TY - JOUR

T1 - Transfer of amoxicillin to suckling mink (Neovison vison) kits via the milk from dams treated orally or intra-muscularly

AU - Birch, Julie Melsted

AU - Frandsen, Henrik Lauritz

AU - Struve, Tina

AU - Agger, Jens Frederik

AU - Jensen, Henrik Elvang

PY - 2019

Y1 - 2019

N2 - Treatment of mink kits with pre-weaning diarrhea (PWD) can be time-consuming and expensive for the farmer, and the efficacy of the treatment procedure may be questioned. Evidence-based treatment protocols for application on affected animals at farms with outbreaks of PWD are lacking. In Denmark, the dams are sometimes treated with amoxicillin, however, it is unknown if it is passed on to the mink kits via the milk. The aim of the present study was to investigate if amoxicillin is transferred via the milk to the kits after oral (PO) and intramuscular (IM) treatment, respectively, of the dam. Moreover, we estimated the concentrations of amoxicillin continuously in serum from the kits up to 8 h after administration. The concentration of amoxicillin was not affected by the route of administration (P =.64) and serum reached the highest level after 8 h (34 ng/mL, CI95% = [24.3–47.7]). The serum concentrations of amoxicillin in the mink kits achieved within 8 h were judged too low to exert antimicrobial impact on relevant bacterial species.

AB - Treatment of mink kits with pre-weaning diarrhea (PWD) can be time-consuming and expensive for the farmer, and the efficacy of the treatment procedure may be questioned. Evidence-based treatment protocols for application on affected animals at farms with outbreaks of PWD are lacking. In Denmark, the dams are sometimes treated with amoxicillin, however, it is unknown if it is passed on to the mink kits via the milk. The aim of the present study was to investigate if amoxicillin is transferred via the milk to the kits after oral (PO) and intramuscular (IM) treatment, respectively, of the dam. Moreover, we estimated the concentrations of amoxicillin continuously in serum from the kits up to 8 h after administration. The concentration of amoxicillin was not affected by the route of administration (P =.64) and serum reached the highest level after 8 h (34 ng/mL, CI95% = [24.3–47.7]). The serum concentrations of amoxicillin in the mink kits achieved within 8 h were judged too low to exert antimicrobial impact on relevant bacterial species.

KW - Intra-muscular

KW - Lactation period

KW - Oral

KW - Pharmacokinetics

KW - Pre-weaning diarrhea

KW - Sticky kits

U2 - 10.1016/j.rvsc.2018.12.008

DO - 10.1016/j.rvsc.2018.12.008

M3 - Journal article

C2 - 30586651

AN - SCOPUS:85058800701

VL - 123

SP - 47

EP - 50

JO - Research in Veterinary Science

JF - Research in Veterinary Science

SN - 0034-5288

ER -