Mitral valve transcriptome analysis in thirty-four age-matched Cavalier King Charles Spaniels with or without congestive heart failure caused by myxomatous mitral valve disease

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Mitral valve transcriptome analysis in thirty-four age-matched Cavalier King Charles Spaniels with or without congestive heart failure caused by myxomatous mitral valve disease. / Reimann, Maria J.; Cremer, Signe; Christiansen, Liselotte; Ibragimov, Emil; Gao, Fei; Cirera, Susanna; Fredholm, Merete; Olsen, Lisbeth H.; Karlskov-Mortensen, Peter.

In: Mammalian Genome, Vol. 35, No. 1, 2024, p. 77-89.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Reimann, MJ, Cremer, S, Christiansen, L, Ibragimov, E, Gao, F, Cirera, S, Fredholm, M, Olsen, LH & Karlskov-Mortensen, P 2024, 'Mitral valve transcriptome analysis in thirty-four age-matched Cavalier King Charles Spaniels with or without congestive heart failure caused by myxomatous mitral valve disease', Mammalian Genome, vol. 35, no. 1, pp. 77-89. https://doi.org/10.1007/s00335-023-10024-1

APA

Reimann, M. J., Cremer, S., Christiansen, L., Ibragimov, E., Gao, F., Cirera, S., Fredholm, M., Olsen, L. H., & Karlskov-Mortensen, P. (2024). Mitral valve transcriptome analysis in thirty-four age-matched Cavalier King Charles Spaniels with or without congestive heart failure caused by myxomatous mitral valve disease. Mammalian Genome, 35(1), 77-89. https://doi.org/10.1007/s00335-023-10024-1

Vancouver

Reimann MJ, Cremer S, Christiansen L, Ibragimov E, Gao F, Cirera S et al. Mitral valve transcriptome analysis in thirty-four age-matched Cavalier King Charles Spaniels with or without congestive heart failure caused by myxomatous mitral valve disease. Mammalian Genome. 2024;35(1):77-89. https://doi.org/10.1007/s00335-023-10024-1

Author

Reimann, Maria J. ; Cremer, Signe ; Christiansen, Liselotte ; Ibragimov, Emil ; Gao, Fei ; Cirera, Susanna ; Fredholm, Merete ; Olsen, Lisbeth H. ; Karlskov-Mortensen, Peter. / Mitral valve transcriptome analysis in thirty-four age-matched Cavalier King Charles Spaniels with or without congestive heart failure caused by myxomatous mitral valve disease. In: Mammalian Genome. 2024 ; Vol. 35, No. 1. pp. 77-89.

Bibtex

@article{d6b505ae1fd54e388913d3bb8958816e,
title = "Mitral valve transcriptome analysis in thirty-four age-matched Cavalier King Charles Spaniels with or without congestive heart failure caused by myxomatous mitral valve disease",
abstract = "We here report the results of a mitral valve transcriptome study designed to identify genes and molecular pathways involved in development of congestive heart failure (CHF) following myxomatous mitral valve disease (MMVD) in dogs. The study is focused on a cohort of elderly age-matched dogs (n = 34, age ~ 10 years) from a single breed—Cavalier King Charles Spaniels (CKCS)—with a high incidence of MMVD. The cohort comprises 19 dogs (10♀, 9♂) without MMVD-associated CHF, and 15 dogs (6♀, 9♂) with CHF caused by MMVD; i.e., we compare gene expression in breed and age-matched groups of dogs, which only differ with respect to CHF status. We identify 56 genes, which are differentially expressed between the two groups. In this list of genes, we confirm an enrichment of genes related to the TNFβ-signaling pathway, extracellular matrix organization, vascular development, and endothelium damage, which also have been identified in previous studies. However, the genes with the greatest difference in expression between the two groups are CNTN3 and MYH1. Both genes encode proteins, which are predicted to have an effect on the contractile activity of myocardial cells, which in turn may have an effect on valvular performance and hemodynamics across the mitral valve. This may result in shear forces with impact on MMVD progression.",
author = "Reimann, {Maria J.} and Signe Cremer and Liselotte Christiansen and Emil Ibragimov and Fei Gao and Susanna Cirera and Merete Fredholm and Olsen, {Lisbeth H.} and Peter Karlskov-Mortensen",
note = "Publisher Copyright: {\textcopyright} The Author(s) 2023.",
year = "2024",
doi = "10.1007/s00335-023-10024-1",
language = "English",
volume = "35",
pages = "77--89",
journal = "Mammalian Genome",
issn = "0938-8990",
publisher = "Springer",
number = "1",

}

RIS

TY - JOUR

T1 - Mitral valve transcriptome analysis in thirty-four age-matched Cavalier King Charles Spaniels with or without congestive heart failure caused by myxomatous mitral valve disease

AU - Reimann, Maria J.

AU - Cremer, Signe

AU - Christiansen, Liselotte

AU - Ibragimov, Emil

AU - Gao, Fei

AU - Cirera, Susanna

AU - Fredholm, Merete

AU - Olsen, Lisbeth H.

AU - Karlskov-Mortensen, Peter

N1 - Publisher Copyright: © The Author(s) 2023.

PY - 2024

Y1 - 2024

N2 - We here report the results of a mitral valve transcriptome study designed to identify genes and molecular pathways involved in development of congestive heart failure (CHF) following myxomatous mitral valve disease (MMVD) in dogs. The study is focused on a cohort of elderly age-matched dogs (n = 34, age ~ 10 years) from a single breed—Cavalier King Charles Spaniels (CKCS)—with a high incidence of MMVD. The cohort comprises 19 dogs (10♀, 9♂) without MMVD-associated CHF, and 15 dogs (6♀, 9♂) with CHF caused by MMVD; i.e., we compare gene expression in breed and age-matched groups of dogs, which only differ with respect to CHF status. We identify 56 genes, which are differentially expressed between the two groups. In this list of genes, we confirm an enrichment of genes related to the TNFβ-signaling pathway, extracellular matrix organization, vascular development, and endothelium damage, which also have been identified in previous studies. However, the genes with the greatest difference in expression between the two groups are CNTN3 and MYH1. Both genes encode proteins, which are predicted to have an effect on the contractile activity of myocardial cells, which in turn may have an effect on valvular performance and hemodynamics across the mitral valve. This may result in shear forces with impact on MMVD progression.

AB - We here report the results of a mitral valve transcriptome study designed to identify genes and molecular pathways involved in development of congestive heart failure (CHF) following myxomatous mitral valve disease (MMVD) in dogs. The study is focused on a cohort of elderly age-matched dogs (n = 34, age ~ 10 years) from a single breed—Cavalier King Charles Spaniels (CKCS)—with a high incidence of MMVD. The cohort comprises 19 dogs (10♀, 9♂) without MMVD-associated CHF, and 15 dogs (6♀, 9♂) with CHF caused by MMVD; i.e., we compare gene expression in breed and age-matched groups of dogs, which only differ with respect to CHF status. We identify 56 genes, which are differentially expressed between the two groups. In this list of genes, we confirm an enrichment of genes related to the TNFβ-signaling pathway, extracellular matrix organization, vascular development, and endothelium damage, which also have been identified in previous studies. However, the genes with the greatest difference in expression between the two groups are CNTN3 and MYH1. Both genes encode proteins, which are predicted to have an effect on the contractile activity of myocardial cells, which in turn may have an effect on valvular performance and hemodynamics across the mitral valve. This may result in shear forces with impact on MMVD progression.

U2 - 10.1007/s00335-023-10024-1

DO - 10.1007/s00335-023-10024-1

M3 - Journal article

C2 - 37938355

AN - SCOPUS:85176101274

VL - 35

SP - 77

EP - 89

JO - Mammalian Genome

JF - Mammalian Genome

SN - 0938-8990

IS - 1

ER -

ID: 385695764