A protein-centric view of in vitro biological model systems for schizophrenia

Research output: Contribution to journal › Review › Research › peer-review

Standard

A protein-centric view of in vitro biological model systems for schizophrenia. / Chandrasekaran, Abinaya; Jensen, Pia; Mohamed, Fadumo A; Lancaster, Madeline; Benros, Michael E; Larsen, Martin R; Freude, Kristine K.

In: Stem Cells, Vol. 39, No. 12, 2021, p. 1569-1578.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Chandrasekaran, A, Jensen, P, Mohamed, FA, Lancaster, M, Benros, ME, Larsen, MR & Freude, KK 2021, 'A protein-centric view of in vitro biological model systems for schizophrenia', Stem Cells, vol. 39, no. 12, pp. 1569-1578. https://doi.org/10.1002/stem.3447

APA

Chandrasekaran, A., Jensen, P., Mohamed, F. A., Lancaster, M., Benros, M. E., Larsen, M. R., & Freude, K. K. (2021). A protein-centric view of in vitro biological model systems for schizophrenia. Stem Cells, 39(12), 1569-1578. https://doi.org/10.1002/stem.3447

Vancouver

Chandrasekaran A, Jensen P, Mohamed FA, Lancaster M, Benros ME, Larsen MR et al. A protein-centric view of in vitro biological model systems for schizophrenia. Stem Cells. 2021;39(12):1569-1578. https://doi.org/10.1002/stem.3447

Author

Chandrasekaran, Abinaya ; Jensen, Pia ; Mohamed, Fadumo A ; Lancaster, Madeline ; Benros, Michael E ; Larsen, Martin R ; Freude, Kristine K. / A protein-centric view of in vitro biological model systems for schizophrenia. In: Stem Cells. 2021 ; Vol. 39, No. 12. pp. 1569-1578.

Bibtex

@article{f338b23c4b98457b9b2c63d8580809a9,
title = "A protein-centric view of in vitro biological model systems for schizophrenia",
abstract = "Schizophrenia (SCZ) is a severe brain disorder, characterized by psychotic, negative, and cognitive symptoms, affecting 1% of the population worldwide. The precise etiology of SCZ is still unknown; however, SCZ has a high heritability, and is associated with genetic, environmental, and social risk factors. Even though the genetic contribution is indisputable, the discrepancies between transcriptomics and proteomics in brain tissues are consistently challenging the field to decipher the disease pathology. Here we provide an overview of the state of the art of neuronal two-dimensional and three-dimensional model systems that can be combined with proteomics analyses to decipher specific brain pathology and detection of alternative entry points for drug development.",
author = "Abinaya Chandrasekaran and Pia Jensen and Mohamed, {Fadumo A} and Madeline Lancaster and Benros, {Michael E} and Larsen, {Martin R} and Freude, {Kristine K}",
note = "{\textcopyright}2021 The Authors. Stem Cells published by Wiley Periodicals LLC on behalf of AlphaMed Press 2021.",
year = "2021",
doi = "10.1002/stem.3447",
language = "English",
volume = "39",
pages = "1569--1578",
journal = "Stem Cells",
issn = "1066-5099",
publisher = "AlphaMed Press, Inc.",
number = "12",

}

RIS

TY - JOUR

T1 - A protein-centric view of in vitro biological model systems for schizophrenia

AU - Chandrasekaran, Abinaya

AU - Jensen, Pia

AU - Mohamed, Fadumo A

AU - Lancaster, Madeline

AU - Benros, Michael E

AU - Larsen, Martin R

AU - Freude, Kristine K

N1 - ©2021 The Authors. Stem Cells published by Wiley Periodicals LLC on behalf of AlphaMed Press 2021.

PY - 2021

Y1 - 2021

N2 - Schizophrenia (SCZ) is a severe brain disorder, characterized by psychotic, negative, and cognitive symptoms, affecting 1% of the population worldwide. The precise etiology of SCZ is still unknown; however, SCZ has a high heritability, and is associated with genetic, environmental, and social risk factors. Even though the genetic contribution is indisputable, the discrepancies between transcriptomics and proteomics in brain tissues are consistently challenging the field to decipher the disease pathology. Here we provide an overview of the state of the art of neuronal two-dimensional and three-dimensional model systems that can be combined with proteomics analyses to decipher specific brain pathology and detection of alternative entry points for drug development.

AB - Schizophrenia (SCZ) is a severe brain disorder, characterized by psychotic, negative, and cognitive symptoms, affecting 1% of the population worldwide. The precise etiology of SCZ is still unknown; however, SCZ has a high heritability, and is associated with genetic, environmental, and social risk factors. Even though the genetic contribution is indisputable, the discrepancies between transcriptomics and proteomics in brain tissues are consistently challenging the field to decipher the disease pathology. Here we provide an overview of the state of the art of neuronal two-dimensional and three-dimensional model systems that can be combined with proteomics analyses to decipher specific brain pathology and detection of alternative entry points for drug development.

U2 - 10.1002/stem.3447

DO - 10.1002/stem.3447

M3 - Review

C2 - 34431581

VL - 39

SP - 1569

EP - 1578

JO - Stem Cells

JF - Stem Cells

SN - 1066-5099

IS - 12

ER -

ID: 279189471