Validation of DNA test for hip dysplasia failed in Danish Labrador Retrievers

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Validation of DNA test for hip dysplasia failed in Danish Labrador Retrievers. / Bruun, C. S.; Bank, A.; Ström, A.; Proschowsky, H. F.; Fredholm, M.

I: Animal Genetics, Bind 51, Nr. 4, 2020, s. 617-619.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Bruun, CS, Bank, A, Ström, A, Proschowsky, HF & Fredholm, M 2020, 'Validation of DNA test for hip dysplasia failed in Danish Labrador Retrievers', Animal Genetics, bind 51, nr. 4, s. 617-619. https://doi.org/10.1111/age.12951

APA

Bruun, C. S., Bank, A., Ström, A., Proschowsky, H. F., & Fredholm, M. (2020). Validation of DNA test for hip dysplasia failed in Danish Labrador Retrievers. Animal Genetics, 51(4), 617-619. https://doi.org/10.1111/age.12951

Vancouver

Bruun CS, Bank A, Ström A, Proschowsky HF, Fredholm M. Validation of DNA test for hip dysplasia failed in Danish Labrador Retrievers. Animal Genetics. 2020;51(4):617-619. https://doi.org/10.1111/age.12951

Author

Bruun, C. S. ; Bank, A. ; Ström, A. ; Proschowsky, H. F. ; Fredholm, M. / Validation of DNA test for hip dysplasia failed in Danish Labrador Retrievers. I: Animal Genetics. 2020 ; Bind 51, Nr. 4. s. 617-619.

Bibtex

@article{d4aeec8f08cf485aac025396f5f7d3ac,
title = "Validation of DNA test for hip dysplasia failed in Danish Labrador Retrievers",
abstract = "Canine hip dysplasia is characterized by poor hip joint conformation and laxity. The disease is a complex trait influenced by both genetics and environment. Diagnosis and quantification of hip dysplasia are performed by radiographic examination of the hip joint and the diagnosis is used for making breeding decisions in many breeds. A prognostic genetic test (the Dysgen test) based on seven associated SNPs has been developed in a study based on Spanish Labrador Retrievers. In our study this test has been evaluated in 39 Danish Labrador Retrievers with known radiographic hip score: 14 with hip dysplasia (grade D or E) and 25 without hip dysplasia (grade A or B). There was no significant correlation between the Dysgen test results and the radiographic hip status (P = 0.3203) in these dogs, indicating that Dysgen test results obtained for Danish Labrador Retrievers have no prognostic value.",
keywords = "canine hip dysplasia, genotyping",
author = "Bruun, {C. S.} and A. Bank and A. Str{\"o}m and Proschowsky, {H. F.} and M. Fredholm",
year = "2020",
doi = "10.1111/age.12951",
language = "English",
volume = "51",
pages = "617--619",
journal = "Animal Genetics",
issn = "0268-9146",
publisher = "Wiley-Blackwell",
number = "4",

}

RIS

TY - JOUR

T1 - Validation of DNA test for hip dysplasia failed in Danish Labrador Retrievers

AU - Bruun, C. S.

AU - Bank, A.

AU - Ström, A.

AU - Proschowsky, H. F.

AU - Fredholm, M.

PY - 2020

Y1 - 2020

N2 - Canine hip dysplasia is characterized by poor hip joint conformation and laxity. The disease is a complex trait influenced by both genetics and environment. Diagnosis and quantification of hip dysplasia are performed by radiographic examination of the hip joint and the diagnosis is used for making breeding decisions in many breeds. A prognostic genetic test (the Dysgen test) based on seven associated SNPs has been developed in a study based on Spanish Labrador Retrievers. In our study this test has been evaluated in 39 Danish Labrador Retrievers with known radiographic hip score: 14 with hip dysplasia (grade D or E) and 25 without hip dysplasia (grade A or B). There was no significant correlation between the Dysgen test results and the radiographic hip status (P = 0.3203) in these dogs, indicating that Dysgen test results obtained for Danish Labrador Retrievers have no prognostic value.

AB - Canine hip dysplasia is characterized by poor hip joint conformation and laxity. The disease is a complex trait influenced by both genetics and environment. Diagnosis and quantification of hip dysplasia are performed by radiographic examination of the hip joint and the diagnosis is used for making breeding decisions in many breeds. A prognostic genetic test (the Dysgen test) based on seven associated SNPs has been developed in a study based on Spanish Labrador Retrievers. In our study this test has been evaluated in 39 Danish Labrador Retrievers with known radiographic hip score: 14 with hip dysplasia (grade D or E) and 25 without hip dysplasia (grade A or B). There was no significant correlation between the Dysgen test results and the radiographic hip status (P = 0.3203) in these dogs, indicating that Dysgen test results obtained for Danish Labrador Retrievers have no prognostic value.

KW - canine hip dysplasia

KW - genotyping

U2 - 10.1111/age.12951

DO - 10.1111/age.12951

M3 - Journal article

C2 - 32432791

AN - SCOPUS:85085012784

VL - 51

SP - 617

EP - 619

JO - Animal Genetics

JF - Animal Genetics

SN - 0268-9146

IS - 4

ER -

ID: 242782214