Whipworm Infection in Mice Increases Coinfection of Enteric Pathogens but Promotes Clearance of Ascaris Larvae From the Lungs
Research output: Contribution to journal › Journal article › Research › peer-review
Infection with intestinal whipworms (Trichuris spp.) causes widespread morbidity and may alter responses to enteric and extraintestinal coinfections. Here, we show that Trichuris muris infection in mice increases coinfection with 2 evolutionary divergent enteric pathogens, the bacterium Citrobacter rodentium and the helminth Heligmosomoides polygyrus. Coinfection caused reduced weight gain and promoted type 1–biased inflammation. In contrast, T. muris–infected mice were more resistant to migrating Ascaris suum larvae in the lungs. Our results highlight the divergent nature of pathogen interactions and suggest that whipworm infection is a risk factor for coinfections with other pathogens within the gastrointestinal tract.
Original language | English |
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Journal | Journal of Infectious Diseases |
Volume | 227 |
Issue number | 12 |
Pages (from-to) | 1428-1432 |
Number of pages | 5 |
ISSN | 0022-1899 |
DOIs | |
Publication status | Published - 2023 |
Bibliographical note
Funding Information:
Financial support . This work was supported by Independent Research Fund Denmark (grant 7026-0094B).
Publisher Copyright:
© The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved.
- Citrobacter, coinfection, helminth, Trichuris, whipworm
Research areas
ID: 361079946