The origin of Pasteurella multocida impacts pathology and inflammation when assessed in a mouse model. Research in Veterinary Science, 105, 139-142. https://doi.org/10.1016/j.rvsc.2016.02.007

Vancouver

Pors SE, Chadfield MS, Sorensen DB, Offenberg H, Bisgaard M, Jensen HE. The origin of Pasteurella multocida impacts pathology and inflammation when assessed in a mouse model. Research in Veterinary Science. 2016 apr.;105:139-142. https://doi.org/10.1016/j.rvsc.2016.02.007

Author

Pors, Susanne E. ; Chadfield, Mark S. ; Sorensen, Dorte B. ; Offenberg, Hanne ; Bisgaard, Magne ; Jensen, Henrik E. / The origin of Pasteurella multocida impacts pathology and inflammation when assessed in a mouse model. I: Research in Veterinary Science. 2016 ; Bind 105. s. 139-142.

Bibtex

@article{09a02d8c4f4944bd8d3fc78c07c478ab,
title = "The origin of Pasteurella multocida impacts pathology and inflammation when assessed in a mouse model",
abstract = "Host-pathogen interactions of Pasteurella multocida isolates of different origin were studied in a mouse model, focusing on pathology, bacterial load and expression of the metalloproteinase MMP9 and its inhibitor TIMP1. Intranasal inoculation with one of three doses (10(6), 10(4), 10(2) CFU) of an isolate from porcine pneumonia or fowl cholera showed marked differences between the two isolates. The avian isolate was highly pathogenic with severe signs of necrotizing pneumonia, liver necrosis and high bacterial load in lung and liver. Clinical signs and pathology related to the porcine isolate were dose dependent and consisted of exudative bronchopneumonia, abscess formation in liver and a lower bacterial load in lung and liver. Both isolates caused increased expression of MMP9 and TIMP1. In conclusion, evaluation and comparison of pathogenicity and host-pathogen interaction of P. multocida isolates from different hosts is possible in the intranasal murine model.",
keywords = "Fowl cholera, Mouse model, Pasteurella multocida, Porcine pneumonia",
author = "Pors, {Susanne E.} and Chadfield, {Mark S.} and Sorensen, {Dorte B.} and Hanne Offenberg and Magne Bisgaard and Jensen, {Henrik E.}",
year = "2016",
month = apr,
doi = "10.1016/j.rvsc.2016.02.007",
language = "English",
volume = "105",
pages = "139--142",
journal = "Research in Veterinary Science",
issn = "0034-5288",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - The origin of Pasteurella multocida impacts pathology and inflammation when assessed in a mouse model

AU - Pors, Susanne E.

AU - Chadfield, Mark S.

AU - Sorensen, Dorte B.

AU - Offenberg, Hanne

AU - Bisgaard, Magne

AU - Jensen, Henrik E.

PY - 2016/4

Y1 - 2016/4

N2 - Host-pathogen interactions of Pasteurella multocida isolates of different origin were studied in a mouse model, focusing on pathology, bacterial load and expression of the metalloproteinase MMP9 and its inhibitor TIMP1. Intranasal inoculation with one of three doses (10(6), 10(4), 10(2) CFU) of an isolate from porcine pneumonia or fowl cholera showed marked differences between the two isolates. The avian isolate was highly pathogenic with severe signs of necrotizing pneumonia, liver necrosis and high bacterial load in lung and liver. Clinical signs and pathology related to the porcine isolate were dose dependent and consisted of exudative bronchopneumonia, abscess formation in liver and a lower bacterial load in lung and liver. Both isolates caused increased expression of MMP9 and TIMP1. In conclusion, evaluation and comparison of pathogenicity and host-pathogen interaction of P. multocida isolates from different hosts is possible in the intranasal murine model.

AB - Host-pathogen interactions of Pasteurella multocida isolates of different origin were studied in a mouse model, focusing on pathology, bacterial load and expression of the metalloproteinase MMP9 and its inhibitor TIMP1. Intranasal inoculation with one of three doses (10(6), 10(4), 10(2) CFU) of an isolate from porcine pneumonia or fowl cholera showed marked differences between the two isolates. The avian isolate was highly pathogenic with severe signs of necrotizing pneumonia, liver necrosis and high bacterial load in lung and liver. Clinical signs and pathology related to the porcine isolate were dose dependent and consisted of exudative bronchopneumonia, abscess formation in liver and a lower bacterial load in lung and liver. Both isolates caused increased expression of MMP9 and TIMP1. In conclusion, evaluation and comparison of pathogenicity and host-pathogen interaction of P. multocida isolates from different hosts is possible in the intranasal murine model.

KW - Fowl cholera

KW - Mouse model

KW - Pasteurella multocida

KW - Porcine pneumonia

U2 - 10.1016/j.rvsc.2016.02.007

DO - 10.1016/j.rvsc.2016.02.007

M3 - Journal article

C2 - 27033923

VL - 105

SP - 139

EP - 142

JO - Research in Veterinary Science

JF - Research in Veterinary Science

SN - 0034-5288

ER -

ID: 165751765