Trichuris suis secrete products that reduce disease severity in a multiple sclerosis model
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Trichuris suis secrete products that reduce disease severity in a multiple sclerosis model. / Hansen, Christine Soholm; Hasseldam, Henrik; Bacher, Idahella Hyldgaard; Thamsborg, Stig Milan; Johansen, Flemming Fryd; Kringel, Helene.
I: Acta Parasitologica, Bind 62, Nr. 1, 03.2017, s. 22-28.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Trichuris suis secrete products that reduce disease severity in a multiple sclerosis model
AU - Hansen, Christine Soholm
AU - Hasseldam, Henrik
AU - Bacher, Idahella Hyldgaard
AU - Thamsborg, Stig Milan
AU - Johansen, Flemming Fryd
AU - Kringel, Helene
PY - 2017/3
Y1 - 2017/3
N2 - Multiple sclerosis is a chronic inflammatory central nervous system (CNS) disease, which affects about 1 in 1000 individuals in the western world. It has been suggested that this relatively high prevalence is linked to a high level of hygiene, i.e. a reduced exposure to various microorganisms, including parasites. Parasites are known to employ different immunomodulatory and antiinflammatory strategies, which enable them to evade destruction by the immune system. We have investigated the immunomodulation by the swine whipworm, Trichuris suis, by measuring the impact of oral administration of T. suis ova as well as of intraperitoneal administration of T. suis excretory/secretory products on the development and progression of experimental autoimmune encephalomyelitis – an animal model that shares clinical and pathological characteristics with multiple sclerosis. Intraperitoneal administration of excretory/secretory products before disease onset, resulted in a significant decrease in disease severity as well as markedly reduced TH1 and TH17 T-cell responses, centrally in the spinal cord as well as in the periphery, i.e. the spleen. Thus, parenteral administration of T. suis-derived products results in a skewing of the immune response with a significant impact on disease severity in a CNS inflammatory disease model.
AB - Multiple sclerosis is a chronic inflammatory central nervous system (CNS) disease, which affects about 1 in 1000 individuals in the western world. It has been suggested that this relatively high prevalence is linked to a high level of hygiene, i.e. a reduced exposure to various microorganisms, including parasites. Parasites are known to employ different immunomodulatory and antiinflammatory strategies, which enable them to evade destruction by the immune system. We have investigated the immunomodulation by the swine whipworm, Trichuris suis, by measuring the impact of oral administration of T. suis ova as well as of intraperitoneal administration of T. suis excretory/secretory products on the development and progression of experimental autoimmune encephalomyelitis – an animal model that shares clinical and pathological characteristics with multiple sclerosis. Intraperitoneal administration of excretory/secretory products before disease onset, resulted in a significant decrease in disease severity as well as markedly reduced TH1 and TH17 T-cell responses, centrally in the spinal cord as well as in the periphery, i.e. the spleen. Thus, parenteral administration of T. suis-derived products results in a skewing of the immune response with a significant impact on disease severity in a CNS inflammatory disease model.
KW - Trichuris suis
KW - multiple sclerosis
KW - immunomodulation
KW - t-cells
U2 - 10.1515/ap-2017-0002
DO - 10.1515/ap-2017-0002
M3 - Journal article
C2 - 28030334
VL - 62
SP - 22
EP - 28
JO - Acta Parasitologica
JF - Acta Parasitologica
SN - 1230-2821
IS - 1
ER -
ID: 173507936