Whipworm Infection in Mice Increases Coinfection of Enteric Pathogens but Promotes Clearance of Ascaris Larvae From the Lungs

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Whipworm Infection in Mice Increases Coinfection of Enteric Pathogens but Promotes Clearance of Ascaris Larvae From the Lungs. / Polakovicova, Nina; Adji, Antonia Vania; Myhill, Laura J.; Williams, Andrew R.

In: Journal of Infectious Diseases, Vol. 227, No. 12, 2023, p. 1428-1432.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Polakovicova, N, Adji, AV, Myhill, LJ & Williams, AR 2023, 'Whipworm Infection in Mice Increases Coinfection of Enteric Pathogens but Promotes Clearance of Ascaris Larvae From the Lungs', Journal of Infectious Diseases, vol. 227, no. 12, pp. 1428-1432. https://doi.org/10.1093/infdis/jiad063

APA

Polakovicova, N., Adji, A. V., Myhill, L. J., & Williams, A. R. (2023). Whipworm Infection in Mice Increases Coinfection of Enteric Pathogens but Promotes Clearance of Ascaris Larvae From the Lungs. Journal of Infectious Diseases, 227(12), 1428-1432. https://doi.org/10.1093/infdis/jiad063

Vancouver

Polakovicova N, Adji AV, Myhill LJ, Williams AR. Whipworm Infection in Mice Increases Coinfection of Enteric Pathogens but Promotes Clearance of Ascaris Larvae From the Lungs. Journal of Infectious Diseases. 2023;227(12):1428-1432. https://doi.org/10.1093/infdis/jiad063

Author

Polakovicova, Nina ; Adji, Antonia Vania ; Myhill, Laura J. ; Williams, Andrew R. / Whipworm Infection in Mice Increases Coinfection of Enteric Pathogens but Promotes Clearance of Ascaris Larvae From the Lungs. In: Journal of Infectious Diseases. 2023 ; Vol. 227, No. 12. pp. 1428-1432.

Bibtex

@article{d4666c73d7524e0e948d8b08e35d3e53,
title = "Whipworm Infection in Mice Increases Coinfection of Enteric Pathogens but Promotes Clearance of Ascaris Larvae From the Lungs",
abstract = "Infection with intestinal whipworms (Trichuris spp.) causes widespread morbidity and may alter responses to enteric and extraintestinal coinfections. Here, we show that Trichuris muris infection in mice increases coinfection with 2 evolutionary divergent enteric pathogens, the bacterium Citrobacter rodentium and the helminth Heligmosomoides polygyrus. Coinfection caused reduced weight gain and promoted type 1–biased inflammation. In contrast, T. muris–infected mice were more resistant to migrating Ascaris suum larvae in the lungs. Our results highlight the divergent nature of pathogen interactions and suggest that whipworm infection is a risk factor for coinfections with other pathogens within the gastrointestinal tract.",
keywords = "Citrobacter, coinfection, helminth, Trichuris, whipworm",
author = "Nina Polakovicova and Adji, {Antonia Vania} and Myhill, {Laura J.} and Williams, {Andrew R.}",
note = "Funding Information: Financial support . This work was supported by Independent Research Fund Denmark (grant 7026-0094B). Publisher Copyright: {\textcopyright} The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved.",
year = "2023",
doi = "10.1093/infdis/jiad063",
language = "English",
volume = "227",
pages = "1428--1432",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "12",

}

RIS

TY - JOUR

T1 - Whipworm Infection in Mice Increases Coinfection of Enteric Pathogens but Promotes Clearance of Ascaris Larvae From the Lungs

AU - Polakovicova, Nina

AU - Adji, Antonia Vania

AU - Myhill, Laura J.

AU - Williams, Andrew R.

N1 - Funding Information: Financial support . This work was supported by Independent Research Fund Denmark (grant 7026-0094B). Publisher Copyright: © The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved.

PY - 2023

Y1 - 2023

N2 - Infection with intestinal whipworms (Trichuris spp.) causes widespread morbidity and may alter responses to enteric and extraintestinal coinfections. Here, we show that Trichuris muris infection in mice increases coinfection with 2 evolutionary divergent enteric pathogens, the bacterium Citrobacter rodentium and the helminth Heligmosomoides polygyrus. Coinfection caused reduced weight gain and promoted type 1–biased inflammation. In contrast, T. muris–infected mice were more resistant to migrating Ascaris suum larvae in the lungs. Our results highlight the divergent nature of pathogen interactions and suggest that whipworm infection is a risk factor for coinfections with other pathogens within the gastrointestinal tract.

AB - Infection with intestinal whipworms (Trichuris spp.) causes widespread morbidity and may alter responses to enteric and extraintestinal coinfections. Here, we show that Trichuris muris infection in mice increases coinfection with 2 evolutionary divergent enteric pathogens, the bacterium Citrobacter rodentium and the helminth Heligmosomoides polygyrus. Coinfection caused reduced weight gain and promoted type 1–biased inflammation. In contrast, T. muris–infected mice were more resistant to migrating Ascaris suum larvae in the lungs. Our results highlight the divergent nature of pathogen interactions and suggest that whipworm infection is a risk factor for coinfections with other pathogens within the gastrointestinal tract.

KW - Citrobacter

KW - coinfection

KW - helminth

KW - Trichuris

KW - whipworm

U2 - 10.1093/infdis/jiad063

DO - 10.1093/infdis/jiad063

M3 - Journal article

C2 - 36932044

AN - SCOPUS:85163419785

VL - 227

SP - 1428

EP - 1432

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 12

ER -

ID: 361079946