Bacteriophage Moonlighting Proteins in the Control of Bacterial Pathogenicity
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
This chapter describes the dual role of bacteria-encoded proteins along with their impact on the bacteriophage biology and the repercussion in bacterial pathogenicity. The use of bacteriophage-encoded proteins as de-repressor proteins is an elegant strategy that allows the Staphylococcus aureus pathogenicity islands (SaPI) to be induced only when the helper phage has entered the lytic cycle. The chapter examines the dual role of various well-known and well-characterized bacteriophage moonlighting proteins and their impact on bacterial pathogenicity. The first example of moonlighting proteins studied was the homing endonuclease T4 I-TevI encoded by the T4 bacteriophage. This homing endonuclease, in addition to its main cleavage activity, has a role as a transcriptional regulator controlling its own transfer. Understanding the biology of bacteriophages is of great importance due to their crucial role in bacterial pathogenicity, as well as for the study of the different proteins and functions that they have for their own biology.
Original language | English |
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Title of host publication | Moonlighting Proteins : Novel Virulence Factors in Bacterial Infections |
Number of pages | 26 |
Publisher | Wiley-Blackwell |
Publication date | 3 Oct 2016 |
Pages | 387-412 |
ISBN (Print) | 9781118951118 |
ISBN (Electronic) | 9781118951149 |
DOIs | |
Publication status | Published - 3 Oct 2016 |
Bibliographical note
Publisher Copyright:
© 2017 John Wiley & Sons, Inc.
- Bacterial pathogenicity, Bacteriophage moonlighting proteins, Bacteriophage P4 functions, Homing endonuclease T4 I-TevI, Staphylococcus aureus pathogenicity islands, T7 DNA polymerase, Transcriptional autorepressor
Research areas
ID: 373882992